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Chapter 26 - Endocrinology and Diabetes in the Elder

Published online by Cambridge University Press:  11 July 2020

By
David Levy
Edited by
Kim A. Collins  and
Roger W. Byard
Kim A. Collins
Affiliation:
LifePoint Inc, South Carolina
Roger W. Byard
Affiliation:
University of Adelaide
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Summary

Endocrine conditions and diabetes (with the exception of type 2 diabetes) are associated in the minds of physicians with the early part of life: many thyroid disorders, especially primary hypothyroidism and Graves’ disease, present in people in their teens, 20s, and 30s. Pituitary tumors have usually been diagnosed in younger people, as a cardinal presenting symptom is menstrual abnormalities, especially amenorrhea.

Type
Chapter
Information
Geriatric Forensic Medicine and Pathology , pp. 469 - 485
Publisher: Cambridge University Press
Print publication year: 2020

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References

Tábak, AG, Jokela, M, Akbaraly, TN et al. Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study. Lancet 2009; 373: 2215–2212.Google Scholar
van den Beld, KW, Kaufman, JM, Zillikens, MC et al. The physiology of endocrine systems with ageing. Lancet Diabetes Endocrinol 2018; 6: 657–658.CrossRefGoogle ScholarPubMed
Junnila, RK, List, EO, Berryman, DE, Murrey, JW, Kopchick, JJ. The GH/IGF-1 axis in ageing and longevity. Nat Rev Endocrinol 2013; 9: 366–376.Google Scholar
Ní Chróínín, D, Lambert, J. Sudden headache, third nerve palsy and visual deficit: thinking outside the subarachnoid haemorrhage box. Age Aging 2013; 42: 810–812.Google Scholar
Murad-Kejbou, S, Eggenberger, E. Pituitary apoplexy: evaluation, management, and prognosis. Curr Opin Ophthalmol 2009; 20: 456–461.Google Scholar
Sun, T, Liu, L, Sunnassee, A, Zhuo, L, Zhu, S. Sudden death in custody due to pituitary apoplexy during long restriction in a sitting position: a case report and review of the literature. J Forensic Leg Med 2013; 20: 812–815.Google Scholar
David, NJ. Pituitary apoplexy goes to the bar: litigation for delayed diagnosis, deficient vision, and death. J Neuroophthalmol 2006; 26: 128–133.Google Scholar
Warwar, RE, Bhullar, SS, Pestring, RJ, Fadell, RJ. Sudden death from pituitary apoplexy in a patient presenting with an isolated sixth cranial nerve palsy. J Neuroophthalmol 2006; 26: 95–97.Google Scholar
LaPorte, M, Pollock, J, Ward, M, Fulcher, J. An unusual presentation of pituitary gland apoplexy with non-infectious meningitis. Am J Forensic Med Pathol 2018; 39: 23–26.Google Scholar
Rajasekaran, S, Vanderpump, M, Baldeweg, S et al. UK guidelines for the management of pituitary apoplexy. Clin Endocrinol (Oxf) 2011; 74: 9–20.Google Scholar
Chang, LS, Barroso-Sousa, R, Tolaney, SM, et al. Endocrine toxicity of cancer chemotherapy targeting immune checkpoints. Endocrinol Rev 2019; 40: 17–65.CrossRefGoogle Scholar
Dalakas, MC. Neurological complications of immune checkpoint inhibitors: what happens when you ‘take the brakes off’ the immune system. Ther Adv Neurol Disord 2018. Epub ahead of print. PMID:30245744Google Scholar
Chang, LS, Barroso-Sousa, R, Tolaney, SM et al. Endocrine toxicity of cancer immunotherapy targeting immune checkpoints. Endocr Rev 2019; 40: 17–65.Google Scholar
Hryniewicki, AT, Wang, C, Shatsky, RA, Coyne, CJ. Management of immune checkpoint inhibitor toxicities: a review and clinical guideline for emergency physicians. J Emerg Med 2018; 55: 489–502.Google Scholar
Caturegli, P, Newschaffer, C, Olivi, A, et al. Autoimmune hypophysitis. Endocr Rev 2005; 26: 599–614.Google Scholar
Burman, P, Mattson, AF, Johannson, G et al. Deaths among adult patients with hypopituitarism: hypocortisolism during acute stress, and de novo malignant brain tumours contribute to an increased mortality. J Clin Endocrinol Metab 2013; 98: 1466–1475.Google Scholar
Javanbakht, A, D’Apuzzo, M, Badie, B, Salehian, B. Pituitary metastasis: a rare condition. Endocr Connect August 23, 2018. Epub ahead of print. doi:10.1530/EC-18-0338.Google Scholar
Curtó, L, Trimarchi, F. Hypopituitarism in the elderly: a narrative review on clinical management of hypothalamic-pituitary-gonadal, hypothalamic-pituitary-thyroid and hypothalamic-pituitary-adrenal axes dysfunction. J Endocrinol Invest 2016; 39: 1115–1124.Google Scholar
Ishii, M. Endocrine emergencies with neurologic manifestations. Continuum (Minneap Minn) 2017; 23 (3 Neurology of Systemic Disease): 778–801.Google Scholar
Palmiere, C, Bardy, D, Letovanec, I, et al. Biochemical markers of fatal hypothermia. Forensic Sci Int 2013; 226: 54–61.Google Scholar
Lynch, MJ, Woodford, NW. Sudden unexpected death in the setting of undiagnosed Graves’ disease. Forensic Sci Med Pathol 2014; 10: 452–456.Google Scholar
Quinkler, M, Ekman, B, Zhang, P, Isidori, AM, Murray, RD; EU-AIR Investigators. Mortality data from the European Adrenal Insufficiency Registry – patient characterization and associations. Clin Endocrinol (Oxf) 2018; 89: 30–35.Google Scholar
Hahner, S, Spinnler, C, Fassnacht, M et al. High incidence of adrenal crisis in educated patients with chronic adrenal insufficiency: a prospective study. J Clin Endocrinol Metab 2015; 100: 407–416.Google Scholar
Clapper, A, Nashelsky, M, Dailey, M. Evaluation of serum cortisol in the post-mortem diagnosis of acute adrenal insufficiency. Am J Forensic Med Pathol 2008; 29: 181–184.Google Scholar
Sajadeh, A, Binici, Z, Mouridsen, MR et al. Mild hyponatraemia carries a poor prognosis in community subjects. Am J Med 2009; 122: 679–686.CrossRefGoogle Scholar
Liamis, G, Rodenburg, EM, Hofman, A et al. Electrolyte disorders in community subjects: prevalence and risk factors. Am J Med 2013; 126: 256–263.Google Scholar
Diederich, S, Franen, NF Bähr, V, Oelkers, W. Severe hyponatraemia due to hypopituitarism with adrenal insufficiency: report on 28 cases. Eur J Endocrinol 2003; 148: 609–617.Google Scholar
Jönsson, AK, Lövborg, H, Lohr, W, Ekman, B, Rocklöv, J. Increased risk of drug-induced hyponatremia during high temperatures. Int J Environ Res Public Health 2017; 14: E827.CrossRefGoogle ScholarPubMed
Bain, SC, Gill, GV, Dyer, PH et al. Characteristics of Type 1 diabetes of over 50 years duration (the Golden Years Cohort). Diabet Med 2003; 20: 808–811.Google Scholar
Sun, JK, Keenan, HA, Cavallerano, JD et al. Protection from retinopathy and other complications in patients with type 1 diabetes of extreme duration: the Joslin 50-year medalist study. Diabetes Care 2011; 34: 968–974.CrossRefGoogle ScholarPubMed
Beck, RW, Tamborlane, WV, Bergenstal, RM et al.; The T1D Exchange Clinic Network. The T1D Exchange clinic registry. J Clin Endocrinol Metab 2012; 97: 4383–4389.CrossRefGoogle ScholarPubMed
Vuk, A, Baretic, M, Osvatic, MM et al. Treatment of diabetic ketoacidosis associated with antipsychotic medication: literature review. J Clin Psychopharmacol 2017; 37: 584–589.Google Scholar
Levy, D. Psychological aspects of diabetes. In Practical Diabetes Care, 4th ed. Oxford, Wiley-Blackwell, 2018: Chapter 15.Google Scholar
Löfman, S, Hakko, H, Mainio, A. Timonen, M, Räsänen, P. Characteristics of suicide among diabetes patients: a population based study of suicide victims in Northern Finland. J Psychosom Res 2012; 73: 268–271.CrossRefGoogle ScholarPubMed
Tattersall, RB, Gill, GV. Unexplained deaths of type 1 diabetic patients. Diabet Med 1991; 8: 49–58.Google Scholar
Tu, E, Twigg, SM, Duflou, J, Semsarian, C. Causes of death in young Australians with type 1 diabetes: a review of coronial postmortem examinations. Med J Aust 2008; 188: 699–702.Google Scholar
Luna, J, Gilliland, MG, Kewan-Lowe, KO, Tanenberg, RJ. Postmortem diagnosis of diabetic ketoacidosis presenting as the “dead in bed syndrome.” Endocr Pract 2014; 20: e123–125.Google Scholar
Lee, AS, Brooks, BA, Simmons, L et al. Hypoglycaemia and QT interval prolongation: detection by simultaneous Holter and continuous glucose monitoring. Diabetes Res Clin Pract 2016; 113: 211–214.Google Scholar
Benbow, SJ, Walsh, A, Gill, GV. Brittle diabetes in the elderly. J R Soc Med 2001; 94: 578–580.Google Scholar
Misra-Herbert, AD, Pantalone, KM, Ji, X et al. Patient characteristics associated with severe hypoglycemia in a type 2 diabetes cohort in a large, integrated health care system from 2006 to 2015. Diabetes Care 2018; 41: 1164–1171.Google Scholar
Simpson, SH, Lee, J, Choi, S et al. Mortality risk among sulfonylureas: a systematic review and network meta-analysis. Lancet Diabetes Endocrinol 2015; 3: 43–51.Google Scholar
Corley, BT, Davenport, C, Delaney, L, Hatunic, M, Smith, D. Hypoglycaemia-induced myocardial infarction as a result of sulphonylurea misuse. Diabet Med 2011; 28: 876–879.Google Scholar
Marks, V. Murder by insulin: suspected, purported and proven – a review. Drug Test Anal 2009; 1: 162–176.Google Scholar
Fralick, M, Schneeweiss, S, Patorno, E. Risk of diabetic ketoacidosis after initiation of an SGLT2 inhibitor. N Engl J Med 2017; 376: 2300–2302.Google Scholar
Mühlhauser, I, Sawicki, PT, Blank, M et al. Reliability of causes of death in persons with Type 1 diabetes. Diabetologia 2002; 45: 1490–1497.Google Scholar
Ali, Z, Levine, B, Ripple, M, Fowler, DR. Diabetic ketoacidosis: a silent death. Am J Forensic Med Pathol 2012; 33: 189–193.Google Scholar
Hockenhull, J, Dhillo, W, Andrews, R, Paterson, S. Investigations of markers to indicate and distinguish death due to alcoholic ketoacidosis, diabetic ketoacidosis and hyperosmolar hyperglycemic state using post-mortem samples. Forensic Sci 2012; 214: 142–147.Google Scholar
Kodikara, S, Paranitharan, P, Pollanen, MS. The role of the Armanni-Ebstein lesion, hepatic steatosis, biochemical analysis and second generation and-psychotic drugs in fatal diabetic ketoacidosis. J Forensic Leg Med 2013; 20: 108–111.Google Scholar
Chang, LH, Guo, YW, Chen, HS. Hyperglycemic hyperosmolar status is associated with subsequent all-cause mortality in elderly adults with type 2 diabetes mellitus. J Am Geriatr Soc 2016; 64: e218–e219.Google Scholar
Lipscombe, LL, Austin, PC, Alessi-Severini, S et al.; Canadian Network for Observational Drug Effects Studies (CNODES) Investigators. Atypical antipsychotics and hyperglycemic emergencies: multicentre, retrospective cohort study of administrative data. Schizophr Res 2014; 154: 54–60.Google Scholar
Secrest, AM, Prince, CT, Costacou, T, Miler, RG, Orchard, TJ. Predictors of and survival after incident stroke in type 1 diabetes. Diab Vasc Dis Res 2013; 10: 3–10.Google Scholar
Gregg, EW, Li, Y, Wang, J et al. Changes in diabetes-related complications in the United States, 1990–2010. N Engl J Med 2014; 370: 1514–1523.Google Scholar
Read, SH, McAllister, DA, Colhoun, HM et al.; Scottish Diabetes Research Network Epidemiology Group. Incident ischaemic stroke and type 2 diabetes: trends in incidence and case fatality in Scotland 2004–2013. Diabet Med 2018; 35: 99–106.Google Scholar
Zaccardi, F, Khan, H, Laukkanen, JA. Diabetes mellitus and risk of sudden cardiac death: a systematic review and meta-analysis. Int J Cardiol 2014; 177: 535–537.CrossRefGoogle ScholarPubMed
Sharma, A, Green, JB, Dunning, A et al.; TECOS Study Group. Causes of death in a contemporary cohort of patients with type 2 diabetes and atherosclerotic cardiovascular disease: insights from the TECOS Trial. Diabetes Care 2017; 40: 1763–1770.CrossRefGoogle Scholar
Reinier, K, Marijon, E, Uy-Evanado, A et al. The association between atrial fibrillation and sudden cardiac death: the relevance of heart failure. JACC Heart Fail 2014; 2: 221–227.Google Scholar
Levy, D. Practical Diabetes Care, 4th ed. Oxford, Wiley-Blackwell, 2018.Google Scholar
Slater, DN, Smith, GT, Mundy, K. Diabetes mellitus with ketoacidosis presenting as Fournier’s gangrene. J R Soc Med 1982; 75: 530–532.Google Scholar
Majdoub, W, Mosbahi, A, Bonbled, F. Sudden unexpected death due to Fournier gangrene. Forensic Sci Med Pathol 2019; 15: 155–158.Google Scholar
Soong, TR, Granter, SR, Hefner, HK, Laga, AC. Infectious disorders of the female genital tract. In Crum, CP, Nucci, MR (eds.) Diagnostic Gynecologic and Obstetric Pathology, 3rd ed. Philadelphia, Elsevier, 2018.Google Scholar

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