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Chapter 9 - Acute lung injury

Published online by Cambridge University Press:  05 June 2014

By
William A.H. Wallace ,
A. John Simpson  and
Nik Hirani
Edited by
Philip Hasleton  and
Douglas B. Flieder
Philip Hasleton
Affiliation:
University of Manchester
Douglas B. Flieder
Affiliation:
Fox Chase Cancer Center, Philadelphia
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Type
Chapter
Information
Spencer's Pathology of the Lung , pp. 342 - 365
Publisher: Cambridge University Press
Print publication year: 2000

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References

Ashbaugh, DG, Bigelow, DB, Petty, TL, Levine, BE.Acute respiratory distress in adults. Lancet 1967;2(7511):319–23.CrossRefGoogle ScholarPubMed
Bernard, GR, Artigas, A, Brigham, KL, et al. Report of the American-European consensus conference on ARDS: definitions, mechanisms, relevant outcomes and clinical trial coordination. Intensive Care Med 1994;20:225–32.CrossRefGoogle ScholarPubMed
Ferguson, ND, Frutos-Vivar, F, Esteban, A, et al. Acute respiratory distress syndrome: underrecognition by clinicians and diagnostic accuracy of three clinical definitions. Crit Care Med 2005;33:2228–34.CrossRefGoogle ScholarPubMed
Phua, J, Stewart, TE, Ferguson, ND.Acute respiratory distress syndrome 40 years later: time to revisit its definition. Crit Care Med 2008;36:2912–21.CrossRefGoogle ScholarPubMed
Stevens, JH, Raffin, TA.Acute respiratory distress syndrome 1. Aetiology and mechanisms. Postgrad Med J 1984;60:505–13.CrossRefGoogle Scholar
Ware, LB, Matthay, MA.The acute respiratory distress syndrome. N Engl J Med 2000;342:1334–49.CrossRefGoogle ScholarPubMed
Hui, DS.Review of clinical symptoms and spectrum in humans with influenza A/H5N1 infection. Respirology 2008;13(Suppl 1):S10–13.CrossRefGoogle ScholarPubMed
Chowell, G, Bertozzi, SM, Colchero, MA, et al. Severe respiratory disease concurrent with the circulation of H1N1 influenza. N Engl J Med 2009;361:674–9.CrossRefGoogle ScholarPubMed
Centers for Disease Control and Prevention (CDC). Intensive-care patients with severe novel influenza A (H1N1) virus infection – Michigan, June 2009. MMWR Morb Mortal Wkly Rep 2009;58:749–52.Google Scholar
Kumar, A, Zarychanski, R, Pinto, R, et al. Canadian Critical Care Trials Group H1N1 Collaborative. Critically ill patients with 2009 influenza A (H1N1) infection in Canada. JAMA 2009;302:1872–9.CrossRefGoogle Scholar
Davies, A, Jones, D, Bailey, M, et al. Extracorporeal membrane oxygenation for 2009 influenza A (H1N1) acute respiratory distress syndrome. JAMA 2009;302:1888–95.Google ScholarPubMed
Callister, ME, Evans, TW.Pulmonary versus extrapulmonary acute respiratory distress syndrome: different diseases or just a useful concept?Curr Opin Crit Care 2002;8:21–5.CrossRefGoogle ScholarPubMed
Rocco, PR, Pelosi, P.Pulmonary and extrapulmonary acute respiratory distress syndrome: myth or reality?Curr Opin Crit Care 2008;14:50–5.CrossRefGoogle ScholarPubMed
Dellinger, RP, Levy, MM, Carlet, JM, et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008Crit Care Med 2008;36:296–327.CrossRefGoogle ScholarPubMed
Villar, J, Flores, C, Perez-Mendez, L, Blanco, J, Muros, M.Genetic determinants of survival in sepsis and acute lung injury. Minerva Anestesiol 2008;74:341–5.Google ScholarPubMed
Rahim, NG, Harismendy, O, Topol, EJ, Frazer, KA.Genetic determinants of phenotypic diversity in humans. Genome Biol 2008;9:215.CrossRefGoogle ScholarPubMed
Cobb, JP, O'Keefe, GE.Injury research in the genomic era. Lancet 2004;363: 2076–83.CrossRefGoogle ScholarPubMed
Gao, L, Barnes, KC.Recent advances in genetic predisposition to clinical acute lung injury. Am J Physiol Lung Cell Mol Physiol 2009;296:L713–25.CrossRefGoogle ScholarPubMed
Tejera, P, Wang, Z, Zhai, R, et al. Genetic polymorphisms of peptidase inhibitor 3 (elafin) are associated with ARDS. Am J Respir Cell Mol Biol 2009;41:696–704.CrossRefGoogle Scholar
Meyer, NJ, Garcia, JG N.Wading into the genomic pool to unravel acute lung injury genetics. Proc Am Thorac Soc 2007;4:69–76.CrossRefGoogle ScholarPubMed
Kamp, R, Sun, X, Garcia, JG J N.Making genomics functional. Deciphering the genetics of acute lung injury. Proc Am Thorac Soc 2008;5:348–53.CrossRefGoogle ScholarPubMed
Song, Z, Tong, C, Sun, Z, et al. Genetic variants in the TIRAP gene are associated with increased risk of sepsis-associated acute lung injury. BMC Med Genet 2010;11:168.CrossRefGoogle ScholarPubMed
Zhou, T, Garcia, JG, Zhang, W.Integrating microRNAs into a system biology approach to acute lung injury. Transl Res 2011;157:180–90.CrossRefGoogle ScholarPubMed
Rubenfeld, GD, Caldwell, E, Peabody, E, et al. Incidence and outcome of acute lung injury. N Engl J Med 2005;353:1685–93.CrossRefGoogle ScholarPubMed
Brun-Buisson, C, Minelli, C, Bertolini, G, et al. Epidemiology and outcome of acute lung injury in European intensive care units. Results from the ALIVE study. Intensive Care Med 2004;30:51–61.CrossRefGoogle ScholarPubMed
Hughes, M, Mackirdy, FN, Ross, J, Norrie, J, Grant, IS.Adult respiratory distress syndrome: an audit of incidence and outcome in Scottish intensive care units. Anaesthesia 2003;58:838–45.CrossRefGoogle ScholarPubMed
Wind, J, Versteegt, J, Twisk, J, et al. Epidemiology of acute lung injury and acute respiratory distress syndrome in the Netherlands: a survey. Respir Med 2007;101:2091–8.CrossRefGoogle ScholarPubMed
Rubenfeld, GD.Epidemiology of acute lung injury. Crit Care Med 2003; 31(4 Suppl): S276–84.CrossRefGoogle ScholarPubMed
Frutos-Vivar, F, Nin, N, Esteban, A.Epidemiology of acute lung injury and acute respiratory distress syndrome. Curr Opin Crit Care 2004;10:1–6.CrossRefGoogle ScholarPubMed
MacCallum, NS, Evans, TW.Epidemiology of acute lung injury. Curr Opin Crit Care 2005;11:43–9.CrossRefGoogle ScholarPubMed
Erickson, SE, Shlipak, MG, Martin, GS, et al. National Institutes of Heart, Lung, and Blood Acute Respiratory Distress Syndrome Network. Racial and ethnic disparities in mortality from acute lung injury. Crit Care Med 2009;37:1–6.CrossRefGoogle ScholarPubMed
Zambon, M, Vincent, JL.Mortality rates for patients with acute lung injury/ARDS have decreased over time. Chest 2008;133:1120–7.CrossRefGoogle ScholarPubMed
Cheung, AM, Tansey, CM, Tomlinson, G, et al. Two-year outcomes, health care use, and costs of survivors of acute respiratory distress syndrome. Am J Respir Crit Care Med 2006;174:538–44.CrossRefGoogle ScholarPubMed
Angus, DC, Clermont, G, Linde-Zwirble, WT, et al. Healthcare costs and long-term outcomes after acute respiratory distress syndrome: a phase III trial of inhaled nitric oxide. Crit Care Med 2006;34:2883–90.CrossRefGoogle ScholarPubMed
Heyland, DK, Groll, D, Caeser, M.Survivors of acute respiratory distress syndrome: relationship between pulmonary dysfunction and long-term health-related quality of life. Crit Care Med 2005;33:1549–56.CrossRefGoogle ScholarPubMed
Rubenfeld, GD, Herridge, MS.Epidemiology and outcomes of acute lung injury. Chest 2007;131:554–62.CrossRefGoogle ScholarPubMed
Terminella, L, Sharma, G.Diagnostic studies in patients with acute respiratory distress syndrome. Semin Thorac Cardiovasc Surg 2006;18:2–7.CrossRefGoogle ScholarPubMed
Rubenfeld, GD, Caldwell, E, Granton, J, Hudson, LD, Matthay, MA.Interobserver variability in applying a radiographic definition for ARDS. Chest 1999;116:1347–53.CrossRefGoogle ScholarPubMed
Meade, MO, Cook, RJ, Guyatt, GH, et al. Interobserver variation in interpreting chest radiographs for the diagnosis of adult respiratory distress syndrome. Am J Respir Crit Care Med 2000;161:85–90.CrossRefGoogle Scholar
Maunder, RJ, Shuman, WP, McHugh, JW, Marglin, SI, Butler, J.Preservation of normal lung regions in the adult respiratory distess syndrome. Analysis by computed tomography. JAMA 1986;255:2463–5.CrossRefGoogle ScholarPubMed
Rouby, JJ, Puybasset, L, Nieszkowska, A, Lu, Q.Acute respiratory distress syndrome: lessons from computed tomography of the whole lung. Crit Care Med 2003;31(4 Suppl): S285–95.CrossRefGoogle ScholarPubMed
Gattinoni, L, Caironi, P, Cressoni, M, et al. Lung recruitment in patients with acute respiratory distress syndrome. N Engl J Med 2006;354:1775–86.CrossRefGoogle ScholarPubMed
Bouros, D, Nicholson, AC, Polychronopoulos, V, du Bois, RM.Acute interstitial pneumonia. Eur Respir J 2000;15:412–18.CrossRefGoogle ScholarPubMed
Tomashefski, JF.Pulmonary pathology of acute respiratory distress syndrome. Clin Chest Med 2000;3:435–66.CrossRefGoogle Scholar
Castro, CY.ARDS and diffuse alveolar damage: a pathologist's perspective. Semin Thorac Cardiovasc Surg 2006;18:13–19.CrossRefGoogle ScholarPubMed
Katzenstein, AA.Acute lung injury patterns: diffuse alveolar damage and bronchiolitis obliterans organising pneumonia. In Surgical Pathology of Non-neoplastic Lung Disease, 4th ed. Saunders Elsevier, 2006. pp. 17–50.Google Scholar
Travis, WD, Colby, TV, Koss, MN, et al., eds. Idiopathic interstitial pneumonia and other diffuse parenchymal lung diseases. In Non-neoplastic Disorders of the Lower Respiratory Tract. Washington DC: AFIP, 2002. pp. 49–233.Google Scholar
Lachmann, B.Open lung biopsy in ARDS. Minerva Anesthesiol 2002;68:637–42.Google ScholarPubMed
Malhotra, A, Patel, S.Lung biopsy in ARDS: is it worth the risk?Crit Care 2006;10:160CrossRefGoogle ScholarPubMed
Donati, SY, Papazian, L.Role of open lung biopsy in acute respiratory distress syndrome. Curr Opin Crit Care 2008;14:75–9.CrossRefGoogle ScholarPubMed
Riede, UN, Joachim, H, Hassenstein, J, et al. The pulmonary air-blood barrier of human shock lungs (a clinical, ultrastructural and morphometric study). Pathol Res Pract 1978;162:41–72.CrossRefGoogle Scholar
Schnells, G, Voigt, WH, Redl, H, Schlag, G, Glatzel, A.Electron microscopic investigation of lung biopsies in patients with posttraumatic respiratory insufficiency. Acta Chir Scand 1980;499(Suppl):9–20.Google Scholar
Menezes, SL, Bozza, PT, Neto, HC, et al. Pulmonary and extrapulmonary acute lung injury: inflammatory and ultrastructural analyses. J Appl Physiol 2005;98:1777–83.CrossRefGoogle ScholarPubMed
Matsubara, O, Tamura, A, Ohdama, S, Mark, EJ.Alveolar basement membrane breaks down in DAD: an immunohistochemical study. Pathol Int 1995;45:473–82.CrossRefGoogle ScholarPubMed
Pache, J, Christakos, PG, Gannon, DE, et al. Myofibroblasts in diffuse alveolar damage of the lung. Mod Pathol 1998;11:1064–70.Google ScholarPubMed
Akira, M.Computed tomography and pathological findings in fulminant forms of idiopathic interstitial pneumonia. Thorac Imag 1999;14:76–84.CrossRefGoogle ScholarPubMed
Beasley, MB, Franks, TJ, Galvin, JR, Gochuico, B, Travis, WD.Acute fibrinous and organising pneumonia: a histological pattern of lung injury and possible variant of diffuse alveolar damage. Arch Pathol Lab Med 2002;126:1064–70.Google Scholar
Esteban, A, Fernández-Segoviano, P, Frutos-Vivar, F, et al. Comparison of clinical criteria for the acute respiratory distress syndrome with autopsy findings. Ann Intern Med 2004;141:440–5.CrossRefGoogle ScholarPubMed
Pinheiro, BV, Muraoka, FS, Assis, RVC, et al. Accuracy of clinical diagnosis of acute respiratory distress syndrome in comparison with autopsy findings. J Bras Pneumol 2007;33:423–8.CrossRefGoogle ScholarPubMed
de Hemptinne, , Remmelink, M, Brimioulle, S, Salmon, I, Vincent, JL.Acute respiratory distress syndrome: a clinicopathological confrontation. Chest 2009;135:944–9.CrossRefGoogle ScholarPubMed
Meduri, GU, Chastre, J.The standardization of bronchoscopic techniques for ventilator-associated pneumonia. Chest 1992;102:557S–64S.CrossRefGoogle ScholarPubMed
Baselski, VS, Wunderink, RG.Bronchoscopic diagnosis of pneumonia. Clin Microbiol Rev 1994;7:533–58.CrossRefGoogle ScholarPubMed
Weiland, JE, Davis, WB, Holter, JF, et al. Lung neutrophils in the adult respiratory distress syndrome. Clinical and pathophysiologic significance. Am Rev Respir Dis 1986;133:218–25.Google ScholarPubMed
Chastre, J, Fagon, JY.Ventilator-associated pneumonia. Am J Respir Crit Care Med 2002;165:867–903.CrossRefGoogle ScholarPubMed
Cook, D, Mandell, L.Endotracheal aspiration in the diagnosis of ventilator-associated pneumonia. Chest 2000;117(4 Suppl 2):195S–7S.CrossRefGoogle Scholar
El-Ebiary, M, Torres, A, González, J, et al. Quantitative cultures of endotracheal aspirates for the diagnosis of ventilator-associated pneumonia. Am Rev Respir Dis 1993;148(6 Pt 1):1552–7.CrossRefGoogle Scholar
Jourdain, B, Novara, A, Joly-Guillou, ML, et al. Role of quantitative cultures of endotracheal aspirates in the diagnosis of nosocomial pneumonia. Am J Respir Crit Care Med 1995;152:241–6.CrossRefGoogle Scholar
Morris, AC, Kefala, K, Simpson, AJ, et al. Evaluation of the effect of diagnostic methodology on the reported incidence of ventilator-associated pneumonia. Thorax 2009;64:512–22.CrossRefGoogle ScholarPubMed
Baughman, RP.Protected-specimen brush technique in the diagnosis of ventilator-associated pneumonia. Chest 2000;117(4 Suppl 2):203S–6S.CrossRefGoogle Scholar
Perkins, GD, Chatterjie, S, McAuley, DF, Gao, F, Thickett, DR.Role of non-bronchoscopic lavage for investigating alveolar inflammation and permeability in acute respiratory distress syndrome. Crit Care Med 2006;34:57–64.CrossRefGoogle Scholar
Papin, TA, Grum, CM, Weg, JG.Transbronchial biopsy during mechanical ventilation. Chest 1986;89:168–70.CrossRefGoogle ScholarPubMed
Pincus, PS, Kallenbach, JM, Hurwitz, MD, et al. Transbronchial biopsy during mechanical ventilation. Crit Care Med 1987;15:1136–9.CrossRefGoogle ScholarPubMed
O'Brien, J, Ettinger, N, Shevlin, D, Kollef, MH.Safety and yield of transbronchial biopsy in mechanically ventilated patients. Crit Care Med 1997;25:440–6.CrossRefGoogle ScholarPubMed
Bulpa, PA, Dive, AM, Mertens, L, et al. Combined bronchoalveolar lavage and transbronchial lung biopsy: safety and yield in ventilated patients. Eur Respir J 2003;21:489–94.CrossRefGoogle ScholarPubMed
Rao, VK, Ritter, J, Kollef, MH.Utility of transbronchial biopsy in patients with acute respiratory failure: a postmortem study. Chest 1998;114:549–55.CrossRefGoogle ScholarPubMed
Martin, C, Papazian, L, Payan, MJ, Saux, P, Gouin, F.Pulmonary fibrosis correlates with outcome in adult respiratory distress syndrome. A study in mechanically ventilated patients. Chest 1995;107:196–200.CrossRefGoogle ScholarPubMed
Patel, SR, Karmpaliotis, D, Ayas, NT, Mark, EJ, Wain, J, Thompson, BT, Malhotra, A.The role of open-lung biopsy in ARDS. Chest 2004;125:197–202.CrossRefGoogle ScholarPubMed
Kao, KC, Tsai, YH, Wu, YK, et al. Open lung biopsy in early-stage acute respiratory distress syndrome. Crit Care 2006;10:R106.CrossRefGoogle ScholarPubMed
Charbonney, E, Robert, J, Pache, JC, Chevrolet, JC, Eggimann, P.Impact of bedside open lung biopsies on the management of mechanically ventilated immunocompromised patients with acute respiratory distress syndrome of unknown etiology. J Crit Care 2009;24:122–8.CrossRefGoogle ScholarPubMed
Papazian, L, Thomas, P, Bregeon, F, et al. Open-lung biopsy in patients with acute respiratory distress syndrome. Anesthesiology 1998;88:935–44.CrossRefGoogle ScholarPubMed
Papazian, L, Doddoli, C, Chetaille, B, et al. A contributive result of open-lung biopsy improves survival in acute respiratory distress syndrome patients. Crit Care Med 2007;35:755–62.CrossRefGoogle ScholarPubMed
Cho, MH, Malhotra, A, Donahue, DM, et al. Mechanical ventilation and air leaks after lung biopsy for acute respiratory distress syndrome. Ann Thorac Surg 2006;82:261–6.CrossRefGoogle ScholarPubMed
Baumann, HJ, Kluge, S, Balke, L, et al. Yield and safety of bedside open lung biopsy in mechanically ventilated patients with acute lung injury or acute respiratory distress syndrome. Surgery 2008;143:426–33.CrossRefGoogle ScholarPubMed
Flabouris, A, Myburgh, J.The utility of open lung biopsy in patients requiring mechanical ventilation. Chest 1999;115:811–17.CrossRefGoogle ScholarPubMed
Soh, LH, Chian, CF, Su, WL, et al. Role of open lung biopsy in patients with diffuse lung infiltrates and acute respiratory failure. J Formos Med Assoc 2005;104:17–21.Google ScholarPubMed
Canzian, M, Soeiro Ade, M, Taga, MF, Barbas, CS, Capelozzi, VL.Correlation between surgical lung biopsy and autopsy findings and clinical data in patients with diffuse pulmonary infiltrates and acute respiratory failure. Clinics (Sao Paulo) 2006;61:425–32.CrossRefGoogle ScholarPubMed
Barbas, CS, Capelozzi, VL, Hoelz, C, et al. Impact of open lung biopsy on refractory acute respiratory failure. J Bras Pneumol 2006;32:418–23.CrossRefGoogle ScholarPubMed
Arabi, Y, Ahmed, R, Ahmed, Q, Rahman, MU, Yamani, N.Risks and benefits of open-lung biopsy in the mechanically ventilated critically ill population: a cohort study and literature review. Med Sci Monit 2007;13:CR365–71.Google ScholarPubMed
Parambil, JG, Myers, JL, Aubry, MC, Ryu, JH.Causes and prognosis of diffuse alveolar damage diagnosed on surgical lung biopsy. Chest 2007;132:50–7.CrossRefGoogle ScholarPubMed
Matthay, MA, Iddel, S.Update on acute lung injury and critical care medicine 2009. Am J Respir Crit Care Med 2010; 181:1027–32.CrossRefGoogle Scholar
Ware, LB.Pathophysiology of acute lung injury and the adult respiratory distress syndrome. Semin Respir Crit Care Med 2006;27:337–49.CrossRefGoogle Scholar
Warshawski, FJ, Sibbald, W, Martin, TR, Driedger, AA, Cheung, H.Abnormal neutrophil-pulmonary interaction in the adult respiratory distress syndrome: qualitative and quantitative of pulmonary-neutrophil kinetics in humans with in vivo indium-111 neutrophil scintigraphy. Am Rev Resp Dis 1986;133:792–804.Google Scholar
Pratt, PC, Vollmer, RT, Shelburne, JD, Crapo, JD.Pulmonary morphology in a multihospital collaborative extracorporeal membrane oxygenation project. Am J Pathol 1979;95:191–214.Google Scholar
Bachofen, M, Weibel, ER.Structural alterations of lung parenchyma in the adult respiratory distress syndrome. Clin Chest Med 1982;3:35–56.Google ScholarPubMed
Parsons, PE, Fowler, AA, Hyers, T, Henson, PM.Chemotactic activity in bronchoalveolar lavage fluid from patients with the adult respiratory distress syndrome. Am Rev Resp Dis 1985;132:490–3.Google ScholarPubMed
Donnelly, SC, Streiter, RM, Kunkel, SL, et al. Interleukin-8 and development of adult respiratory distress syndrome in at-risk patient groups. Lancet 1993;341:643–7.CrossRefGoogle ScholarPubMed
Laufe, MD, Simon, RH, Flint, A, Keller, JB.Adult respiratory distress syndrome in neutropenic patients. Am J Med 1986;80:1022–6.CrossRefGoogle ScholarPubMed
Puneet, P, Moochhala, S, Bhatia, M.Chemokines in acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol 2005;288:L3–15.CrossRefGoogle ScholarPubMed
Shimabukuro, DW, Sawa, T, Gropper, MA.Injury and repair in lung and airways. Crit Care Med 2003;31(Suppl):S524–31.CrossRefGoogle ScholarPubMed
Doerschuk, CM.Mechanisms of leukocyte sequestration in inflamed lungs. Microcirculation 2001;8:71–88.CrossRefGoogle ScholarPubMed
Worthen, GS, Schwab, B, Elson, EL, Donney, GP.Mechanics of stimulated neutrophils: cell stiffening induces retention in capillaries. Science 1989;245:183–5.CrossRefGoogle ScholarPubMed
Lavkan, AH, Astiz, ME, Rackow, EC.Effects of proinflammatory cytokines and bacterial toxins on neutrophil rheological properties. Crit Care Med 1998;26:1677–82.CrossRefGoogle Scholar
Zimmerman, GA, Albertine, KH, Carveth, HJ, et al. Endothelial activation in ARDS. Chest 1999;116:18S–24SCrossRefGoogle ScholarPubMed
Bhatia, M, Moochhala, S.Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome. J Pathol 2004;202:145–56.CrossRefGoogle ScholarPubMed
Nagase, T, Ohga, E, Sudo, E, et al. Intercellular adhesion molecule-1 mediates acid aspiration-induced lung injury. Am J Respir Crit Care Med 1996;154:504–10.CrossRefGoogle ScholarPubMed
Folkesson, HG, Matthay, MA.Inhibition of CD18 or CD11b attenuates acute lung injury after acid instillation in rabbits. J Appl Physiol 1997;82:1743–50.CrossRefGoogle ScholarPubMed
Finigan, JH, Faress, JA, Wilkinson, E, et al. Neuregulin-1-human epidermal receptor-2 signaling is a central regulator of pulmonary epithelial permeability and acute lung injury. J Biol Chem 2011;286:10660–70.CrossRefGoogle ScholarPubMed
Moraes, TJ, Zurawska, JH, Downey, GP.Neutrophil granule contents in the pathogenesis of lung injury. Curr Opin Haematol 2006;13:21–7.CrossRefGoogle ScholarPubMed
Donnelly, SC, MacGregor, I, Zamani, , et al. Plasma elastase levels and the development of the adult respiratory syndrome. Am J Respir Crit Care Med 1995;151:1428–33.CrossRefGoogle Scholar
Gando, S, Kameue, T, Nanzaki, S, Hayakawa, T, Nakanishi, Y.Increased neutrophil elastase, persistent intravascular coagulation and decreased fibrinolytic activity in patients with posttraumatic acute respiratory distress syndrome. J Trauma 1997;42:1068–72.CrossRefGoogle ScholarPubMed
Christner, P, Fein, AM, Goldberg, S, et al. Collagenase in the lower respiratory tract of patients with adult respiratory distress syndrome. Am Rev Resp Dis 1985;131:690–5.Google ScholarPubMed
Delclaux, C, d'Ortho, MP, Delacourt, C, et al. Gelatinases in epithelial lining fluid of patients with adult respiratory distress syndrome. Am J Physiol 1997;272:L442–51.Google ScholarPubMed
Haslett, C.Granulocyte apoptosis and its role in the resolution and control of lung inflammation. Am J Respir Crit Care Med 1999;160:S5–11.CrossRefGoogle ScholarPubMed
Matute-Bello, G, Liles, WC, Radella, F, et al. Neutrophil apoptosis in the acute respiratory distress syndrome. Am J Respir Crit Care Med 1997;156:1969–77.CrossRefGoogle ScholarPubMed
Hussain, N, Wu, F, Zhu, L, Thrall, RS, Kresch, MJ.Neutrophil apoptosis during the development and resolution of oleic acid-induced acute lung injury in the rat. Am J Respir Cell Mol Biol 1998;19:867–74.CrossRefGoogle ScholarPubMed
Carter, AB, Monick, MM, Hunninghake, GW.Lipopolysaccharide-induced NF-κB activation and cytokine release in human alveolar macrophages is PKC-independent and TK- and PC-dependent. Am J Respir Cell Mol Biol 1998;18:384–91.CrossRefGoogle Scholar
Lai, KN, Leung, JCK, Metz, CN, et al. Role for macrophage migration inhibitory factor in acute respiratory distress syndrome. J Pathol 2003;199:496–508.CrossRefGoogle ScholarPubMed
Steinberg, KP, Milberg, JA, Martin, TR, et al. Evolution of bronchoalveolar cell populations in the adult respiratory distress syndrome. Am J Respir Crit Care Med 1994;150:113–22.CrossRefGoogle ScholarPubMed
Rosseau, S, Hammerl, P, Maus, U, et al. Phenotypic characterisation of alveolar monocyte recruitment in acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol 2000;279:L25–35.CrossRefGoogle Scholar
Sittipunt, C, Steinberg, KP, Ruzinski, JT, et al. Nitric oxide and nitrotyrosine in the lungs of patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 2001;163:503–50.CrossRefGoogle ScholarPubMed
Frank, JA, Wray, CM, McAuley, DF, Schwendener, R, Matthay, MA.Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol 2006;291:L1191–8.CrossRefGoogle ScholarPubMed
Looney, MR, Nguyen, JX, Hu, Y,et al. Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury. J Clin Invest 2009;119:3450–61.Google Scholar
Scheiermann, C, Kunisaki, Y, Jang, JE, Frenette, PS.Neutrophil microdomains: linking heterocellular interactions with vascular injury. Curr Opin Hematol 2010;17:25–30.CrossRefGoogle ScholarPubMed
Maniatis, NA, Orfanos, SE.The endothelium in acute lung injury/acute respiratory distress syndrome. Curr Opin Crit Care 2008;14:22–30.CrossRefGoogle ScholarPubMed
Orfanos, SE, Mavrommati, I, Korovesi, I, Roussos, C.Pulmonary endothelium in acute lung injury: from basic science to the critically ill. Intensive Care Med 2004;30:1702–14.CrossRefGoogle ScholarPubMed
Ware, LB, Matthay, MA.Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome. Am J Respir Crit Care Med 2001;163:1376–83.CrossRefGoogle ScholarPubMed
Pittet, JF, Morel, DR, Hemsen, A, et al. Elevated plasma endothelin-1 concentrations are associated with the severity of illness in patients with sepsis. Ann Surg 1991;213:261–4.CrossRefGoogle ScholarPubMed
Langleben, D, Demarchie, M, Laporta, D, et al. Endothelin-1 in acute lung injury and the adult respiratory distress syndrome. Am Rev Respir Dis 1993;148:1646–50.CrossRefGoogle ScholarPubMed
Ware, LB, Conner, ER, Matthay, MA.von Willbrand factor antigen is an independent marker of poor outcome in patients with early acute lung injury. Crit Care Med 2001;29:2325–31.CrossRefGoogle Scholar
Ware, LB, Eisner, MD, Thompson, BT, Parsons, PE, Matthay, MA.Significance of von Willebrand factor in septic and non-septic patients with acute lung injury. Am J Respir Crit Care Med 2004;170:766–72.CrossRefGoogle Scholar
Dhainaut, JF, Charpetier, J, Chiche, JD.Transforming growth factor-beta: a mediator of cell regulation in acute respiratory distress syndrome. Crit Care Med 2003:31(4 Suppl);S258–64.CrossRefGoogle ScholarPubMed
Alberine, KH.Ultrastructural abnormalities in increased-permeability pulmonary oedema. Clin Chest Med 1985;6:345–66.Google Scholar
Hurley, JV.Types of pulmonary microvascular injury. Ann NY Acad Sci 1982;384:269–86.CrossRefGoogle ScholarPubMed
Wiener-Kronish, JP, Albertine, KH, Matthay, MA.Differential responses of the endothelial and epithelial barriers of the lung in sheep to Escherichia coli endotoxin. J Clin Invest 1991;88:864–75.CrossRefGoogle ScholarPubMed
Dudek, SM, Garcia, JG.Cytoskeletal regulation of pulmonary vascular permeability. J Appl Physiol 2001;91:1487–500.CrossRefGoogle ScholarPubMed
Rossi, JL, Velentza, AV, Steinhorn, DM, Watterson, DM, Wainwright, MS.MLCK210 gene knockout or kinase inhibition preserves lung function following endotoxin-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol 2007;292:L1327–34.CrossRefGoogle ScholarPubMed
Alvarez, DF, King, JA, Weber, D, et al. Transient receptor potential vanilloid 4-mediated disruption of the alveolar septal barrier: a novel mechanism of acute lung injury, Circ Res 2006;99:988–95.CrossRefGoogle ScholarPubMed
Parthasarathi, K, Ichimura, H, Monma, E, et al. Connexin 43 mediates spread of Ca2+ – dependent pro-inflammatory responses in lung capillaries. J Clin Invest 2006;116:2193–200.CrossRefGoogle Scholar
Angelini, DJ, Hyun, SW, Grigoryev, DN, et al. TNF-alpha increases tyrosine phosphorylation of vascular endothelial cadherin and opens the paracellular pathway through fyn activation in human lung endothelia. Am J Physiol Lung Cell Mol Physiol 2006;291:L1232–45.CrossRefGoogle ScholarPubMed
Schwarz, MA.Acute lung injury: cellular mechanisms and derangements. Paediatr Respir Rev 2001;2:3–9.Google ScholarPubMed
Wendel, M, Giessmann, U, Behrend, P, et al. Inflammatory-activated microvascular endothelial cells regulate interlekin-8 and monocyte chemoattractant protein-1 expression of A549 cells in a paracrine fashion. Exp Lung Res 2008;34:85–100.CrossRefGoogle Scholar
Fan, J, Ye, RD, Malik, AB.Transcriptional mechanisms of acute lung injury. Am J Physiol Lung Cell Mol Physiol 2001;165:L1037–50.CrossRefGoogle Scholar
Williams, MC.Alveolar type I cells: molecular phenotype and development. Annu Rev Physiol 2003;65:669–95.CrossRefGoogle ScholarPubMed
Mason, RJ.Biology of alveolar type II cells. Respirology 2006;11(Suppl);S12–S15.CrossRefGoogle ScholarPubMed
Matthay, MA, Robriquet, L, Fang, X.Alveolar epithelium. Role in lung fluid balance and acute lung injury. Proc Am Thorac Soc 2005;2:206–13.CrossRefGoogle ScholarPubMed
Gropper, MA, Wiener-Kronish, J.The epithelium in acute lung injury/acute respiratory distress syndrome. Curr Opin Critical Care 2008;14:11–15.CrossRefGoogle ScholarPubMed
Hales, CA, Du, HK, Volokhov, A, Mourfarrej, R, Quinn, DA.Aquaporin channels may modulate ventilator-induced lung injury. Respir Physiol 2001;124:159–66.CrossRefGoogle ScholarPubMed
Pugin, J, Verghese, G, Widmer, M-C, Widmaz, MC, Matthay, MA.The alveolar space is the site of intense inflammatory and profibrotic reactions in the early phase of ARDS. Am Rev Resp Dis 1997;272:L442–51.Google Scholar
Weiland, JE, Davis, B, Holter, JF, et al. Lung neutrophils in the adult respiratory distress syndrome: clinical and pathophysiological significance. Am Rev Respir Dis 1986;133:218–25.Google Scholar
Ranieri, VM, Suter, PM, Tortorella, C, et al. Effect of mechanical ventilation on inflammatory mediators in patient with acute respiratory distress syndrome. JAMA 1999;282:54–61.CrossRefGoogle ScholarPubMed
Agrawal, R, Srinivas, R, Agrawal, AN, Gupt, D.Immunosuppresive therapy in lung injury due to paraquat poisoning: a meta analysis. Singapore Med J 2007;48:1000–5.Google Scholar
Weiss, SM, Lakshminaravan, S.Acute inhalation injury. Clin Chest Med 1994;15:103–16.Google ScholarPubMed
Kitamura, Y, Hashimoto, S, Mizuta, N, et al. Fas/FasL-dependent apoptosis of alveolar cells after lipopolysaccharide- induced lung injury in mice. Am J Respir Crit Care Med 2001;163:762–9.CrossRefGoogle ScholarPubMed
Pittet, J-F, Wiener-Kronish, JP, McElroy, MC, Folkesson, HG, Matthay, MA.Stimulation of lung epithelial liquid clearance by endogenous release of catecholamines in septic shock in anaesthetised rats. J Clin Invest 1994;94:663–71.CrossRefGoogle Scholar
Sakuma, T, Folkesson, HG, Suzuki, S, et al. Beta-adrenergic agonist stimulated alveolar fluid clearance in ex-vivo human and rat lungs. Am J Respir Crit Care Med 1997;155:506–12.CrossRefGoogle ScholarPubMed
Matthay, MA, Wiener-Kronish, JP.Intact epithelial barrier function is critical for the resolution of alveolar edema in humans. Am Rev Respir Dis 1990;142:1250–7.CrossRefGoogle ScholarPubMed
Hu, P, Ischiropoulos, H, Beckman, JS, Matalon, S.Peroxynitrite inhibition of oxygen consumption and sodium transport in alveolar type II cells. Am J Physiol 1994;266:L628–34.Google ScholarPubMed
Chabot, F, Mitchell, JA, Gutteridge, JMC, Evans, TW.Reactive oxygen species in acute lung injury. Eur Respir J 1998;11:745–57.Google ScholarPubMed
Baudouin, SV.Surfactant medication for acute respiratory distress syndrome. Thorax 1997;52:S9–15.CrossRefGoogle ScholarPubMed
Idell, S, Gonzalez, K, Bradford, H, et al. Procoagulant activity in bronchoalveolar lavage in the adult respiratory distress syndrome. Am Rev Respir Dis 1987:136:1466–74.CrossRefGoogle ScholarPubMed
Idell, S, James, K, Levin, E, et al. Local abnormalities in coagulation and fibrinolytic pathways predispose to alveolar fibrin deposition in the adult respiratory distress syndrome. J Clin Invest 1989;84:695–705.CrossRefGoogle ScholarPubMed
Ware, LB, Matthay, MA.Lower plasma protein C is associated with worse clinical outcomes in patients with acute lung injury. Am J Respir Crit Care Med 2002;165:A476.Google Scholar
Bertozzi, P, Astedt, B, Zenzius, L, et al. Depressed bronchoalveolar urokinase activity in patients with adult respiratory distress syndrome. N Engl J Med 1990;322:890–7.CrossRefGoogle ScholarPubMed
Idell, S, Koenig, K, Fair, D, et al. Serial abnormalities of fibrin turnover in evolving adult respiratory distress syndrome. Am J Physiol 1991;261:L240–8.Google ScholarPubMed
Marshall, RP, Bellingan, G, Webb, S, et al. Fibroproliferation occurs early in the acute respiratory distress syndrome and impacts on outcome. Am J Respir Crit Care Med 2000;162:1783–8.CrossRefGoogle Scholar
Martinet, Y, Rom, WN, Grotendorst, GR, Martin, GR, Crystal, RG.Exaggerated spontaneous release of platelet-derived growth factor by alveolar macrophages from patients with idiopathic pulmonary fibrosis. N Engl J Med 1987;317:202–29.CrossRefGoogle ScholarPubMed
Rom, WN, Basset, P, Fells, GA, et al. Alveolar macrophages release an insulin-like growth factor 1-type molecule. J Clin Invest 1988;82:1685–93.CrossRefGoogle Scholar
Henke, C, Marineli, W, Jessurun, T, et al. Macrophage production of basic fibroblast growth factor in the fibroproliferative disorder of alveolar fibrosis after lung injury. Am J Pathol 1993;143:1189–99.Google ScholarPubMed
Snyder, LS, Hertz, MI, Paterson, MS, et al. Acute lung injury: pathogenesis of intralaveolar fibrosis. J Clin Invest 1991;88:663–73.CrossRefGoogle ScholarPubMed
Synenki, L, Chandel, NS, Budinger, GR, et al. Bronchoalveolar lavage fluid from patients with acute lung injury/acute respiratory distress syndrome induces myofibroblast differentiation. Crit Care Med 2007;35:842–8.CrossRefGoogle ScholarPubMed
Limper, AH, Roman, J.Fibronectin. A versatile matrix protein with roles in thoracic development, repair and infection. Chest 1992;101:1663–73.CrossRefGoogle ScholarPubMed
Meduri, GU, Tolley, EA, Chinn, A, Stentz, F, Postlethwaite, A.Procollagen types I and III propeptide levels rise during acute respiratory distress syndrome and in response to methylprednisilone treatment. Am J Respir Crit Care Med 1998;158:1432–41.CrossRefGoogle Scholar
Bensadoun, ES, Burke, AK, Hogg, JC, Roberts, CR.Proteglycan deposition in pulmonary fibrosis. Am J Respir Crit Care Med 1996;154:1819–28.CrossRefGoogle Scholar
Henke, C, Fiegel, V, Petersen, M, et al. Identification and partial characterisation of angiogenesis bioactivity in the lower respiratory tract after acute lung injury. J Clin Invest 1991;88:1386–95.CrossRefGoogle Scholar
Keane, MP, Donnelly, SC, Belperio, JA, et al. Imbalance in the expression of CXC chemokines correlates with bronchoalveolar lavage angiogenic activity and procollagen levels in acute respiratory distress syndrome. J Immunol 2002;169:6515–21.CrossRefGoogle ScholarPubMed
Thickett, DR, Armstrong, L, Christie, SJ, Millar, AB.Vascular endothelial growth factor may contribute to increased vascular permeability in acute respiratory distress syndromeAm J Respir Crit Care Med 2001;164:1601–5.CrossRefGoogle ScholarPubMed
Maitre, B, Boussat, S, Jean, D, et al. Vascular endothelial growth factor synthesis in the acute phase of experimental and clinical lung injury. Eur Respir J 2001;18:100–6.CrossRefGoogle ScholarPubMed
Geiser, T.Mechanisms of alveolar epithelial repair in acute lung injury – a translational approach. Swiss Med Wkly 2003;133:686–590.Google ScholarPubMed
Adamson, IYR, Young, L, Bowden, DH.Relationship of alveolar epithelial injury and repair to the induction of pulmonary fibrosis. Am J Pathol 1988;130:377–83.Google ScholarPubMed
Adamson, IYR, Hedgecock, C, Bowden, DH.Epithelial cell–fibroblast interactions in lung injury and repair. Am J Pathol 1990;137:385–92.Google ScholarPubMed
Kheradmand, F, Folkesson, HG, Shum, L, et al. Transforming growth factor-α enhances alveolar epithelial cell repair in a new in-vitro model. Am J Physiol Lung Cell Mol Physiol 1994;267:L728–38.CrossRefGoogle Scholar
Ulich, TR, Yi, ES, et al. Keratinocyte growth factor is a growth factor for alveolar type II pneumocytes in-vivo. J Clin Invest 1994;93:1298–306.CrossRefGoogle ScholarPubMed
Ohmichi, H, Matsumoto, K, Nakamura, T.In vivo mitogenic action of HGF on lung epithelial cells: pulmotrophic role in lung regeneration. Am J Physiol Lung Cell Mol Physiol 1996;270:L1031–9.CrossRefGoogle ScholarPubMed
Verghese, GM, McCormick-Shannon, K, Mason, RJ, Matthay, MA.Hepatocyte growth factor and keratinocyte growth factor in the pulmonary oedema fluid of patients with acute lung injury. Am J Respir Crit Care Med 1998;158:386–94.CrossRefGoogle ScholarPubMed
Barazzone, C, Donati, YR, Rochat, AF, et al. Keratinocyte growth factor protects the alveolar epithelium and endothelium from oxygen induced injury in mice. Am J Pathol 1999;154:1479–87.CrossRefGoogle ScholarPubMed
Baum, CL, Arpey, CJ.Normal cutaneous wound healing: clinical correlation with cellular and molecular events. Dermatol Surg 2005;31:674–86.CrossRefGoogle ScholarPubMed
Bellingan, GJ.The pulmonary physician in critical care: the pathogenesis of ALI/ARDS. Thorax 2002;57:540–6.CrossRefGoogle ScholarPubMed
Marshall, R, Bellingan, G, Laurent, G.The acute respiratory distress syndrome: fibrosis in the fast lane. Thorax 1998;53:815–17.CrossRefGoogle ScholarPubMed
Wallace, WAH, Fitch, PM, Simpson, AJ, Howie, SE.Inflammation associated remodelling and fibrosis in the lung – a process and an end point. Int J Exp Path 2007;88:103–10.CrossRefGoogle Scholar
McHugh, LG, Milberg, JA, Whitcome, ME, et al. Recovery of function in survivors of the acute respiratory distress syndrome. Am J Respir Crit Care Med 1994;150:90–4.CrossRefGoogle ScholarPubMed
Bellingan, GJ, Marshall, RP, Laurent, GJ.Fibrosis in ARDS: how close is the link between inflammation and fibroproliferation? In Vincent, JL, ed. Year Book of Intensive Care and Emergency Medicine. Berlin: Springer, 2000. pp. 217–24.Google Scholar
Matute-Bello, G, Liles, WC, Radella, F, et al. Neutrophil apoptosis in the acute respiratory distress syndrome. Am J Respir Crit Care Med 1997;156:1969–77.CrossRefGoogle ScholarPubMed
Cocker, RK, Laurent, GJ.Pulmonary fibrosis: cytokines in the balance. Eur Respir J 1998;11:1218–21.CrossRefGoogle Scholar
Matthay, MA, Wiener-Kronish, JP.Intact epithelial barrier function is critical for the resolution of alveolar oedema in humans. Am Rev Respir Dis 1990;142:1250–7.CrossRefGoogle ScholarPubMed
Kuwano, K, Hagimoto, N, Nakanishi, Y.The role of apoptosis in pulmonary fibrosis. Histol Histopathol 2004;19:867–81.Google ScholarPubMed
Ricou, B, Nicod, L, Lacraz, S, et al. Matrix metalloproteinases and TIMP in acute respiratory distress syndrome. Am J Respir Crit Care Med 1996;154:346–52.CrossRefGoogle ScholarPubMed
Anderson, WR, Thielen, K.Correlative study of adult respiratory distress syndrome by light, scanning and transmission electron microscopy. Ultrastruct Pathol 1992;16:615–28.CrossRefGoogle ScholarPubMed
Moloney, ED, Griffiths, MJ.Protective ventilation of patients with acute respiratory distress syndrome. Br J Anaesth 2004;92:261–70.CrossRefGoogle ScholarPubMed
dos Santos, CC, Slutsky, AC.Protective ventilation of patients with acute respiratory distress syndrome. Crit Care 2004;8:145–7.CrossRefGoogle ScholarPubMed
Bauer, TT, Ewig, S, Rodloff, AC, Müller, EE.Acute respiratory distress syndrome and pneumonia: a comprehensive review of clinical data. Clin Infect Dis 2006;43:748–56.CrossRefGoogle ScholarPubMed
Iregui, MG, Kollef, MH.Ventilator-associated pneumonia complicating the acute respiratory distress syndrome. Semin Respir Crit Care Med 2001;22:317–26.CrossRefGoogle ScholarPubMed
Dellinger, RP, Levy, MM, Carlet, JM, et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008;36:296–327.CrossRefGoogle ScholarPubMed
Bernard, GR, Vincent, JL, Laterre, PF, et al. Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001;344:699–709.CrossRefGoogle Scholar
Houston, G, Cuthbertson, BH.Activated protein C for the treatment of severe sepsis. Clin Microbiol Infect 2009;15:319–24.CrossRefGoogle ScholarPubMed
Mandell, LA, Wunderink, RG, Anzueto, A, et al. Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis 2007;44 (Suppl 2):S27–S72.CrossRefGoogle Scholar
Lim, WS, Baudouin, SV, George, RC, et al. British Thoracic Society guidelines for the management of community acquired pneumonia in adults: update 2009. Thorax 2009;64 Suppl 3:iii1–55.CrossRefGoogle Scholar
American Thoracic Society/Infectious Disease Society of America. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 2005;171:388–416.CrossRefGoogle Scholar
Masterton, RG, Galloway, A, French, G, et al. Guidelines for the management of hospital-acquired pneumonia in the UK. J Antimicrob Chemother 2008;62:5–34.CrossRefGoogle ScholarPubMed
Rotstein, C, Evans, G, Born, A, et al. Clinical practice guidelines for hospital-acquired pneumonia and ventilator-associated pneumonia in adults. Can J Infect Dis Med Microbiol 2008;19:19–53.Google ScholarPubMed
The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volume as compared with traditional tidal volumes for acute lung injury and acute respiratory distress syndrome. N Engl J Med 2000;342:1301–8.CrossRefGoogle Scholar
Adhikari, N, Burns, KE, Meade, MO.Pharmacologic therapy for adults with acute lung injury and acute respiratory distress syndrome. Cochrane Database Syst Rev 2004;4:CD004477.Google Scholar
Meduri, GU, Headley, AS, Golden, E, et al. Effect of prolonged methylprednisolone therapy in unresolving acute respiratory distress syndrome: a randomized controlled trial. JAMA 1998;280:159–65.CrossRefGoogle ScholarPubMed
Annane, D, Sébille, V, Bellissant, E, Ger-Inf-05 Study Group. Effect of low doses of corticosteroids in septic shock patients with or without early acute respiratory distress syndrome. Crit Care Med 2006;34:22–30.CrossRefGoogle ScholarPubMed
Steinberg, KP, Hudson, LD, Goodman, RB, et al. Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome. N Engl J Med 2006;354:1671–84.Google ScholarPubMed
Meduri, GU, Golden, E, Freire, AX, et al. Methylprednisolone infusion in early severe ARDS: results of a ranomized controlled trial. Chest 2007;131:954–63.CrossRefGoogle Scholar
Deal, EN, Hollands, JM, Schramm, GE, Micek, ST.Role of corticosteroids in the management of acute respiratory distress syndrome. Clin Ther 2008;30:787–99.CrossRefGoogle ScholarPubMed
Peter, JV, John, P, Graham, PL, et al. Corticosteroids in the prevention and treatment of acute respiratory distress syndrome (ARDS) in adults: meta-analysis. BMJ 2008;336:1006–9.CrossRefGoogle ScholarPubMed
Meduri, GU, Marik, PE, Chrousos, GP, et al. Steroid treatment in ARDS: a critical appraisal of the ARDS network trial and the recent literature. Intensive Care Med 2008;34:61–9.CrossRefGoogle ScholarPubMed
Ardizzoia, A, Lissoni, P, Tancini, G, et al. Respiratory distress syndrome in patients with advanced cancer treated with pentoxifylline: a randomized study. Support Care Cancer 1993;1:331–3.CrossRefGoogle ScholarPubMed
Anzueto, A, Baughman, RP, Guntupalli, KK, et al. Aerosolized surfactant in adults with sepsis-induced acute respiratory distress syndrome. Exosurf Acute Respiratory Distress Syndrome Sepsis Study Group. N Engl J Med 1996;334:1417–21.CrossRefGoogle ScholarPubMed
Spragg, RG, Lewis, JF, Walmrath, HD, et al. Effect of recombinant surfactant protein C-based surfactant on the acute respiratory distress syndrome. N Engl J Med 2004;351:884–92.CrossRefGoogle ScholarPubMed
Taylor, RW, Zimmermann, JL, Dellinger, RP, et al. Low-dose inhaled nitric oxide in patients with acute lung injury: a randomized controlled trial. JAMA 2004;291:1603–9.CrossRefGoogle ScholarPubMed
Abraham, E, Baughman, R, Fletcher, E, et al. Liposomal prostaglandin E1 (TLC C-53) in acute respiratory distress syndrome: a controlled, randomized, double-blind, multicenter clinical trial. TLC C-53 ARDS Study Group. Crit Care Med 1999;27:1478–85.CrossRefGoogle ScholarPubMed
The ARDS Network. Ketoconazole for early treatment of acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. The ARDS Network. JAMA 2000;283:1995–2002.CrossRefGoogle Scholar
Bernard, GR, Wheeler, AP, Arons, MM, et al. A trial of antioxidants N-acetylcysteine and procysteine in ARDS. The Antioxidant in ARDS Study Group. Chest 1997;112:164–72.CrossRefGoogle ScholarPubMed
Domenighetti, G, Suter, PM, Schaller, MD, Ritz, R, Perret, C.Treatment with N-acetylcysteine during acute respiratory distress syndrome: a randomized, double-blind, placebo-controlled clinical study. J Crit Care 1997;12:177–82.CrossRefGoogle ScholarPubMed
Zeiher, BG, Artigas, A, Vincent, JL, et al. STRIVE Study Group. Neutrophil elastase inhibition in acute lung injury: results of the STRIVE study. Crit Care Med 2004;32:1695–702.CrossRefGoogle Scholar
Perkins, GD, McAuley, DF, Thickett, DR, Gao, F.The beta agonist lung injury trial (BALTI): a randomised placebo controlled clinical trial. Am J Respir Crit Care Med 2006;173:281–7.CrossRefGoogle Scholar
Liu, KD, Levitt, J, Zhuo, H, et al. Randomized clinical trial of activated protein C for the treatment of acute lung injury. Am J Respir Crit Care Med 2008;178:618–23.CrossRefGoogle ScholarPubMed
Shyamsundar, M, McKeown, ST, O'Kane, CM, et al. Simvastatin decreases lipopolysaccharide induced pulmonary inflammation in healthy volunteers. Am J Respir Crit Care Med 2009;179:1107–14.CrossRefGoogle ScholarPubMed
Rossi, AG, Sawatzky, DA, Walker, A, et al. Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis. Nat Med 2006;12:1056–64.CrossRefGoogle ScholarPubMed
Hoogerwerf, JJ, de Vos, AF, Levi, M, et al. Activation of coagulation and inhibition of fibrinolysis in the human lung on bronchial instillation of lipoteichoic acid and lipopolysaccharide. Crit Care Med 2009;37:619–25.CrossRefGoogle ScholarPubMed
Richard, C, Warszawski, J, Anguel, N, et al. French Pulmonary Artery Catheter Study Group. Early use of the pulmonary artery catheter and outcome in patients with shock and acute respiratory distress syndrome: a randomized controlled trial. JAMA 2003;290:2713–20.CrossRefGoogle Scholar
Wheeler, AP, Bernard, GR, Thompson, BT, et al. Pulmonary-artery versus central venous catheter to guide treatment of acute lung injury. N Engl J Med 2006;354:2213–24.Google ScholarPubMed
Wiedermann, HP, Wheeler, AP, Bernard, GR, et al. Comparison of two fluid-management strategies in acute lung injury. N Engl J Med 2006;354:2564–75.Google Scholar
Gattinoni, L, Tognoni, G, Pesenti, A, et al. Prone-Supine Study Group. Effect of prone positioning on the survival of patients with acute respiratory distress syndrome. N Engl J Med 2001;345:568–73.CrossRefGoogle Scholar
Mancebo, J, Fernández, R, Blanch, L, et al. A multicenter trial of prolonged prone ventilation in severe acute respiratory distress syndrome. Am J Respir Crit Care Med 2006;173:1233–39.CrossRefGoogle ScholarPubMed
Fernandez, R, Trenchs, X, Klamburg, J, Castedo, J, Serrano, JM, Besso, G, et al. Prone positioning in acute respiratory distress syndrome: a multicenter randomized clinical trial. Intensive Care Med 2008;34:1487–91.CrossRefGoogle ScholarPubMed
Dreyfuss, D, Soler, P, Basset, G, Saumon, G.High inflation pressure pulmonary edema. Respective effects of high airway pressure, high tidal volume and positive end-expiratory pressure. Am Rev Respir Dis 1988;137:1159–64.CrossRefGoogle ScholarPubMed
Brower, RG, Lanken, PN, Macintyre, N, et al. Higher versus lower positive end-expiratory pressure in patients with the acute respiratory distress syndrome. N Engl J Med 2004;351:327–36.Google ScholarPubMed
Talmor, D, Sarge, T, Malhotra, A, et al. Mechanical ventilation guided by esophageal pressure in acute lung injury. N Engl J Med 2008;359:2095–104.CrossRefGoogle ScholarPubMed

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