Book contents
- Manual of Botulinum Toxin Therapy
- Manual of Botulinum Toxin Therapy
- Copyright page
- Dedication
- Contents
- Contributors
- Preface for the Third Edition
- Chapter 1 The Pretherapeutic History of Botulinum Neurotoxin
- Chapter 2 Botulinum Neurotoxin
- Chapter 3 Pharmacology of Botulinum Toxin Therapy
- Chapter 4 Immunological Properties of Botulinum Neurotoxins
- Chapter 5 Examination and Treatment of Complex Cervical Dystonia
- Chapter 6 Visualization of Ultrasound-Guided Intramuscular Injections in Muscles Relevant for Cervical Dystonia
- Chapter 7 Ultrasound Guidance for Botulinum Neurotoxin Therapy
- Chapter 8 Treatment of Cervical Dystonia
- Chapter 9 Treatment of Blepharospasm
- Chapter 10 Botulinum Neurotoxin in Oromandibular Dystonia
- Chapter 11 Botulinum Neurotoxin Therapy of Laryngeal Muscle Hyperactivity Syndromes
- Chapter 12 The Use of Botulinum Neurotoxin in Otorhinolaryngology
- Chapter 13 Treatment of Hemifacial Spasm with Botulinum Toxin
- Chapter 14 Botulinum Toxin in Treatment of Tics
- Chapter 15 The Use of Botulinum Toxin in Tremors
- Chapter 16 The Role of Ultrasound for Botulinum Neurotoxin Injection in childhood Spasticity
- Chapter 17 The Use of Botulinum Neurotoxin in Spastic Infantile Cerebral Palsy
- Chapter 18 The Use of Botulinum Neurotoxin in Spasticity Using Ultrasound Guidance
- Chapter 19 The Use of Botulinum Toxin in Spasticity
- Chapter 20 Treatment of Stiff-Person Syndrome with Botulinum Toxin
- Chapter 21 Botulinum Toxin in Ophthalmology
- Chapter 22 Cosmetic Uses of Botulinum Neurotoxins for the Upper Face
- Chapter 23 Botulinum Toxin for the Lower Face
- Chapter 24 Botulinum Toxin in the Treatment of Gummy Smile
- Chapter 25 Botulinum Toxin for the Breast
- Chapter 26 Treatment of Depression with Botulinum Toxin
- Chapter 27 Hyperhidrosis
- Chapter 28 Botulinum Toxin in the Treatment for Ischemic Digits and Chronic Pain
- Chapter 29 Botulinum Toxin in Wound Healing
- Chapter 30 Use of Botulinum Neurotoxin in Neuropathic Pain
- Chapter 31 The Use of Botulinum Toxin in the Management of Headache Disorders
- Chapter 32 Use of Botulinum Toxin in Musculoskeletal Pain and Arthritis
- Chapter 33 Treatment of Plantar Fasciitis/Plantar Fasciopathy with Botulinum Neurotoxins
- Chapter 34 Use of Botulinum Toxin in the Treatment of Low Back Pain
- Chapter 35 Use of Botulinum Neurotoxin in the Treatment of Piriformis Syndrome
- Chapter 36 Ultrasound-Guided Botulinum Toxin Injections for Thoracic Outlet Syndrome
- Chapter 37 Botulinum Neurotoxin in the Gastrointestinal Tract
- Chapter 38 Botulinum Neurotoxin Applications in Urological Disorders
- Chapter 39 Treatment of Focal Hand Dystonia
- Index
- References
Chapter 3 - Pharmacology of Botulinum Toxin Therapy
Published online by Cambridge University Press: 02 November 2023
- Manual of Botulinum Toxin Therapy
- Manual of Botulinum Toxin Therapy
- Copyright page
- Dedication
- Contents
- Contributors
- Preface for the Third Edition
- Chapter 1 The Pretherapeutic History of Botulinum Neurotoxin
- Chapter 2 Botulinum Neurotoxin
- Chapter 3 Pharmacology of Botulinum Toxin Therapy
- Chapter 4 Immunological Properties of Botulinum Neurotoxins
- Chapter 5 Examination and Treatment of Complex Cervical Dystonia
- Chapter 6 Visualization of Ultrasound-Guided Intramuscular Injections in Muscles Relevant for Cervical Dystonia
- Chapter 7 Ultrasound Guidance for Botulinum Neurotoxin Therapy
- Chapter 8 Treatment of Cervical Dystonia
- Chapter 9 Treatment of Blepharospasm
- Chapter 10 Botulinum Neurotoxin in Oromandibular Dystonia
- Chapter 11 Botulinum Neurotoxin Therapy of Laryngeal Muscle Hyperactivity Syndromes
- Chapter 12 The Use of Botulinum Neurotoxin in Otorhinolaryngology
- Chapter 13 Treatment of Hemifacial Spasm with Botulinum Toxin
- Chapter 14 Botulinum Toxin in Treatment of Tics
- Chapter 15 The Use of Botulinum Toxin in Tremors
- Chapter 16 The Role of Ultrasound for Botulinum Neurotoxin Injection in childhood Spasticity
- Chapter 17 The Use of Botulinum Neurotoxin in Spastic Infantile Cerebral Palsy
- Chapter 18 The Use of Botulinum Neurotoxin in Spasticity Using Ultrasound Guidance
- Chapter 19 The Use of Botulinum Toxin in Spasticity
- Chapter 20 Treatment of Stiff-Person Syndrome with Botulinum Toxin
- Chapter 21 Botulinum Toxin in Ophthalmology
- Chapter 22 Cosmetic Uses of Botulinum Neurotoxins for the Upper Face
- Chapter 23 Botulinum Toxin for the Lower Face
- Chapter 24 Botulinum Toxin in the Treatment of Gummy Smile
- Chapter 25 Botulinum Toxin for the Breast
- Chapter 26 Treatment of Depression with Botulinum Toxin
- Chapter 27 Hyperhidrosis
- Chapter 28 Botulinum Toxin in the Treatment for Ischemic Digits and Chronic Pain
- Chapter 29 Botulinum Toxin in Wound Healing
- Chapter 30 Use of Botulinum Neurotoxin in Neuropathic Pain
- Chapter 31 The Use of Botulinum Toxin in the Management of Headache Disorders
- Chapter 32 Use of Botulinum Toxin in Musculoskeletal Pain and Arthritis
- Chapter 33 Treatment of Plantar Fasciitis/Plantar Fasciopathy with Botulinum Neurotoxins
- Chapter 34 Use of Botulinum Toxin in the Treatment of Low Back Pain
- Chapter 35 Use of Botulinum Neurotoxin in the Treatment of Piriformis Syndrome
- Chapter 36 Ultrasound-Guided Botulinum Toxin Injections for Thoracic Outlet Syndrome
- Chapter 37 Botulinum Neurotoxin in the Gastrointestinal Tract
- Chapter 38 Botulinum Neurotoxin Applications in Urological Disorders
- Chapter 39 Treatment of Focal Hand Dystonia
- Index
- References
Summary
Botulinum neurotoxins (BoNTs) are protins derived from the bacterium Clostridium botulinum. Nine serotypes are known; seroptypes A and B have been formulated for clinical use. BoNTs cleave one of the three soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNARE) proteins: vesicle-associated membrane protein (VAMP), synaptosomal-associated protein 25 (SNAP-25), or syntaxin. Upon entry into the synaptic terminal, BoNT inhibits the exocytosis of neurotransmitter containing synaptic vesicles. Cliical effects begin developing within a week after injection into skeletal muscle, then wear off after 2–4 months, requiring repeat injection. Neutralizing antibodies may develop, reducing clinical effects. Newer toxin preparations under development are listed in a table.
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- Manual of Botulinum Toxin Therapy , pp. 13 - 17Publisher: Cambridge University PressPrint publication year: 2023