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Chapter 14 - Fetal Infections

Published online by Cambridge University Press:  08 June 2023

Zarko Alfirevic
Affiliation:
Liverpool Women's Hospital
Seshadri Suresh
Affiliation:
Mediscan, Chennai
Jonathan Hyett
Affiliation:
Prince Alfred Hospital, Sydney
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Summary

This chapter describes clinical presentation, interpretation of maternal serology, management and counselling for the following infections: cytomegalovirus, parvovirus B19, varicella zoster, rubella, measles, Zika, toxoplasmosis and syphilis.

Type
Chapter
Information
Fetal Medicine
An Illustrated Textbook
, pp. 357 - 380
Publisher: Cambridge University Press
Print publication year: 2023

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References

Primary Sources

Buca, D, Di Mascio, D, Rizzo, G, et al. Outcome of fetuses with congenital cytomegalovirus infection: a systematic review and meta-analysis. Ultrasound Obstet Gynecol 2020;57:551559.CrossRefGoogle Scholar
RCOG. Congenital cytomegalovirus infection: update on treatment: scientific impact paper No. 56. BJOG 2018;125:e1e11.Google Scholar
Shahar-Nissan, K, Pardo, J, Peled, O, et al. Valaciclovir to prevent vertical transmission of cytomegalovirus after maternal primary infection during pregnancy: a randomised, double-blind, placebo-controlled trial. Lancet 2020;396(10253):779785.CrossRefGoogle ScholarPubMed

Secondary Sources

Bascietto, F, Liberati, M, Murgano, D, et al. Outcome of fetuses with congenital parvovirus B19 infection: systematic review and meta-analysis. Ultrasound Obstet Gynecol 2018;52:569576.CrossRefGoogle ScholarPubMed
Dembinski, J, Haverkamp, F, Maara, H, et al. Neurodevelopmental outcome after intrauterine red cell transfusion for parvovirus B19-induced fetal hydrops. BJOG 2002;109(11):12321234.Google ScholarPubMed
Dijkmans, AC, de Jong, EP, Dijkmans, BAC, et al. Parvovirus B19 in pregnancy: prenatal diagnosis and management of fetal complications. Curr Opin Obstet Gynecol 2012;24:95101.CrossRefGoogle ScholarPubMed
Zavattoni, M, Paolucci, S, Sarasini, A, et al. Diagnostic and prognostic value of molecular and serological investigation of human parvovirus B19 infection during pregnancy. New Microbiologica 2016;39:181185.Google ScholarPubMed
Bouthry, E, Picone, O, Hamdi, G, et al. Rubella and pregnancy: diagnosis, management and outcomes. Prenat Diagn 2014;34:12461253.CrossRefGoogle ScholarPubMed
Yazigi, A, De Pecoulas, AE, Vauloup-Fellous, C, et al. Fetal and neonatal abnormalities due to congenital rubella syndrome: a review of literature. J Matern Fetal Neonatal Med 2017;30:274278.CrossRefGoogle ScholarPubMed
Congera, P, Maraolo, AE, Parente, S, et al. Measles in pregnant women: a systematic review of clinical outcomes and a meta-analysis of antibodies seroprevalence. J Infect 2020;80(2):152160.CrossRefGoogle Scholar
Viens, LJ, Fleck-Derderian, S, Baez-Santiago, MA, et al. Role of prenatal ultrasonography and amniocentesis in the diagnosis of congenital Zika syndrome. Obstet Gynecol 2020;135:11851197.CrossRefGoogle ScholarPubMed
Australasian Society for Infectious Diseases. Toxoplasmosis Gondii. In Management of Perinatal Infections (Palasanthiran, P, Starr, M, Jones, C, Giles, M, eds). Australasian Society for Infectious Diseases, Sydney, 2014; 6974.Google Scholar
Azevedo, C, Brasil, P, Guida, L, Moreira, ME. Performance of polymerase chain reaction analysis of the amniocytic fluid of pregnant women for the diagnosis of congenital toxoplasmosis: a systematic review and meta-analysis. PLoS One 2016;11:e1049938.Google Scholar
Berrébi, A, Assouline, C, Bessières, M-H, et al. Long-term outcome of children with congenital toxoplasmosis. Am J Obstet Gynecol 2010;203:552.e16.CrossRefGoogle ScholarPubMed
CNGO. Toxoplasmosis screening during pregnancy in France: opinion of an expert panel for the CNGO. J Gynecol Obstet Hum Reprod 2020;49:101814.CrossRefGoogle Scholar
Codaccioni, C, Picone, O, Lambert, V et al. Ultrasound features of fetal toxoplasmosis: a contemporary survey in 88 fetuses. Prenat Diagn 2020;40:17411752.CrossRefGoogle Scholar
Mandelbrot, L, Keffer, F, Sitta, R, et al. Prenatal therapy with pyrimethamine and sulfadiazine versus spiramycin to reduce placental transmission of toxoplasmosis: a multicentre, randomised trial. Am J Obstet Gynecol 2018;219:386.e1386.e9.CrossRefGoogle Scholar
Adhikari, EH. Syphilis in pregnancy. Obstet Gynecol 2020;135:11211135.CrossRefGoogle ScholarPubMed
Lin, JS, Eder, ML, Bean, SI. Screening for syphilis infection in pregnant women: updated evidence report and systematic review for the US Preventive Services Task Force. JAMA 2018;320(9):918925.CrossRefGoogle ScholarPubMed
Public Health England. (2015). Syphilis Serology: UK Standards for Microbiology Investigations. www.gov.uk/uk-standards-for-microbiologyinvestigations-smi-quality-and-consistency-in-clinical-laboratoriesGoogle Scholar
Rac, MW, Bryant, SN, McIntire, DD, et al. Progression of ultrasound findings of fetal syphilis after maternal treatment. Am J Obstet Gynecol 2014;211(4):426.e1426.e6.CrossRefGoogle ScholarPubMed

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