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Chapter 23 - Immunodeficiency-Associated Lymphoproliferative Disorders

from Section V - Mature Lymphoid Neoplasms

Published online by Cambridge University Press:  25 January 2024

By
Xiayuan Liang
Edited by
Xiayuan Liang ,
Bradford Siegele  and
Jennifer Picarsic
Xiayuan Liang
Affiliation:
Children’s Hospital of Colorado
Bradford Siegele
Affiliation:
Children’s Hospital of Colorado
Jennifer Picarsic
Affiliation:
Cincinnati Childrens Hospital Medicine Center
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Summary

Immunodeficiency is a state of reduced ability to produce an adequate immune response due to an insufficiency or absence of antibodies, immune cells, or both. Immunodeficiency disorders can be primary (inherited/congenital) or acquired. Acquired immunodeficiencies can result from HIV infection, solid organ or hematopoietic stem cell transplantation, and other iatrogenic conditions, such as chemotherapy.

Immunodeficiency is associated with an increased risk of benign and malignant lymphoproliferative disorders (LPDs) [1]. As a result, a wide range of clinical manifestations and diseases can develop. Pathologists may face a challenge in making an accurate diagnosis and classification of lesion tissues from these patients because of the different nature of their immune systems in this context. Therefore, it is important that the pathologist be informed of the underlying condition when evaluating specimens from these patients [1].

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Chapter
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Pediatric Pathology of Hematopoietic and Histiocytic Disorders , pp. 296 - 306
Publisher: Cambridge University Press
Print publication year: 2024

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References

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