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Case 90 - Large Cell Neuroendocrine Carcinoma of the Larynx

Published online by Cambridge University Press:  19 November 2019

By
Llucia Alos  and
Paola Castillo
Edited by
Alessandro Franchi
Alessandro Franchi
Affiliation:
Università degli Studi di Firenze, Italy
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Summary

A 76-year-old male, a smoker, presented with a supraglottic laryngeal tumor that was excised.

Type
Chapter
Information
Pearls and Pitfalls in Head and Neck Pathology , pp. 183 - 184
Publisher: Cambridge University Press
Print publication year: 2019

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References

El-Naggar, AK, Chan, JKC, Grandis, JR, Takata, T, Slootweg, PJ, eds. WHO classification of head and neck tumours, 4th ed. Lyon: International Agency for Research on Cancer; 2017, 347pp.Google Scholar
Lewis, JS, Ferlito, A, Gnepp, DR, Rinaldo, A, Devaney, KO, Silver, CE, et al. Terminology and classification of neuroendocrine neoplasms of the larynx. The Laryngoscope. 2011;121:1187–1193.CrossRefGoogle ScholarPubMed
Lewis, JS, Spence, DC, Chiosea, S, Barnes, EL, Brandwein-Gensler, M, El-Mofty, SK. Large cell neuroendocrine carcinoma of the larynx: definition of an entity. Head Neck Pathol. 2010;4:198–207.CrossRefGoogle ScholarPubMed
Kao, H-L, Chang, W-C, Li, W-Y, Chia-Heng Li, A, Fen-Yau, Li A. Head and neck large cell neuroendocrine carcinoma should be separated from atypical carcinoid on the basis of different clinical features, overall survival, and pathogenesis. Am J Surg Pathol. 2012;36:185–192.CrossRefGoogle ScholarPubMed
Alos, L, Hakim, S, Larque, A-B, de la Oliva, J, Rodriguez-Carunchio, L, Caballero, M, et al. p16 overexpression in high-grade neuroendocrine carcinomas of the head and neck: potential diagnostic pitfall with HPV-related carcinomas. Virchows Archiv. 2016;469:277–284.CrossRefGoogle ScholarPubMed

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