Mary Darly has been called the mother of British caricature, a pioneer who – with her husband Matthias – paved the way for the ‘golden age’ of satirical prints. This chapter reveals new details of her life and her twenty-four-year career gleaned largely from study of the Darly prints and newspaper advertisements. Mary saw the importance of prints in influencing political affairs: she produced satires before her marriage in 1759 as well as after her husband’s death in 1780, and she published some of the most virulent prints in the campaign against prime minister Lord Bute in 1762–1763. Appealing to the new fashion for images that exaggerated facial features, in 1762 she published the first how-to book in English, The Principles of Caricatura Drawing. The Darlys produced a wide range of prints but their greatest success came in the 1770s with a series of caricatures of well-known people described as ‘Macaronies’. Designs were provided by enthusiastic amateurs and people flocked to the Darly shop near Charing Cross for their annual exhibitions – the first commercial print shows in London.