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Chapter 9 - Acute Myeloid Leukaemia

Published online by Cambridge University Press:  12 November 2020

Jon van der Walt ,
Attilio Orazi  and
Daniel A. Arber
By
Kaaren Reichard  and
Daniel A Arber
Jon van der Walt
Affiliation:
St Thomas’ Hospital, London
Attilio Orazi
Affiliation:
Texas Tech University
Daniel A. Arber
Affiliation:
University of Chicago
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Summary

Acute myeloid leukaemia (AML) is a highly complex and heterogeneous disease. Proper classification according to the 2016 World Health Organization (WHO) classification requires a systematic approach and integration of key clinical, laboratory, pathologic and genetic information [1, 2]. Great advances in our understanding of the pathogenesis and molecular underpinnings of AML have been realized since the original AML classification using the French–American–British (FAB) system (1976). This genetic revolution not only contributes to enhanced disease diagnosis and prognostication but also to ongoing improvements in therapeutic strategies.

Keywords

Acute leukemaimyeloidclassificationdiagnosismyelodysplasia-relatedtherapy-relatedsarcoma
Type
Chapter
Information
Diagnostic Bone Marrow Haematopathology , pp. 127 - 145
Publisher: Cambridge University Press
Print publication year: 2021

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