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Chapter 12 - Fetal Cardiovascular Disease

Published online by Cambridge University Press:  19 August 2019

Michael T. Ashworth
Affiliation:
Great Ormond Street Hospital for Children, London
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Summary

The chapter opens with observations on the normal fetal heart and proceeds to a discussion of fetal hydrops and its associated cardiac causes. There follows a treatment of the syndromes associated with congenital heart disease in the fetus. Common congenital heart defects as they appear in the fetus are illustrated. Fetal cardiomyopathy, myocarditis and arrhythmia all have separate discussions. The chapter closes with a series of discussions on the pathology of twins as it affects the heart: twin–twin transfusion syndrome, conjoined twins and acardiac twins.

Type
Chapter
Information
Pathology of Heart Disease in the Fetus, Infant and Child
Autopsy, Surgical and Molecular Pathology
, pp. 252 - 282
Publisher: Cambridge University Press
Print publication year: 2019

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References

Hoffman, JI, Kaplan, S. The incidence of congenital heart disease. J Am Coll Cardiol 2002; 39: 18901900.CrossRefGoogle ScholarPubMed
Gill, HK, Splitt, M, Sharland, GK, Simpson, JM. Patterns of recurrence of congenital heart disease: an analysis of 6,640 consecutive pregnancies evaluated by detailed fetal echocardiography. J Am Coll Cardiol 2003; 42: 923929.CrossRefGoogle Scholar
Donofrio, MT, Moon-Grady, AJ, Hornberger, LK et al.; American Heart Association Adults With Congenital Heart Disease Joint Committee of the Council on Cardiovascular Disease in the Young and Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and Council on Cardiovascular and Stroke Nursing. Diagnosis and treatment of fetal cardiac disease: a scientific statement from the American Heart Association. Circulation 2014; 129: 21832242.Google Scholar
Hernandez-Andrade, E, Patwardhan, M, Cruz-Lemini, M, Luewan, S. Early evaluation of the fetal heart. Fetal Diagn Ther 2017; 42: 161173.CrossRefGoogle ScholarPubMed
Rodriguez, JG, Holmes, R, Martin, R, Wilde, P, Soothill, P. Prognosis following prenatal diagnosis of heart malformations. Early Hum Dev 1998; 52: 1320.CrossRefGoogle ScholarPubMed
Hornberger, LK, Sanders, SP, Rein, AJ et al. Left heart obstructive lesions and left ventricular growth in the midtrimester fetus: a longitudinal study. Circulation 1995; 92: 15311538.Google Scholar
Maeno, YV, Boutin, C, Hornberger, LK et al. Prenatal diagnosis of right ventricular outflow tract obstruction with intact ventricular septum, and detection of ventriculocoronary connections. Heart 1999; 81: 661668.Google Scholar
Allan, LD, Sharland, GK, Milburn, A et al. Prospective diagnosis of 1,006 consecutive cases of congenital heart disease in the fetus. J Am Coll Cardiol 1994; 23: 14521458.CrossRefGoogle Scholar
Hoffman, JIE. Incidence of congenital heart disease, II: prenatal incidence. Pediatr Cardiol 1995; 16: 155165.CrossRefGoogle ScholarPubMed
Eronen, M. Outcome of fetuses with heart disease diagnosed in utero. Arch Dis Child 1997; 77: F41F46.CrossRefGoogle ScholarPubMed
Tanner, K, Sabrine, N, Wren, C. Cardiovascular malformations among preterm infants. Pediatrics 2005; 116: e833–838.CrossRefGoogle ScholarPubMed
Yates, RS. The influence of prenatal diagnosis on postnatal outcome in patients with structural congenital heart disease. Prenat Diagn 2004; 24: 11431149.Google Scholar
Godfrey, ME, Messing, B, Cohen, SM, Valsky, DV, Yagel, S. Functional assessment of the fetal heart: a review. Ultrasound Obstet Gynecol 2012; 39: 131144.CrossRefGoogle ScholarPubMed
Johnson, P, Maxwell, DJ, Tynan, MJ, Allan, LD. Intracardiac pressures in the human fetus. Heart 2000; 84: 5963.CrossRefGoogle ScholarPubMed
Kiserud, T, Ebbing, C, Kessler, J, Rasmussen, S. Fetal cardiac output, distribution to the placenta and impact of placental compromise. Ultrasound Obstet Gynecol 2006; 28: 126136.Google Scholar
Jonker, SS, Zhang, L, Louey, S et al. Myocyte enlargement, differentiation, and proliferation kinetics in the fetal sheep heart. J Appl Physiol 2007; 102: 11301142.CrossRefGoogle ScholarPubMed
Kowalski, WJ, Pekkan, K, Tinney, JP, Keller, BB. Investigating developmental cardiovascular biomechanics and the origins of congenital heart defects. Front Physiol 2014; 5: 408.Google Scholar
Russell, B, Curtis, MW, Koshman, YE, Samarel, AM. Mechanical stress-induced sarcomere assembly for cardiac muscle growth in length and width. J Mol Cell Cardiol 2010; 48: 817823.CrossRefGoogle ScholarPubMed
Jouk, PS, Usson, Y, Michalowicz, G, Grossi, L. Three-dimensional cartography of the pattern of the myofibres in the second trimester fetal human heart. Anat Embryol (Berl) 2000; 202: 103118.Google Scholar
Bellini, C, Hennekam, RC. Non-immune hydrops fetalis: a short review of etiology and pathophysiology. Am J Med Genet A 2012; 158A: 597605.CrossRefGoogle Scholar
McFadden, DE, Taylor, GP. Cardiac abnormalities and nonimmune hydrops fetalis: coincidental, not causal, relationship. Pediatr Pathol 1989: 9: 1117.CrossRefGoogle Scholar
Clur, SA, Oude Rengerink, K, Ottenkamp, J, Bilardo, CM. Cardiac function in trisomy 21 fetuses. Ultrasound Obstet Gynecol 2011; 37: 163171.Google Scholar
Hornberger, LK, Sahn, DJ, Kleinman, CS, Copel, JA, Reed, KL. Tricuspid valve disease with significant tricuspid insufficiency in the fetus: diagnosis and outcome. J Am Coll Cardiol 1991; 17: 167173.Google Scholar
Kawazu, Y, Inamura, N, Ishii, R et al. Prognosis in tetralogy of Fallot with absent pulmonary valve. Pediatr Int 2015; 57: 210216.CrossRefGoogle ScholarPubMed
Bendadi, F, van Tijn, DA, Pistorius, L, Freund, MW. Chiari’s network as a cause of fetal and neonatal pathology. Pediatr Cardiol 2012; 33: 188191.Google Scholar
Terry, J, Tapas, M, Nowaczyk, MJ. Prenatal and pathologic features of aorto-left ventricular tunnel causing fetal hydrops and intrauterine demise. Pediatr Dev Pathol 2013; 16: 97101.Google Scholar
Armes, JE, Squires, L, Lourie, R et al. Isolated ventricular noncompaction cardiomyopathy presenting as fetal hydrops at 24 weeks gestation. Pediatr Dev Pathol 2017; 20: 245250.CrossRefGoogle ScholarPubMed
Yinon, Y, Chitayat, D, Blaser, S et al. Fetal cardiac tumors: a single-center experience of 40 cases. Prenat Diagn 2010; 30: 941949.Google Scholar
Izmirly, PM, Saxena, A, Kim, MY et al. Maternal and fetal factors associated with mortality and morbidity in a multi-racial/ethnic registry of anti-SSA/Ro-associated cardiac neonatal lupus. Circulation 2011; 124: 19271935.Google Scholar
Ornoy, A, Ergaz, Z. Parvovirus B19 infection during pregnancy and risks to the fetus. Birth Defects Res 2017; 109: 311323.Google Scholar
Enzensberger, C, Wienhard, J, Weichert, J et al. Idiopathic constriction of the fetal ductus arteriosus: three cases and review of the literature. J Ultrasound Med 2012; 31: 12851291.Google Scholar
Hagen, AAlbig, M, Schmitz, L et al. Prenatal diagnosis of isolated foramen ovale obstruction. A Report of Two Cases. Fetal Diagn Ther 2005; 20: 7073.Google Scholar
Moaddab, A, Tonni, G, Grisolia, G et al. Predicting outcome in 259 fetuses with agenesis of ductus venosus – a multicenter experience and systematic review of the literature. J Matern Fetal Neonatal Med 2016; 29: 36063614.Google Scholar
Cuneo, BF, Strasburger, JF, Wakai, RT. The natural history of fetal long QT syndrome. J Electrocardiol 2016; 49: 807813.CrossRefGoogle ScholarPubMed
Chong, CR, Hutchins, GM. Idiopathic infantile arterial calcification: the spectrum of clinical presentations. Pediatr Dev Pathol 2008; 11: 405415.Google Scholar
Cass, DL, Olutoye, OO, Ayres, NA et al. Defining hydrops and indications for open fetal surgery for fetuses with lung masses and vascular tumorsJ Pediatr Surg 2012; 47: 4045.Google Scholar
Axt-Fliedner, R, Kurkevych, A, Slodki, M et al.; International Prenatal Cardiology Collaboration Group. Absent pulmonary valve syndrome – diagnosis, associations, and outcome in 71 prenatally diagnosed cases. Prenat Diagn 2017; 37: 812819.Google Scholar
Siven, M, Ley, D, Hagerstrand, I, Svenningsen, N. Agenesis of the ductus venosus and its correlation to hydrops fetalis and the hepatic fetal circulation: case reports and review of the literature. Pediatr Pathol Lab Med 1995; 15: 3950.Google Scholar
Gewillig, M, Brown, SC, De Catte, L et al. Premature foetal closure of the arterial duct: clinical presentations and outcome. Eur Heart J 2009; 30: 15301536.CrossRefGoogle ScholarPubMed
Lopes, LM, Tavares, GM, Damiano, AP et al. Perinatal outcome of fetal atrioventricular block : one hundred-sixteen cases from a single institution. Circulation 2008; 118: 12681275.Google Scholar
Zhao, H, Cuneo, BF, Strasburger, JF et al. Electrophysiological characteristics of fetal atrioventricular block. J Am Coll Cardiol 2008; 51: 7784.CrossRefGoogle ScholarPubMed
Jaeggi, E, Laskin, C, Hamilton, R, Kingdom, J, Silverman, E. The importance of the level of maternal anti-Ro/SSA antibodies as a prognostic marker of the development of cardiac neonatal lupus erythematosus: a prospective study of 186 antibody-exposed fetuses and infants. J Am Coll Cardiol 2010; 55: 27782784.CrossRefGoogle ScholarPubMed
Llanos, C, Friedman, DM, Saxena, A et al. Anatomical and pathological findings in hearts from fetuses and infants with cardiac manifestations of neonatal lupus. Rheumatology 2012; 51: 10861092.Google Scholar
Krishnan, AN, Sable, CA, Donofrio, MT. Spectrum of fetal echocardiographic findings in fetuses of women with clinical or serologic evidence of systemic lupus erythematosus. J Matern Fetal Neonatal Med 2008; 21: 776782.Google Scholar
Hartman, RJ, Rasmussen, SA, Botto, LD et al. The contribution of chromosomal abnormalities to congenital heart defects: a population-based study. Pediatr Cardiol 2011; 32: 11471157.CrossRefGoogle ScholarPubMed
Mogra, R, Zidere, V, Allan, LD. Prenatally detectable congenital heart defects in fetuses with Down syndrome. Ultrasound Obstet Gynecol 2011; 38: 320324.Google Scholar
Irving, CA, Chaudhari, MP. Cardiovascular abnormalities in Down’s syndrome: spectrum, management and survival over 22 years. Arch Dis Child 2012; 97: 326330.Google Scholar
Paladini, D, Tartaglione, A, Agangi, A et al. The association between congenital heart disease and Down syndrome in prenatal life. Ultrasound Obstet Gynecol 2000; 15: 104108.Google Scholar
Rosenquist, GC, Sweeney, LJ, Amsel, J, McAllister, HA. Enlargement of the membranous ventricular septum: an internal stigma of Down’s syndrome. J Pediatr 1974; 85 : 490493.Google Scholar
Paladini, D, Sglavo, G, Pastore, G et al. Aberrant right subclavian artery: incidence and correlation with other markers of Down syndrome in second-trimester fetuses. Ultrasound Obstet Gynecol 2012; 39: 191195.Google Scholar
Fudge, JC Jr, Li, S, Jaggers, J et al. Congenital heart surgery outcomes in Down syndrome: analysis of a national clinical database. Pediatrics 2010; 126: 315322.CrossRefGoogle ScholarPubMed
Korbel, JO, Tirosh-Wagner, T, Urban, AE et al. The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies. Proc Natl Acad Sci U S A 2009; 106: 1203112036.Google Scholar
Moyano, D, Huggon, IC, Allan, LD. Fetal echocardiography in trisomy 18. Arch Dis Child Fetal Neonatal Ed 2005; 90: F520–522.Google Scholar
Van Praagh, S, Truman, T, Firpo, A et al. Cardiac malformations in trisomy-18: a study of 41 postmortem cases. J Am Coll Cardiol 1989; 13: 15861597.Google Scholar
Hyett, J, Moscoso, G, Nicolaides, K. Abnormalities of the heart and great arteries in first trimester chromosomally abnormal fetuses. Am J Med Genet 1997; 69: 207216.Google Scholar
McFadden, DE, Robinson, WP. Phenotype of triploid embryos. J Med Genet 2006; 43: 609612.CrossRefGoogle ScholarPubMed
Sergi, C, Schiesser, M, Adam, S, Otto, HF. Analysis of the spectrum of malformations in human fetuses of the second and third trimester of pregnancy with human triploidy. Pathologica 2000; 92: 257263.Google ScholarPubMed
Jauniaux, E, Brown, R, Rodeck, C, Nicolaides, KH. Prenatal diagnosis of triploidy during the second trimester of pregnancy. Obstet Gynecol 1996; 88: 983989.CrossRefGoogle ScholarPubMed
Kim, HK, Gottliebson, W, Hor, K et al. Cardiovascular anomalies in Turner syndrome: spectrum, prevalence, and cardiac MRI findings in a pediatric and young adult population. Am J Roentgenol 2011; 196: 454460.CrossRefGoogle Scholar
Mortensen, KH, Andersen, NH, Gravholt, CH. Cardiovascular phenotype in Turner syndrome – integrating cardiology, genetics, and endocrinology. Endocr Rev 2012; 33: 677714.CrossRefGoogle ScholarPubMed
Bondy, CA. Aortic dissection in Turner syndrome. Curr Opin Cardiol 2008; 23: 519526.Google Scholar
Shapira, SK, McCaskill, C, Northrup, H et al. Chromosome 1p36 deletions: the clinical phenotype and molecular characterization of a common newly delineated syndrome. Am J Hum Genet 1997; 61: 642650.CrossRefGoogle ScholarPubMed
Heilstedt, HA, Ballif, BC, Howard, LA, Kashork, CD, Shaffer, LG. Population data suggest that deletions of 1p36 are a relatively common chromosome abnormality. Clin Genet 2003; 64 : 310316.Google Scholar
von Elten, K, Sawyer, T, Lentz-Kapua, S, Kanis, A, Studer, M. A Case of Wolf-Hirschhorn syndrome and hypoplastic left heart syndrome. Pediatr Cardiol 2013; 34: 12441246.CrossRefGoogle ScholarPubMed
Chen, CP, Lin, SP, Chen, MR et al. Phenotypic features of pure 9p deletion in a male infant include cryptorchidism, congenital heart defects and postaxial polydactyly. Genet Couns 2012; 23: 195200.Google Scholar
Huang, C, Yang, YF, Yin, N et al. Congenital heart defect and mental retardation in a patient with a 13q33.1–34 deletion. Gene 2012; 498: 308310.Google Scholar
Versacci, P, Digilio, MC, Sauer, U, Dallapiccola, B, Marino, B. Absent pulmonary valve with intact ventricular septum and patent ductus arteriosus: a specific cardiac phenotype associated with deletion 18q syndrome. Am J Med Genet A 2005; 138A: 185186.CrossRefGoogle ScholarPubMed
Molesky, MG. Chromosome 22q11.2 microdeletion syndrome. Neonatal Netw 2011; 30: 304311.Google Scholar
Vajro, P, Ferrante, L, Paolella, G. Alagille syndrome: an overview. Clin Res Hepatol Gastroenterol 2012; 36: 275277.Google Scholar
Subramaniam, P, Knisely, A, Portmann, B et al. Diagnosis of Alagille syndrome – 25 years of experience at King’s College Hospital. J Pediatr Gastroenterol Nutr 2011; 52: 8489.CrossRefGoogle ScholarPubMed
McElhinney, DB, Krantz, ID, Bason, L et al. Analysis of cardiovascular phenotype and genotype-phenotype correlation in individuals with a JAG1 mutation and/or Alagille syndrome. Circulation 2002; 106: 25672574.CrossRefGoogle ScholarPubMed
Bergman, JE, Janssen, N, Hoefsloot, LH et al. CHD7 mutations and CHARGE syndrome: the clinical implications of an expanding phenotype. J Med Genet 2011; 48: 334342.Google Scholar
Zentner, GE, Layman, WS, Martin, DM, Scacheri, PC. Molecular and phenotypic aspects of CHD7 mutation in CHARGE syndrome. Am J Med Genet A 2010: 152A: 674686.Google Scholar
Lin, AE, Chin, AJ, Devine, W, Park, SC, Zackai, E. The pattern of cardiovascular malformation in the CHARGE association. Am J Dis Child 1987; 141: 10101013.Google Scholar
Rohrer, T. Noonan syndrome: introduction and basic clinical features. Horm Res 2009; 72 (Suppl 2): 37.Google Scholar
Denayer, E, Peeters, H, Sevenants, L et al. NRAS mutations in Noonan syndrome. Mol Syndromol 2012; 3: 3438.Google Scholar
Sreeram, N, Kitchener, D, Smith, A. Spectrum of valvular abnormalities in Noonan’s syndrome – a pathologic study. Cardiol Young 1994; 4: 6266.Google Scholar
Morris, CA, Mervis, CB. Williams syndrome and related disorders. Annu Rev Genomics Hum Genet 2000; 1: 461484.Google Scholar
Collins, RT, Aziz, PF, Gleason, MM, Kaplan, PB, Shah, MJ. Abnormalities of cardiac repolarization in Williams syndrome. Am J Cardiol 2010; 106: 10291033.CrossRefGoogle ScholarPubMed
Eronen, M, Peippo, M, Hiippala, A et al. Cardiovascular manifestations in 75 patients with Williams syndrome. J Med Genet 2002; 39: 554558.CrossRefGoogle ScholarPubMed
Li, DY, Toland, AE, Boak, BB et al. Elastin point mutations cause an obstructive vascular disease, supravalvular aortic stenosis. Hum Mol Genet 1997; 6: 10211028.CrossRefGoogle ScholarPubMed
Yuan, SM, Jing, H. Marfan’s syndrome: an overview. Sao Paulo Med J 2010; 128: 360366.Google Scholar
Phornphutkul, C, Rosenthal, A, Nadas, AS. Cardiac manifestations of Marfan syndrome in infancy and childhood. Circulation 1973; 47: 587596.Google Scholar
van Karnebeek, CD, Naeff, MS, Mulder, BJ, Hennekam, RC, Offringa, M. Natural history of cardiovascular manifestations in Marfan syndrome. Arch Dis Child 2001; 84: 129137.Google Scholar
Solomon, BD. VACTERL/VATER Association. Orphanet J Rare Dis 2011; 6: 56.CrossRefGoogle ScholarPubMed
Newbury-Ecob, RA, Leanage, R, Raeburn, JA, Young, ID. Holt-Oram syndrome: a clinical genetic study. J Med Genet 1996; 33: 300307.Google Scholar
Li, QY, Newbury-Ecob, RA, Terrett, JA et al. Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family. Nat Genet 1997; 15: 2129.Google Scholar
Stratakis, CA, Kirschner, LS, Carney, JA. Clinical and molecular features of the Carney complex: diagnostic criteria and recommendations for patient evaluation. J Clin Endocrinol Metab 2001; 86: 40414046.Google Scholar
Loeys, BL, Schwarze, U, Holm, T et al. Aneurysm syndromes caused by mutations in the TGF-beta receptor. N Engl J Med 2006; 355: 788798.CrossRefGoogle ScholarPubMed
Maleszewski, JJ, Miller, DV, Lu, J, Dietz, HC, Halushka, MK. Histopathologic findings in ascending aortas from individuals with Loeys-Dietz syndrome (LDS). Am J Surg Pathol 2009; 33: 194201.Google Scholar
Pepin, M, Schwarze, U, Superti-Furga, A, Byers, PH. Clinical and genetic features of Ehlers–Danlos syndrome type IV, the vascular type. N Engl J Med 2000; 342: 673680.Google Scholar
Haitas, B, Baker, SG, Meyer, TE, Joffe, BI, Seftel, HC. Natural history and cardiac manifestations of homozygous familial hypercholesterolaemia. Q J Med 1990; 76: 731740.Google ScholarPubMed
Rallidis, L, Naoumova, RP, Thompson, GR, Nihoyannopoulos, P. Extent and severity of atherosclerotic involvement of the aortic valve and root in familial hypercholesterolaemia. Heart 1998; 80: 583590.Google Scholar
Pedra, SR, Smallhorn, JF, Ryan, G et al. Fetal cardiomyopathies: pathogenic mechanisms, hemodynamic findings, and clinical outcome. Circulation 2002; 106: 585591.Google Scholar
Mongiovì, M, Fesslova, V, Fazio, G, Barbaro, G, Pipitone, S. Diagnosis and prognosis of fetal cardiomyopathies: a review. Curr Pharm Des 2010; 16: 29292934.CrossRefGoogle ScholarPubMed
Fesslova, V, Mongiovì, M, Pipitone, S, Brankovic, J, Villa, L. Features and outcomes in utero and after birth of fetuses with myocardial disease. Int J Pediatr 2010; 2010: 628451.Google Scholar
Tsapakis, EG, Eleftheriades, M, Daskalakis, G, Chrelias, C, Hassiakos, D. Prenatal diagnosis of fetal left ventricular non-compaction cardiomyopathy. Ultrasound Obstet Gynecol 2012; 39: 592594.Google Scholar
Martins, Y, Silva, S, Matias, A, Blickstein, I. Cardiac morbidity in twin–twin transfusion syndrome? J Perinat Med 2012; 40: 107114.Google Scholar
Stirnemann, JJ, Mougeot, M, Proulx, F et al. Profiling fetal cardiac function in twin–twin transfusion syndrome. Ultrasound Obstet Gynecol 2010; 35: 1927.Google Scholar
Sivasankaran, S, Sharland, GK, Simpson, JM. Dilated cardiomyopathy presenting during fetal life. Cardiol Young 2005; 15: 409416.CrossRefGoogle ScholarPubMed
Corrigan, N, Brazil, DP, McAuliffe, F. Fetal cardiac effects of maternal hyperglycemia during pregnancy. Birth Defects Res A Clin Mol Teratol 2009; 85: 523530.Google Scholar
Steward, CG, Newbury-Ecob, RA, Hastings, R et al. Barth syndrome: an X-linked cause of fetal cardiomyopathy and stillbirth. Prenat Diagn 2010; 30: 970976.CrossRefGoogle ScholarPubMed
Hinton, RB, Michelfelder, EC, Marino, BS, Bove, KE, Ware, SM. A fetus with hypertrophic cardiomyopathy, restrictive, and single-ventricle physiology, and a beta-myosin heavy chain mutation. J Pediatr 2010; 157: 164166.CrossRefGoogle Scholar
Moura, C, Hillion, Y, Daikha-Dahmane, F et al. Isolated non-compaction of the myocardium diagnosed in the fetus: two sporadic and two familial cases. Cardiol Young 2002; 12: 278283.CrossRefGoogle ScholarPubMed
Karatza, AA, Holder, SE, Gardiner, HM. Isolated non-compaction of the ventricular myocardium: prenatal diagnosis and natural history. Ultrasound Obstet Gynecol 2003; 21: 7580.Google Scholar
Crane, J, Mundle, W, Boucoiran, I; Maternal Fetal Medicine Committee. Parvovirus B19 infection in pregnancy. J Obstet Gynaecol Can 2014; 36: 11071116.CrossRefGoogle ScholarPubMed
Berry, PJ, Gray, ES, Porter, HJ, Burton, PA. Parvovirus infection of the human fetus and newborn. Semin Diagn Pathol 1992; 9: 412.Google Scholar
Towbin, JA, Griffin, LD, Martin, AB et al. Intrauterine adenoviral myocarditis presenting as nonimmune hydrops fetalis: diagnosis by polymerase chain reaction. Pediatr Infect Dis J 1994; 13: 144150.Google Scholar
Ramalho, C, Monterroso, J, Simões, J, Brandão, O, Montenegro, N. Human herpes virus 6 causing myocarditis in a fetus: an infectious cause to a congenital heart defect. J Clin Pathol 2011; 64: 733734.Google Scholar
Ona, MA, Bashari, DR, Tharayil, Z et al. A case of fatal fulminant myocarditis presenting as an acute ST-segment elevation myocardial infarction and persistent ventricular tachyarrhythmia associated with influenza A (H1N1) virus in a previously healthy pregnant woman. Cardiology 2012; 123: 103107.Google Scholar
Ornoy, A, Dudai, M, Sadovsky, E. Placental and fetal pathology in infectious mononucleosis. A possible indicator for Epstein–Barr virus teratogenicity. Diagn Gynecol Obstet 1982; 4: 1116.Google ScholarPubMed
Okumura, M, Aparecida dos Santos, V, Camargo, ME, Schultz, R, Zugaib, M. Prenatal diagnosis of congenital Chagas’ disease (American trypanosomiasis). Prenat Diagn 2004; 24: 179181.Google Scholar
Soulié, JC. Cardiac involvement in fetal parvovirus B19 infection. Pathol Biol (Paris) 1995; 43: 416419.Google Scholar
Hornberger, LK, Sahn, DJ. Rhythm abnormalities of the fetus. Heart 2007; 93: 12941300.Google Scholar
Wacker-Gussmann, A, Strasburger, JF, Cuneo, BF, Wakai, RT. Diagnosis and treatment of fetal arrhythmia. Am J Perinatol 2014; 31: 617628.Google Scholar
Naheed, ZJ, Strasburger, JF, Deal, BJ, Benson, DW Jr, Gidding, SS. Fetal tachycardia: mechanisms and predictors of hydrops fetalis. J Am Coll Cardiol 1996; 27: 17361740.Google Scholar
Schmidt, KG, Ulmer, HE, Silverman, NH, Kleinman, CS, Copel, JA. Perinatal outcome of fetal complete atrioventricular block: a multicenter experience. J Am Coll Cardiol 1991; 17: 13601366.Google Scholar
Lopes, LM, Tavares, GM, Damiano, AP et al. Perinatal outcome of fetal atrioventricular block : one hundred-sixteen cases from a single institution. Circulation 2008; 118: 12681275.Google Scholar
Zhao, H, Cuneo, BF, Strasburger, JF et al. Electrophysiological characteristics of fetal atrioventricular block. J Am Coll Cardiol 2008; 51: 7784.CrossRefGoogle ScholarPubMed
Jaeggi, ET, Hamilton, RM, Silverman, ED, Zamora, SA, Hornberger, LK. Outcome of children with fetal, neonatal or childhood diagnosis of isolated congenital atrioventricular block. A single institution’s 30 year experience. J Am Coll Cardiol 2002; 39: 130137.CrossRefGoogle ScholarPubMed
Ishikawa, S, Yamada, T, Kuwata, T et al. Fetal presentation of long QT syndrome – evaluation of prenatal risk factors: a systematic review. Fetal Diagn Ther 2013; 33: 17.CrossRefGoogle ScholarPubMed
Crotti, L, Tester, DJ, White, WM et al. Long QT syndrome-associated mutations in intrauterine fetal death. JAMA 2013; 309: 14731482.Google Scholar
Cuneo, BF, Ovadia, M, Strasburger, JF et al. Prenatal diagnosis and in utero treatment of torsades de pointes associated with congenital long QT syndrome. Am J Cardiol 2003; 91: 13951398.Google Scholar
Cuneo, BF, Strasburger, JF, Yu, S et al. In utero diagnosis of long QT syndrome by magnetocardiography. Circulation 2013; 128: 21832189.CrossRefGoogle ScholarPubMed
Isaacs, H Jr. Fetal and neonatal cardiac tumors. Pediatr Cardiol 2004; 25: 252273.Google Scholar
Niewiadomska-Jarosik, K, Stańczyk, J, Janiak, K et al. Prenatal diagnosis and follow-up of 23 cases of cardiac tumors. Prenat Diagn 2010; 30: 882887.Google Scholar
Tworetzky, W, McElhinney, DB, Margossian, R, et al Association between cardiac tumors and tuberous sclerosis in the fetus and neonate. Am J Cardiol 2003; 92: 487489.Google Scholar
Gamzu, R, Achiron, R, Hegesh, J, et al. Evaluating the risk of tuberous sclerosis in cases with prenatal diagnosis of cardiac rhabdomyoma. Prenat Diagn 2002; 22: 10441047.CrossRefGoogle ScholarPubMed
Atallah, J, Robertson, M, Rebeyka, IM, Dyck, J, Noga, ML. Antenatal diagnosis and successful surgical removal of a large right ventricular fibroma. Pediatr Cardiol 2006; 27: 493496.Google Scholar
Tseng, JJ, Chou, MM, Lee, YH, Ho, ES. In utero diagnosis of cardiac hemangioma. Ultrasound Obstet Gynecol 1999; 13: 363365.CrossRefGoogle ScholarPubMed
Paladini, D, Tartaglione, A, Vassallo, M, Martinelli, P. Prenatal ultrasonographic findings of a cardiac myxoma. Obstet Gynecol 2003; 102: 11741176.Google Scholar
Pucci, A, Botta, G, Sina, N et al. Life-threatening tumors of the heart in fetal and postnatal age. J Pediatr 2013; 162: 964969.Google Scholar
Rychik, J, Khalek, N, Gaynor, JW et al. Fetal intrapericardial teratoma: natural history and management including successful in utero surgery. Am J Obstet Gynecol 2016; 215: 780.e1780.e7.Google Scholar
Karatza, AA, Wolfenden, JL, Taylor, MJ et al. Influence of twin–twin transfusion syndrome on fetal cardiovascular structure and function: prospective case-control study of 136 monochorionic twin pregnancies. Heart 2002; 88: 271277.Google Scholar
Bahtiyar, MO, Dulay, AT, Weeks, BP, Friedman, AH, Copel, JA. Prevalence of congenital heart defects in monochorionic/diamniotic twin gestations: a systematic literature review. J Ultrasound Med 2007; 26: 14911498.Google Scholar
Nakayama, D, Masuzaki, H, Yoshimura, S, Moriyama, S, Ishimaru, T. Monozygotic twins discordant for single umbilical artery and congenital heart disease. Am J Obstet Gynecol 1998; 179: 256257.CrossRefGoogle ScholarPubMed
Duncan, KR, Denbow, ML, Fisk, NM. The aetiology and management of twin–twin transfusion syndrome. Prenat Diagn 1997; 17: 12271236.Google Scholar
De Paepe, ME, Luks, FI. What-and why-the pathologist should know about twin-to-twin transfusion syndrome. Pediatr Dev Pathol 2013; 16: 237251.Google Scholar
Simpson, LL, Marx, GR, Elkadry, EA, D’Alton, ME. Cardiac dysfunction in twin–twin transfusion syndrome: a prospective, longitudinal study. Obstet Gynecol 1998; 92: 557562.Google Scholar
Lougheed, J, Sinclair, BG, Fung Kee Fung, K et al. Acquired right ventricular outflow tract obstruction in the recipient twin in twin–twin transfusion syndrome. J Am Coll Cardiol 2001; 38: 15331538.Google Scholar
Michelfelder, E, Tan, X, Cnota, J et al. Prevalence, spectrum, and outcome of right ventricular outflow tract abnormalities in twin–twin transfusion syndrome: a large, single-center experience. Congenit Heart Dis 2015; 10: 209218.CrossRefGoogle ScholarPubMed
Oberg, KC, Pestaner, JP, Bielamowicz, L, Hawkins, EP. Renal tubular dysgenesis in twin–twin transfusion syndrome. Pediatr Dev Pathol 1999; 2: 2532.Google Scholar
Spitz, L, Kiely, EM. Conjoined twins. JAMA 2003; 289: 13071310.Google Scholar
Spitz, L, Kiely, EM. Experience in the management of conjoined twins. Br J Surg 2002; 89: 11881192.Google Scholar
Spencer, R. Conjoined Twins. Developmental Malformations and Clinical Implications. Baltimore & London: Johns Hopkins University Press; 2003.Google Scholar
Nichols, BL, Blattner, RJ, Rudolph, AJ. Obstetric management of conjoined twins. Birth Defects 1967; 3: 3851.Google Scholar
Leachman, RD, Latson, JR, Kohler, CM et al Cardiovascular evaluation of conjoined twins. Birth Defects 1967; 3: 5262.Google Scholar
Andrews, RE, McMahon, CJ, Yates, RW et al. Echocardiographic assessment of conjoined twins. Heart 2006; 92: 382387.Google Scholar
Levin, M, Roberts, DJ, Holmes, LB, Tabin, C. Laterality defects in conjoined twins. Nature 1996; 384: 321.CrossRefGoogle ScholarPubMed
Gerlis, LM, Seo, JW, Ho, SY, Chi, JG. Morphology of the cardiovascular system in conjoined twins: spatial and sequential segmental arrangements in 36 cases. Teratology 1993; 47: 91108.Google Scholar
Mian, A, Gabra, NI, Sharma, T et al. Conjoined twins: From conception to separation, a review. Clin Anat 2017; 30: 385396.CrossRefGoogle ScholarPubMed
Frutiger, P. Zum problem der akardie Acta Anat (Basel) 1969; 74: 505531.CrossRefGoogle Scholar
Van Allen, MI, Smith, DW, Shepard, TH. Twin reversed arterial perfusion (TRAP) sequence: a study of 14 twin pregnancies with acardius. Semin Perinatol 1983; 7: 285293.Google ScholarPubMed

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