This chapter summarizes available findings on the neuroendocrine effects of exposure to trauma during early development, with a focus on a role for such alterations in the increased risk of mood and anxiety disorders in adulthood. The principal components of the stress system are the hypothalamic-pituitary-adrenal (HPA) axis, the locus ceruleus-norepinephrine (LC-NE) system and the extrahypothalamic corticotropin-releasing factor (CRF) systems. In addition, increased rates of major depression, post-traumatic stress disorder (PTSD) and attention-deficit hyperactivity disorder (ADHD) have been reported in maltreated children. The relationship between early adverse experiences and the development of adult psychopathology is likely mediated by alterations in neurobiological systems involved in the regulation of stress. Findings from the research would have important implications for the development of optimized treatment strategies that directly target different neurobiological pathways involved in depression and anxiety disorders in victims of early child maltreatment.