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Chapter 34 - Systemic Lupus Erythematosus and Pregnancy

from Section 4 - Maternal Medicine

Published online by Cambridge University Press:  20 November 2021

By
Sarah McRobbie  and
Katrina Shearer
Edited by
Tahir Mahmood ,
Charles Savona Ventura ,
Ioannis Messinis  and
Sambit Mukhopadhyay
Tahir Mahmood
Affiliation:
Victoria Hospital, Kirkcaldy
Charles Savona Ventura
Affiliation:
University of Malta, Malta
Ioannis Messinis
Affiliation:
University of Thessaly, Greece
Sambit Mukhopadhyay
Affiliation:
Norfolk & Norwich University Hospital, UK
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Summary

Systemic lupus erythematosus (SLE) is a chronic multi-organ inflammatory disease which can involve any organ or system. It is an autoimmune condition with an overproduction of autoantibodies directed against various nuclear components and cell-surface antigens. The underlying cause of the condition is unknown, but it is likely multifactorial with genetic and environmental factors having a role. The incidence is higher in women than in men; some sources quote this as high as 9:1, and is even higher during the reproductive years [1, 2].

Type
Chapter
Information
The EBCOG Postgraduate Textbook of Obstetrics & Gynaecology
Obstetrics & Maternal-Fetal Medicine
 , pp. 287 - 294
Publisher: Cambridge University Press
Print publication year: 2021

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References

Suggested Reading

Cauldwell, M, Nelson-Piercy, C. Maternal and fetal complications of systemic lupus erythematosus. Obstet Gynaecol. 2012;14:167–74.Google Scholar
LUPUS UK. www.lupusuk.org.uk/lupus-and-pregnancy/Google Scholar
Recommended for patient information. [accessed online 6th December 2019]Google Scholar
RCOG online StratOG learning resource: Connective tissue, bone and joint disorders tutorial.Google Scholar
Lateef, A, Petri, M. Managing lupus patients during pregnancy. Best Pract Res Clin Rheumatol. 2013;27(3):435–47. doi: 10.1016/j.berh.2013.07.005CrossRefGoogle ScholarPubMed

References

Cauldwell, M, Nelson-Piercy, C. Maternal and fetal complications of systemic lupus erythematosus. Obstet Gynaecol. 2012;14:167–74.Google Scholar
Nelson-Piercy, C, ed. Chapter 8. In Handbook of Obstetric Medicine, 4th ed. London: Informa Healthcare;2010.CrossRefGoogle Scholar
Lateef, A, Petri, M. Managing lupus patients during pregnancy. Best Pract Res Clin Rheumatol. 2013;27(3):435–47. doi: 10.1016/j.berh.2013.07.0057Google Scholar
Andreoli, L, Bertsias, GK, Agmon-Levin, N, et al. EULAR recommendations for women’s health and the management of family planning, assisted reproduction, pregnancy and menopause in patients with systemic lupus erythematosus and/or antiphospholipid syndrome. Ann Rheum Dis. 2017;76:476–85.Google Scholar
Gladman, DD, Urowitz, MB, Esdaile, , et al. Guidelines for referral and management of systemic lupus erythematosus in adults. Arthritis Rheum. 1999;42(9):1785–96.Google Scholar
American College of Rheumatology. ACR‐endorsed criteria for rheumatic diseases. www.rheumatology.org/Practice-Quality/Clinical-Support/Criteria/ACR-Endorsed-Criteria [accessed online 11th Dec 2019]Google Scholar
Grygiel-Górniak, B, Rogacka, N, Puszczewicz, M. Antinuclear antibodies in healthy people and non-rheumatic diseases – diagnostic and clinical implications. Reumatologia. 2018;56(4),243–8. doi: 10.5114/reum.2018.77976CrossRefGoogle ScholarPubMed
Gordon, C, Amissah-Arthur, MB, Gayed, M, et al., for the British Society for Rheumatology Standards, Audit and Guidelines Working Group. The British Society for Rheumatology guideline for the management of systemic lupus erythematosus in adults. Rheumatology. 2018;57(1):e1–e45, https://doi.org/10.1093/rheumatology/kex286Google Scholar
National Institute for Health and Care Excellence. (2019) Hypertension in pregnancy: diagnosis and management (NICE Guideline 133).Google Scholar
Levy, RA, Vilela, VS, Cataldo, MJ, et al. Hydroxychloroquine (HCQ) in lupus pregnancy: double-blind and placebo-controlled study. Lupus. 2001;10:401–4.CrossRefGoogle ScholarPubMed
Nelson-Piercy, C, ed. Section B, Differential diagnosis of medical problems in pregnancy – Proteinuria. In Handbook of Obstetric Medicine, 4th ed. London: Informa Healthcare; 2010. p. 294.Google Scholar
Kapur, A, Dey, M, Tangri, M, Bandhu, HC. Maternal anti-Ro/SSA and anti-La/SSB antibodies and fetal congenital heart block. J Obstet Gynaecol India.2015;65(3):193–95. doi: 10.1007/s13224-014-0608-2Google Scholar

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