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Introduction

Published online by Cambridge University Press:  22 February 2019

Jeff Victoroff
Affiliation:
University of Southern California, Torrance
Erin D. Bigler
Affiliation:
Brigham Young University, Utah
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Summary

Concussive brain injuries have surely been observed by hominins since long before the dawn of humankind. Medical accounts go back at least 2,000 years. However: (1) no definition for this condition has achieved universal acceptance; (2) the pathophysiology is poorly understood; (3) the frequency with which various outcomes can be expected is highly controversial; and (4) the research funding seems disproportionately exiguous in the light of this disorder's probable global impact. This textbook is the first of a new era, informed by paradigm shifts unveiled by empirical discoveries and conceptual insights over the last two decades.
Type
Chapter
Information
Concussion and Traumatic Encephalopathy
Causes, Diagnosis and Management
, pp. 1 - 32
Publisher: Cambridge University Press
Print publication year: 2019

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References

Zhang, K, Johnson, B, Pennell, D, Ray, W, Sebastianelli, W, Slobounov, S. Are functional deficits in concussed individuals consistent with white matter structural alterations: Combined FMRI and DTI study. Exp Brain Res 2010;20:5770.Google Scholar
Lidvall, HF, Linderoth, B, Norlin, B. Causes of the post-concussional syndrome. Acta Neurol Scand Suppl 1974;56:3144.Google Scholar
Barnes, DE, Kaup, A, Kirby, KA, Byers, AL, Diaz-Arrastia, R, Yaffe, K. Traumatic brain injury and risk of dementia in older veterans. Neurology 2014;83:312319.CrossRefGoogle ScholarPubMed
National Institute of Health. National Institute of Neurological Disorders and Stroke. Report on the brain trauma-related neurodegeneration: Strategies to define, detect, and predict workshop. July 22–23, 2013. Available at www.ninds.nih.gov/news_and_events/proceedings/TBI-related_neurodegeneration_workshop_report.htm.Google Scholar
Walker, AE, Caveness, WF, Critchley, M, editors. Late effects of head injury. Springfield, IL: Charles C. Thomas, 1969.Google Scholar
Teuber, H-L. Neglected aspects of the posttraumatic syndrome. In Walker, AE, Caveness, WF, Critchley, M, editors. Late effects of head injury. Springfield, IL: Charles C. Thomas, 1969, pp. 1334.Google Scholar
Koch, W, Filehne, W. Beiträge zur experimentellen Chirurgie. Über die Commotio cerebri. Arch Klin Chir 1874;17: 190231.Google Scholar
Osnato, M, Giliberti, V. Postconcussion neurosis-traumatic encephalitis: A conception of postconcussion phenomena. Arch Neurol Psychiatr 1927;18:181214.Google Scholar
Martland, HS. Punch drunk. JAMA 1928;91:11031107.Google Scholar
Courville, CB. Commotio cerebri: Cerebral concussion and the postconcussion syndrome in their medical and legal aspect. Los Angeles: San Lucas Press, 1953.Google Scholar
European Commission. The international initiative for traumatic brain injury research (InTBIR). 2014. Available at http://ec.europa.eu/research/health/medical-research/brain-research/international-initiative_en.html.Google Scholar
The changing landscape of traumatic brain injury research. Lancet Neurol 2012;8:651.Google Scholar
Kazakoff, L. NFL player’s suicide opens discussion on traumatic brain injury. 2011. Available at http://blog.sfgate.com/opinionshop/2011/03/24/nfl-players-suicide-opens-discussion-on-traumatic-brain-injury/.Google Scholar
The Lasker Legacy. Lasker Foundation, 2014. Available at www.laskerfoundation.org/about/legacy.htm.Google Scholar
National Institute of Health. Estimates of funding for various research, condition, and disease categories (RCDC) March 7, 2017. Available at www.report.nih.gov/categorical_spending.aspx.Google Scholar
Zitnay, GA. Lessons from national and international TBI societies and funds like NBIRTT. Acta Neurochir 2005;[Suppl]93: 131133.Google ScholarPubMed
Centers for Disease Control and Prevention. CDC estimates of traumatic brain injury-related disability. Traumatic brain injury in the United States: A report to Congress 2014. Available at www.cdc.gov/NCIPC/pub-res/tbi_congress/04_estimates_goals.htm.Google Scholar
Zaloshnja, E, Miller, T, Langlois, JA, Selassie, AW. Prevalence of long-term disability from traumatic brain injury in the civilian population of the United States, 2005. J Head Trauma Rehab 2008;21:394400.CrossRefGoogle Scholar
The CDC, NIH, DoD, and VA Leadership Panel. Report to Congress on traumatic brain injury in the United States: Understanding the public health problem among current and former military personnel. Centers for Disease Control and Prevention (CDC), the National Institutes of Health (NIH), the Department of Defense (DoD), and the Department of Veterans Affairs (VA). 2013.Google Scholar
Centers for Disease Control and Prevention. Diagnoses of HIV infection in the United States and dependent areas, 2011. HIV surveillance report, volume 23. Available at www.cdc.gov/hiv/library/reports/surveillance/2011/surveillance_Report_vol_23.html.Google Scholar
O’Brien, KK, Solomon, P, Bayoumi, AM. Measuring disability experienced by adults living with HIV: Assessing construct validity of the HIV Disability Questionnaire using confirmatory factor analysis. BMJ Open 2014;4:e005456.Google Scholar
Gillum, LA, Gouveia, C, Dorsey, ER, Pletcher, M, Mathers, CD, McCulloch, CE, Johnston, SC. NIH disease funding levels and burden of disease. PLoS One 2011;6:e16837.CrossRefGoogle ScholarPubMed
Centers for Disease Control and Prevention. Injury prevention and control: Traumatic brain injury. Severe traumatic brain injury. 2014. Available at www.cdc.gov/TraumaticBrainInjury/severe.html.Google Scholar
Raymont, V, Salazar, AM, Krueger, F, Grafman, J. “Studying injured minds”: The Vietnam head injury study and 40 years of brain injury research. Front Neurol 2011;2:113.Google Scholar
U.S. Interagency Head Injury Task Force. Interagency head injury task force report. Bethesda, MD: National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, 1989.Google Scholar
Defense Centers of Excellence for Psychological Health and Traumatic Brain Injury (DCoE). Defense and Veterans Brain Injury Center, 2012. Available at www.dcoe.mil/content/Navigation/Documents/About%20DVBIC.pdf.Google Scholar
Public Law 104–166. 104th Congress. An act to amend the Public Health Service Act to provide for the conduct of expanded studies and the establishment of innovative programs with respect to traumatic brain injury, and for other purposes. Available at www.gpo.gov/fdsys/pkg/PLAW-104publ166/html/PLAW-104publ166.htm.Google Scholar
Centers for Disease Control and Prevention, National Center for Injury Prevention and Control. Traumatic brain injury in the United States: A report to Congress. Atlanta, GA: Division of Acute Care, Rehabilitation Research, and Disability Prevention; National Center for Injury Prevention and Control; Centers for Disease Control and Prevention, 1999.Google Scholar
Public Law 106–310. 106th Congress. An act to amend the Public Health Service Act with respect to children’s health. Available at www.gpo.gov/fdsys/pkg/PLAW-106publ310/content-detail.html.Google Scholar
Grinnon, T, Grinnon, ST, Miller, K, Marler, JR, Lu, Y, Stout, A, Odenkirchen, J et al. NINDS Common Data Element project – approach and methods. Clin Trials 2012;9:322329.CrossRefGoogle ScholarPubMed
National Institute of Neurological Disorders and Stroke (NINDS). Mission statement. Available at http://nindscommondataelements.wordpress.com/mission-statement/.Google Scholar
National Center for Injury Prevention and Control. Report to Congress on mild traumatic brain injury in the United States: Steps to prevent a serious public health problem. Atlanta, GA: Centers for Disease Control and Prevention, 2003.Google Scholar
International Mission on Prognosis Analysis of Clinical Trials in Traumatic Brain Injury (IMPACT) 2014. Available at www.tbi-impact.org/?p=home/news.Google Scholar
Maas, AIR, Menon, DK. Traumatic brain injury: Rethinking ideas and approaches. Lancet Neurol 2012;11:1213.Google Scholar
Knuth, T, Letarte, PB, Ling, G, Moores, LE, Rhee, P, Tauber, D, Trask, A. Guidelines for field management of combat-related head trauma. New York: Brain Trauma Foundation, 2005.Google Scholar
Defense Centers of Excellence for Psychological Health and Traumatic Brain Injury (DCoE). 2014. Available at www.dcoe.mil/.Google Scholar
Public Law 110–206 110th Congress. An Act to provide for the expansion and improvement of traumatic brain injury programs.Google Scholar
Management of Concussion/mTBI Working Group. VA/DoD clinical practice guideline for management of concussion/mild traumatic brain injury. J Rehabil Res Dev 2009;46: CP168.CrossRefGoogle Scholar
Carlson, K, Kehle, S, Meis, L, Greer, N, MacDonald, R, Rutks, I. The assessment and treatment of individuals with history of traumatic brain injury and post-traumatic stress disorder: A systematic review of the evidence, 2009. Available at www.hsrd.research.va.gov/publications/esp/tbiptsd.cfm.Google Scholar
Underwood, E. NFL kicks off brain-injury research effort. Science 2013;339:1367.Google Scholar
Wamsley, L. NFL, NIH end partnership for concussion research with $16m unspent. National Public Radio July 29th, 2017. Available at: www.npr.org/sections/thetwo-way/2017/07/29/540238260/nfl-ends-partnership-with-nih-for-concussion-research-with-16m-unspent.Google Scholar
Peliserro, T. NFL says it will commit $100 million in concussion initiative. USA Today September 14, 2016. Available at: www.usatoday.com/story/sports/nfl/2016/09/14/nfl-player-safety-concussions/90346224/.Google Scholar
Jones, M. NFL commits another $16.43 million for concussion research. USA Today. January 5, 2018. Available at: www.usatoday.com/story/sports/nfl/2018/01/05/nfl-commits-another-16-43-million-concussion-research/1007405001/.Google Scholar
Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Working Group Report to the Advisory Committee to the Director, NIH. Brain 2025: A scientific vision. June 5, 2014. Available at www.braininitiative.nih.gov/pdf/BRAIN2025_508C.pdf.Google Scholar
Fernagut, PO, Chesselet, MF. Alpha-synuclein and transgenic mouse models. Neurobiol Dis 2004;17:123130.Google Scholar
Götz, J, Deters, N, Doldissen, A, Bokhari, L, Ke, Y, Wiesner, A, et al. A decade of tau transgenic animal models and beyond. Brain Pathol 2007;17:91103.Google Scholar
Brion, JP, Ando, K, Heraud, C, Leroy, K. Modulation of tau pathology in tau transgenic models. Biochem Soc Trans 2010;38: 9961000.Google Scholar
Crews, L, Rockenstein, E, Masliah, E. APP transgenic modeling of Alzheimer’s disease: Mechanisms of neurodegeneration and aberrant neurogenesis. Brain Struct Funct 2010;214:111126.Google Scholar
Magen, I, Chesselet, MF. Mouse models of cognitive deficits due to alpha-synuclein pathology. J Parkinsons Dis 2011;1:217227.Google Scholar
Lalonde, R, Fukuchi, K, Strazielle, C. APP transgenic mice for modelling behavioural and psychological symptoms of dementia (BPSD). Neurosci Biobehav Rev 2012;36:13571375.Google Scholar
Lalonde, R, Fukuchi, K, Strazielle, C. Neurologic and motor dysfunctions in APP transgenic mice. Rev Neurosci 2012;23:363379.Google Scholar
Youmans, KL, Tai, LM, Nwabuisi-Heath, E, Jungbauer, L, Kanekiyo, T, Gan, M, et al. Model of Alzheimer disease: APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease. Accumulation in a new transgenic mouse APOE4-specific changes in Ab. J Biol Chem 2012;287:4177441786.Google Scholar
Nakagawa, Y, Nakamura, M, McIntosh, TK, Rodriguez, A, Berlin, JA, Smith, DH, et al. Traumatic brain injury in young, amyloid-beta peptide overexpressing transgenic mice induces marked ipsilateral hippocampal atrophy and diminished Abeta deposition during aging. J Comp Neurol 1999;411:390398.Google Scholar
Tran, HT, Sanchez, L, Brody, DL. Inhibition of JNK by a peptide inhibitor reduces traumatic brain injury-induced tauopathy in transgenic mice. J Neuropathol Exp Neurol 2012;71:116129.Google Scholar
Tajiri, N, Kellogg, SL, Shimizu, T, Arendash, GW, Borlongan, CV. Traumatic brain injury precipitates cognitive impairment and extracellular Aβ aggregation in Alzheimer’s disease transgenic mice. PLoS One 2013;8:e78851.Google Scholar
Pineda, JA, Lewis, SB, Valadka, AB, Papa, L, Hannay, HJ, Heaton, SC, et al. Clinical significance of αII-Spectrin breakdown products in cerebrospinal fluid after severe traumatic brain injury. J Neurotrauma 2007;24:354366.Google Scholar
Manley, GT, Diaz-Arrastia, R, Brophy, M, Engel, D, Goodman, C, Gwinn, K, et al. Common data elements for traumatic brain injury: Recommendations from the Biospecimens and Biomarkers Working Group. Arch Phys Med Rehabil 2010;91: 16671672.Google Scholar
Kobeissy, FH, Guingab-Cagmat, JD, Razafsha, M, O’Steen, L, Zhang, Z, Hayes, RL et al. Leveraging biomarker platforms and systems biology for rehabilomics and biologics effectiveness research. PM&R 2011;3:S139S147.Google ScholarPubMed
Berger, RP, Beers, SR, Papa, L, Bell, M. Common data elements for pediatric traumatic brain injury: Recommendations from the biospecimens and biomarkers workgroup. J Neurotrauma 2010;29:672677.Google Scholar
Crawford, F, Crynen, G, Reed, J, Mouzon, B, Bishop, A, Katz, B, et al. Identification of plasma biomarkers of tbi outcome using proteomic approaches in an APOE mouse model. J Neurotrauma 2012;29:246260.Google Scholar
Zurek, J, Fedora, M. The usefulness of S100B, NSE, GFAP, NF-H, secretagogin and Hsp70 as a predictive biomarker of outcome in children with traumatic brain injury. Acta Neurochir 2012;154:93103.Google Scholar
Guingab-Cagmat, JD, Cagmat, EB, Hayes, EB, Anagli, J. Integration of proteomics, bioinformatics, and systems biology in traumatic brain injury biomarker discovery. Front Neurol 2013;12:112.Google Scholar
U.S. Food and Drug Administration. FDA authorizes marketing of first blood test to aid in the evaluation of concussion in adults. July 14, 2018. Available at: www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm596531.htm.Google Scholar
Framingham Heart Study. 2014. Available at www.framinghamheartstudy.org/.Google Scholar
Broglio, SP, McCrea, M, McAllister, T, Harezlak, J, Katz, B, Hack, D, et al. A national study on the effects of concussion in collegiate athletes and US Military Service Academy members: The NCAA–DoD Concussion Assessment, Research and Education (CARE) Consortium structure and methods. Sports Med 2017;47:14371451.CrossRefGoogle Scholar
Track-TBI. Transforming Research and Clinical Knowledge in Traumatic Brain Injury. International Traumatic Brain Injury Research Initiative. Available at https://tracktbi.ucsf.edu/.Google Scholar
Walker, WC, Carne, W, Franke, LM, Nolen, T, Dikmen, SD, Cifu, DX, et al. The Chronic Effects of Neurotrauma Consortium (CENC) multi-centre observational study: Description of study and characteristics of early participants. Brain Injury 2016;30:14691480.CrossRefGoogle ScholarPubMed
Kelman, S. The social nature of the definition problem in health. Int J Health Serv 1975;5:625642.Google Scholar
Merskey, H. Variable meanings for the definition of disease. J Med Philos 1986;11:215232.Google Scholar
Brown, P. Naming and framing: The social construction of diagnosis and illness. J Health Soc Behav 1995;Extra Issue:3452.Google Scholar
Nordby, H. The analytic–synthetic distinction and conceptual analyses of basic health concepts. Med Health Care Philos 2006;9:169180.Google Scholar
Ereshefsky, M. Defining ‘health’ and ‘disease.’ Stud Histor Philos Biol Biomed Sci 2009;40:221227.Google Scholar
Freud, S. The aetiology of hysteria. In The standard edition of the complete psychological works of Sigmund Freud, volume III (1893–1899): Early psycho-analytic publications. London: Hogarth Press, 1962, pp. 187221.Google Scholar
American Psychiatric Association. Diagnostic and statistical manual of mental disorders, fourth edition (DSM-IV). Washington, DC: American Psychiatric Press, 2000, pp. 492, 498.Google Scholar
American Psychiatric Association. Diagnostic and statistical manual of mental disorders, fifth edition (DSM-5). Washington, DC: American Psychiatric Press, 2013.Google Scholar
Cannon, WB. Bodily changes in pain, hunger, fear and rage: An account of recent researches into the function of emotional excitement. New York: D. Appleton, 1915.Google Scholar
Selye, H. Stress in health and disease. Boston: Butterworths, 1976.Google Scholar
von Richthofen, S, Lang, UE, Hellweg, R. Effects of different kinds of acute stress on nerve growth factor content in rat brain. Brain Res 2003;987:207213.Google Scholar
Garcia-Bueno, B, Madrigal, JL, Lizasoain, I, Moro, MA, Lorenzo, P, Leza, JC. The anti-inflammatory prostaglandin 15d-PGJ2 decreases oxidative/nitrosative mediators in brain after acute stress in rats. Psychopharmacol 2005;180:513522.Google Scholar
Shi, SS, Shao, SH, Yuan, BP, Pan, F, Li, ZL. Acute stress and chronic stress change brain-derived neurotrophic factor (BDNF) and tyrosine kinase-coupled receptor (TrkB) expression in both young and aged rat hippocampus. Yonsei Med J 2010;51: 661671.Google Scholar
Sugama, S, Takenouchi, T, Sekiyama, K, Kitani, H, Hashimoto, M. Immunological responses of astroglia in the rat brain under acute stress: Interleukin 1 beta co-localized in astroglia. Neurosci 2011;192:429437.Google Scholar
Chen, L, Lui, S, Wu, QZ, Zhang, W, Zhou, D, Chen, HF, et al. Impact of acute stress on human brain microstructure: An MR diffusion study of earthquake survivors. Hum Brain Map 2013;34:367373.Google Scholar
Norris, JN, Sams, R, Lundblad, P, Frantz, E, Harris, E. Blast-related mild traumatic brain injury in the acute phase: Acute stress reactions partially mediate the relationship between loss of consciousness and symptoms. Brain Inj 2014;28:10521062.Google Scholar
Kutsuna, N, Yamashita, A, Eriguchi, T, Oshima, H, Suma, T, Sakatani, K, et al. Acute stress exposure preceding transient global brain ischemia exacerbates the decrease in cortical remodeling potential in the rat retrosplenial cortex. Neurosci Res 2014;78:6571.Google Scholar
Giza, CC, Hovda, DA. The neurometabolic cascade of concussion. J Athl Training 2001;36:228235.Google Scholar
Shaw, NA. The neurophysiology of concussion. Progr Neurobiol 2002;67:281344.Google Scholar
De Fazio, M, Rammo, R, O’Phelan, K, Ross Bullock, MR. Alterations in cerebral oxidative metabolism following traumatic brain injury. Neurocrit Care 2011;14:9196.Google Scholar
Kiraly, MA, Kiraly, SJ. Traumatic brain injury and delayed sequelae: A review – traumatic brain injury and mild traumatic brain injury (concussion) are precursors to later-onset brain disorders, including early-onset dementia. Sci World J 2007;7:17681776.Google Scholar
Smith, DH, Johnson, VE, Stewart, W. Chronic neuropathologies of single and repetitive TBI: Substrates of dementia? Nat Rev Neurol 2013;9:211221.Google Scholar
Victoroff, J. Traumatic encephalopathy: Review and provisional research diagnostic criteria. NeuroRehabil 2013;32:211224.Google Scholar
Sapolsky, RM. Why stress is bad for your brain. Science 1996;273:749750.Google Scholar
Radley, JJ, Sisti, HM, Hao, J, Rocher, AB, McCall, T, Hof, PR, et al. Chronic behavioral stress induces apical dendritic reorganization in pyramidal neurons of the medial prefrontal cortex. Neurosci 2004;125:16.Google Scholar
Bremner, JD. Stress and brain atrophy. CNS Neurol Disord Drug Targets 2006;5:503512.Google Scholar
Frodl, TS, Koutsouleris, N, Bottlender, R, Born, C, Jäger, M, Scupin, I, et al. Depression-related variation in brain morphology over 3 years: Effects of stress? Arch Gen Psychiatry 2008;65:11561165.Google Scholar
Hedges, DW, Thatcher, GW, Bennett, PJ, Sood, S, Paulson, D, Creem-Regehr, S, et al. Brain integrity and cerebral atrophy in Vietnam combat veterans with and without posttraumatic stress disorder. Neurocase 2007;13:402410.Google Scholar
Lee, KW, Kim, JB, Seo, JS, Kim, TK, Im, JY, Baek, IS, et al. Behavioral stress accelerates plaque pathogenesis in the brain of Tg2576 mice via generation of metabolic oxidative stress. J Neurochem 2009;108:165175.CrossRefGoogle ScholarPubMed
Tavanti, M, Battaglini, M, Borgogni, F, Bossini, L, Calossi, S, Marino, D, et al. Evidence of diffuse damage in frontal and occipital cortex in the brain of patients with post-traumatic stress disorder. Neurol Sci 2012;33:5968.Google Scholar
Cardenas, VA, Samuelson, K, Lenoci, M, Studholme, C, Neylan, TC, Marmar, CR, et al. Changes in brain anatomy during the course of posttraumatic stress disorder. Psychiatry Res 2011;193: 93100.Google Scholar
Shucard, JL, Cox, J, Shucard, DW, Fetter, H, Chung, C, Ramasamy, D, et al. Symptoms of posttraumatic stress disorder and exposure to traumatic stressors are related to brain structural volumes and behavioral measures of affective stimulus processing in police officers. Psychiatry Res 2012;204:2531.Google Scholar
Ohira, H, Matsunaga, M, Isowa, T, Nomura, M, Ichikawa, N, Kimura, K, et al. Polymorphism of the serotonin transporter gene modulates brain and physiological responses to acute stress in Japanese men. Stress 2009;12:533543.Google Scholar
McAllister, TW. Genetic factors modulating outcome after neurotrauma. PM&R 2010;2 (Suppl 2):S241S252.Google Scholar
Weaver, SM, Chau, A, Portelli, JN, Grafman, J. Genetic polymorphisms influence recovery from traumatic brain injury. Neuroscientist 2012;18:631644.Google Scholar
Graham, DP, Helmer, DA, Harding, MJ, Kosten, TR, Petersen, NJ, Nielsen, DA. Serotonin transporter genotype and mild traumatic brain injury independently influence resilience and perception of limitations in veterans. J Psychiatr Res 2013; 4: 835842.CrossRefGoogle Scholar
Smyth, K, Sandhu, SS, Crawford, S, Dewey, D, Parboosingh, J, Barlow, KM. The role of serotonin receptor alleles and environmental stressors in the development of post-concussive symptoms after pediatric mild traumatic brain injury. Dev Med Child Neurol 2014;56:7377.CrossRefGoogle ScholarPubMed
Gould, R, Miller, B, Goldberg, MA, Benson, DF. The validity of hysterical signs and symptoms. J Nerv Mental Dis 1986; 174: 593597.Google Scholar
Black, DN, Seritan, AL, Taber, KH, Hurley, RA. Conversion hysteria: Lessons from functional imaging. J Neuropsychiatr Clin Neurosci 2004;16:245251.Google Scholar
Vuilleumier, P. Hysterical conversion and brain function. In Laureys, S, editor. Progress in Brain Research 2005;150:309329.CrossRefGoogle ScholarPubMed
Aybek, S, Kanaan, RA, David, AS. The neuropsychiatry of conversion disorder. Curr Opin Psychiatry 2008;21:275280.CrossRefGoogle ScholarPubMed
Voon, V, Gallea, C, Hattori, N, Bruno, M, Ekanayake, V, Hallett, M. The involuntary nature of conversion disorder. Neurology 2010;74:223228.Google Scholar
Bryant, RA. The neural circuitry of conversion disorder and its recovery. J Abn Psychol 2012;121:289296.CrossRefGoogle ScholarPubMed
Carson, AJ, Brown, R, David, AS, Duncan, R, Edwards, MJ, Goldstein, LH, et al. On behalf of UK-FNS. Functional (conversion) neurological symptoms: Research since the millennium. J Neurol Neurosurg Psychiatry 2012;83:842850.Google Scholar
Sierra, M, Berrios, GE. Towards a neuropsychiatry of conversive hysteria. Cogn Neuropsychiatry 1999;4:267287.Google Scholar
Charcot, JM. Oeuvres complètes, volume 1. Paris: Bureaux du Progrès Médical, 1872. [In English: Charcot, JM. Lectures on diseases of the nervous system. Sigerson G, trans. London: New Sydenham Society, 1877.]Google Scholar
Lazare, A. Conversion symptoms. NEJM 1981 305:745748.Google Scholar
Goetz, CG. J-M Charcot and simulated neurologic disease. Neurology 2007;69:103109.Google Scholar
Nicholson, TRJ, Stone, J, Kanaan, RAA. Conversion disorder: A problematic diagnosis. Neurol Neurosurg Psychiatry 2011;82:12671273.Google Scholar
Lipman, FD. Malingering in personal injury cases. Temple Law Q 1962;35:141162.Google Scholar
Travin, S, Potter, B. Malingering and malingering-like behavior. Some clinical and conceptual issues. Psychiatr Quart 1984;56:189197.Google Scholar
Rogers, R. Clinical assessment of malingering and deception. New York: Guilford Press, 1988.Google Scholar
Nies, KJ, Sweet, JJ. Neuropsychological assessment and malingering: A critical review of past and present strategies. Arch Clin Neuropsychol 1994;9:501552.Google Scholar
Eisendrath, SJ. Factitious illness: A clarification. Psychosomatics 1984;25:110117.Google Scholar
Eisendrath, SJ. Factitious disorders in civil litigation: Twenty cases illustrating the spectrum of abnormal illness-affirming behavior. J Am Acad Psychiatry Law 2002;30:391399.Google Scholar
Pilowsky, I. A general classification of abnormal illness behaviours. Br J Med Psychol 1978;51:131137.Google Scholar
Trimble, MR. Pseudoseizures. Neurologic Clin 1986;4:53548.Google Scholar
Devinsky, O, Gordon, E. Epileptic seizures progressing into nonepileptic conversion seizures. Neurology 1998;51: 12931296.Google Scholar
Andrade, C, Singh, NM, Bhakta, SG. Simultaneous true seizures and pseudoseizures. J Cin Psychiatry 2006:674:673.Google Scholar
Deibler, MW, Hacker, C, Rough, J, Darby, J, Lamdan, RM. Ganser’s syndrome in a man with AIDS. Psychosomatics 2003;44:342345.Google Scholar
Dwyer, J, Reid, S. Ganser’s syndrome. Lancet 2004;364:471473.Google Scholar
Bowers, KS. On being unconsciously influenced and informed. In Bowers, KS, Meichenbaum, D, editors. The unconscious reconsidered. New York: John Wiley, 1994.Google Scholar
Hilgard, ER. Divided consciousness: Multiple controls in human thought and action. New York: John Wiley, 1986.Google Scholar
Lynn, SJ, Rhue, JW, Weekes, JR. Hypnotic involuntariness: A social cognitive analysis. Psychol Rev 1990; 97: 169184.Google Scholar
Spanos, NP, deGros, M. Structure of communication and reports of involuntariness by hypnotic and nonhypnotic subjects. Percept Motor Skills 1983;57:11791186.Google Scholar
Jonas, JM, Pope, Jr. HG. The dissimulating disorders: A single diagnostic entity? Compr Psychiatr 1985;26:5862.Google Scholar
Kanaan, RAA, Wessely, SC. Factitious disorders in neurology: An analysis of reported cases. Psychosomatics 2010;51:4754.Google Scholar
Friedman, JH. What do neurologists think about conversion disorder? Nat Rev Neurol 2011;7:306307.CrossRefGoogle ScholarPubMed
Carroll, LJ, Cassidy, JD, Peloso, PM, Borg, J, von Holst, H, Holm, L, et al. Prognosis for mild traumatic brain injury: Results of the WHO Collaborating Centre Task Force on mild traumatic brain injury. J Rehabil Med 2004; Suppl. 43:84105.Google Scholar
Bijur, PE, Haslum, M, Golding, J. Cognitive and behavioral sequelae of mild head injury in children. Pediatrics 1990;86:337344.CrossRefGoogle ScholarPubMed
Bijur, PE, Haslum, M, Golding, J. Cognitive outcomes of multiple mild head injuries in children. J Dev Behav Pediatr 1996;17:143148.Google Scholar
Wrightson, P, McGinn, V, Gronwall, D. Mild head injury in preschool children: Evidence that it can be associated with a persisting cognitive defect. J Neurol Neurosurg Psychiatry 1995;59:375380.Google Scholar
Farmer, MY, Singer, HS, Mellits, ED, Hall, D, Charney, E. Neurobehavioral sequelae of minor head injuries in children. Pediatr Neurosci 1987;13:304308.Google Scholar
Ponsford, J, Willmott, C, Rothwell, A, Cameron, P, Ayton, G, Nelms, R, et al. Cognitive and behavioral outcome following mild traumatic head injury in children. J Head Trauma Rehabil 1999;14:360372.Google Scholar
Greenspan, AI, MacKenzie, EJ. Functional outcome after pediatric head injury. Pediatrics 1994;94:425432.Google Scholar
Graves, DE, Cassidy, JD, editors. Results of the International Collaboration on Mild traumatic brain injury Prognosis (ICoMP). Arch Phys Med Rehabil 2014;95(3, Suppl):A1A6, S95S302.Google Scholar
Michaelsen, LK, Watson, WE, Black, RH. A realistic test of individual versus group consensus decision making. J Appl Psychol 1989;74:834839.Google Scholar
Davis, JH, Kameda, T, Parks, C, Stasson, M, Zimmerman, S. Some social mechanics of group decision making: The distribution of opinion, polling sequence, and implications for consensus. J Personal Soc Psychol 1989; 57:10001012.CrossRefGoogle Scholar
National Institutes of Health. Retirement of the National Institutes of Health Consensus Development Program 2014. Available at http://consensus.nih.gov/.Google Scholar
Rennie, D. Consensus statements. NEJM 1981;304:665666.Google Scholar
Sager, KL, Gastil, J. The origins and consequences of consensus decision making: A test of the social consensus model. Southern Commun J 2006;71:124.Google Scholar
Kameda, T. Procedural influence in consensus information: Evaluating group decision making from a social choice perspective. In Witte, EH, Davis, JH, editors. Understanding group behavior: vol. 1: Consensual action by small groups. Hillside, NJ: Lawrence Erlbaum, 1996, pp. 137161.Google Scholar
Jones, J, Hunter, D. Consensus methods for medical and health services research. BMJ 1995;311:376380.Google Scholar
Greer, AL. The two cultures of public health. JAMA 1987;258:27392740.Google Scholar
Aubry, M, Cantu, R, Dvorak, J, Graf-Baumann, T, Johnston, K, Kelly, J, et al. Concussion in Sport Group. Summary and agreement statement of the First International Conference on Concussion in Sport, Vienna 2001. Br J Sports Med 2002;36:610.Google Scholar
McCrory, P, Johnston, K, Meeuwisse, W, Aubry, M, Cantu, R, Dvorak, J, et al. Summary and agreement statement of the 2nd International Conference on Concussion in Sport, Prague 2004. Br J Sports Med 2005;39:196204.Google Scholar
McCrory, P, Meeuwisse, W, Johnston, K, Dvorak, J, Aubry, M, Molloy, M, et al. Consensus statement on concussion in sport – The 3rd International Conference on Concussion in Sport held in Zurich, November 2008. J Clin Neurosci 2009;16:755763.Google Scholar
McCrory, P, Meeuwisse, W, Aubry, M, Cantu, B, Dvorak, J, Echemendia, R, et al. Consensus statement on Concussion in Sport – The 4th International Conference on Concussion in Sport held in Zurich, November 2012. Phys Ther Sport 2013;14:e1e13.Google Scholar
Hinchey, SA, Jackson, JL. A cohort study assessing difficult patient encounters in a walk-in primary care clinic: Predictors and outcomes. J Gen Intern Med 2011;26:588594.Google Scholar
An, PG, Manwell, LB, Williams, ES, Laiteerapong, N, Brown, RL, Rabatin, JS, et al. Does a higher frequency of difficult patient encounters lead to lower quality care? J Fam Pract 2013;62:2429.Google Scholar
Goode, RL. Complications of patient selection: Recognizing the difficult patient. Facial Plast Surg Clin North Am 2013;21:579584.Google Scholar
Fiester, A. The “difficult” patient reconceived: An expanded moral mandate for clinical ethics. Am J Bioeth 2012;12:27.Google Scholar
Ferrando, SJ, Okoli, U. Personality disorders: Understanding and managing the difficult patient in neurology practice. Semin Neurol 2009;29:266271.Google Scholar
Ricke, AK, Lee, MJ, Chambers, JE. The difficult patient: Borderline personality disorder in the obstetrical and gynecological patient. Obstet Gynecol Surv 2012;67:495502.Google Scholar
Weiss, GG. Taming the difficult patient. Med Econ 2002;79:100, 105, 109.Google Scholar
Surowiecki, J. The wisdom of crowds: Why the many are smarter than the few and how collective wisdom shapes business, economies, societies, and nations. London: Little, Brown, 2004.Google Scholar
Mannes, AE, Soll, JB, Larrick, RP. The wisdom of select crowds. J Personal Soc Psychol 2014:107:276299.Google Scholar
Bloom, BS. Taxonomy of educational objectives, Handbook I. The cognitive domain. New York: David McKay, 1956.Google Scholar
Lezak, MD, Howieson, DB, Bigler, ED, Tranel, D. Neuropsychological assessment, 5th edition. Oxford: Oxford University Press, 2012.Google Scholar
Heaton, RK. A manual for the Wisconsin card sorting test. Odessa, FL: Psychological Assessment Resources, 1980.Google Scholar
Benton, AL, Hamsher de, SK, Sivan, AB. Multilingual aplasia examination, 2nd edition. Iowa City, IA: AJA Associates, 1983.Google Scholar
Dikmen, SS, Machamer, J, Winn, HR, Temkin, NR. Neuropyschological outcome at 1 year post head injury. Neuropsychology 1995;9:8090.Google Scholar
Binder, LM, Rohling, ML. Money matters: A meta-analytic review of financial incentives on recovery after closed-head injury. Am J Psychiatry 1996;153:710.Google Scholar
Binder, LM, Rohling, ML, Larrabee, GJ. A review of mild head trauma. Part I: Meta-analytic review of neuropsychological studies. J Clin Exp Neuropsychol 1997;19:421431.Google Scholar
Bigler, ED. Distinguished Neuropsychologist Award Lecture 1999. The lesion(s) in traumatic brain injury: Implications for clinical neuropsychology. Arch Clin Neuropsychol 2001;16:95131.Google Scholar
Bigler, ED. Neurobiology and neuropathology underlie the neuropsychological deficits associated with traumatic brain injury. Arch Clin Neuropsychol 2003;18:595621; discussion 623627.Google Scholar
Lees-Haley, PR, Green, P, Rohling, ML, Fox, DD, Allen, LM 3rd. The lesion(s) in traumatic brain injury: Implications for clinical neuropsychology. Arch Clin Neuropsychol 2003;18:585594.Google Scholar
Rohling, ML, Meyers, JE, Millis, SR. Neuropsychological impairment following traumatic brain injury: A dose–response analysis. Clin Neuropsychol 2003;17:289302.Google Scholar
Rohling, ML, Binder, LM, Demakis, GJ, Larrabee, GJ, Ploetz, DM, Langhinrichsen-Rohling, J. A meta-analysis of neuropsychological outcome after mild traumatic brain injury: Re-analyses and reconsiderations of Binder et al. (1997), Frencham et al. (2005), and Pertab et al. (2009). Clin Neuropsychol 2011;25:608623.Google Scholar
Rohling, ML, Larrabee, GJ, Millis, R. The “Miserable Minority” following mild traumatic brain injury: Who are they and do meta-analyses hide them? Clin Neuropsychol 2012;26:197213.CrossRefGoogle Scholar
Frencham, KAR, Fox, AM, Maybery, MT. Neuropsychological studies of mild traumatic brain injury: A meta-analytic review of research since 1995. J Clin Exper Neuropsychol 2005;27:334351.Google Scholar
Pertab, JL, James, KM, Bigler, ED. Limitations of mild traumatic brain injury meta-analyses. Brain Inj 2009;23:498508.Google Scholar
Ruff, RM. Two decades of advances in understanding of mild traumatic brain injury. J Head Trauma Rehab 2005;20:518.Google Scholar
Ruff, RM. Mild traumatic brain injury and neural recovery: Rethinking the debate. NeuroRehab 2011;28:167180.Google Scholar
Ruff, RM, Jamora, CW. Myths and mild traumatic brain injury. Psychol Injury Law 2009:2: 3442.Google Scholar
Jamora, CW, Young, A, Ruff, RM. Comparison of subjective cognitive complaints with neuropsychological tests in individuals with mild vs more severe traumatic brain injuries. Brain Inj 2012;26: 3647.Google Scholar
Bigler, ED, Farrer, TJ, Pertab, JL, James, K, Petrie, JA, Hedges, DW. Reaffirmed limitations of meta-analytic methods in the study of mild traumatic brain injury: A response to Rohling et al. Clin Neuropsychol 2013;27:176214.Google Scholar
Larrabee, GJ, Binder, LM, Rohling, ML, Ploetz, DM. Meta-analytic methods and the importance of non-TBI factors related to outcome in mild traumatic brain injury: Response to Bigler et al. (2013). Clin Neuropsychol 2013;27:215237.Google Scholar
Chen, JK, Johnston, KM, Petrides, M, Ptito, A. Neural substrates of symptoms of depression following concussion in male athletes with persisting postconcussion symptoms. Arch Gen Psychiatr 2008; 65:8189.Google Scholar
James, W. The principles of psychology (special ed., vol. II). New York: Henry Holt, 1890.Google Scholar
Chen, C-J, Wu, C-H, Liao, Y-P, Hsu, H-L, Tseng, Y-C, Liu, H-L, et al. Working memory in patients with mild traumatic brain injury: Functional MR imaging analysis. Radiology 2012;264:844851.Google Scholar
Johnson, B, Zhang, K, Gay, M, Horovitz, S, Hallett, M, Sebastianelli, W, et al. Alteration of brain default network in subacute phase of injury in concussed individuals: Resting-state fMRI study. NeuroImage 2011; 59:511518.Google Scholar
McMillan, TM, Teasdale, GM, Weir, CJ, Stewart, E. Death after head injury: The 13 year outcome of a case control study. J Neurol Neurosurg Psychiatry 2011;82:931935.Google Scholar
Rey, A. L’examen psychologique dans les cas d’encéphalopathie traumatique. (Les problèmes.) [The psychological examination in cases of traumatic encephalopathy (Problems).] Arch Psychol 1941;28: 215285.Google Scholar
Ha, J-W, Pyun, S-B, Hwang, YM, Sim, H. Lateralization of cognitive functions in aphasia after right brain damage. Yonsei Med J 2012;53:486494.Google Scholar
Jackson, JH. On the localisation of movements in the brain. London: J. & A. Churchill, 1875.Google Scholar
Booth, JR, Wood, L, Lu, D, Houk, JC, Bitan, T. The role of the basal ganglia and cerebellum in language processing. Brain Res 2007;1133:136144.Google Scholar
Mariën, P, Ackermann, H, Adamaszek, M, Barwood, CH, Beaton, A, Desmond, J et al. Consensus paper: Language and the cerebellum: An ongoing enigma. Cerebellum 2014;13:386410.Google Scholar
Crosson, B, Benefield, H, Cato, MA, Sadek, JR, Moore, AB, Wierenga, CE, et al. Left and right basal ganglia and frontal activity during language generation: Contributions to lexical, semantic, and phonological processes. J Int Neuropsychol Soc 2003;9:10611077.Google Scholar
Levin, HS, Eisenberg, HM, editors. Mild head injury. Oxford: Oxford University Press, 1989.Google Scholar
Marshall, LF, Ruff, RM. Neurosurgeon as victim – a candid depiction of neurosurgeon. In Levin, HS, Eisenberg, HM, editors. Mild head injury. Oxford: Oxford University Press, 1989, pp. 276280.Google Scholar
Mickeviciene, D, Schrader, H, Obelieniene, D, et al. A controlled prospective inception cohort study on the post-concussion syndrome outside the medicolegal context. Eur J Neurol 2004;11:411419.Google Scholar
van Kleef, GA, Oveis, C, van der Löwe, I, LuoKogan, A, Goetz, J, Keltner, D. Power, distress, and compassion: Turning a blind eye to the suffering of others. Psychol Sci 2008;19:13151322.Google Scholar
Stellar, JE, Manzo, VM, Kraus, MW, Keltner, D. Class and compassion: Socioeconomic factors predict responses to suffering. Emotion 2012;12:449459.Google Scholar
Fiske, ST. Controlling other people: The impact of power on stereotyping. Am Psychol 1993;48:621628.Google Scholar
Anderson, C, Berdahl, JL. The experience of power: Examining the effects of power on approach and inhibition tendencies. J Personal Soc Psychol 2002;83: 13621377.Google Scholar
De Dreu, CKW, Van Kleef, GA. The influence of power on the information search, impression formation, and demands in negotiation. J Exp Soc Psychol 2004;40:303319.Google Scholar
Galinsky, AD, Magee, JC, Inesi, ME, Gruenfeld, DH. Power and perspectives not taken. Psychol Sci 2006;17:10681074.Google Scholar
Piff, PK, Kraus, MW, Côté, S, Cheng, BH, Keltner, D. Having less, giving more: The influence of social class on prosocial behavior. J Personal Soc Psychol 2010;99:771784.Google Scholar
Wailoo, K. Pain: A political history. Baltimore, MD: Johns Hopkins University Press, 2014.Google Scholar
McAdams, DP, Albaugh, M, Farber, E, Daniels, J, Logan, RL, Olson, B. Family metaphors and moral intuitions: How conservatives and liberals narrate their lives. J Personal Soc Psychol 2008;95:978990.Google Scholar
Graham, J, Haidt, J, Nosek, BA. Liberals and conservatives rely on different sets of moral foundations. J Personal Soc Psychol 2009;96:10291046.Google Scholar
Hirsh, JB, DeYoung, CG, Xu, X, Peterson, JB. Compassionate liberals and polite conservatives: Associations of agreeableness with political ideology and moral values. Personal Soc Psychol Bull 2010;36:655664.Google Scholar
Carman, KG, Pollard, M. 2014. Adults are concerned about sons playing football, especially the more highly educated and Obama 2012 voters. Available at www.rand.org/blog/2014/11/adults-are-concerned-about-sons-playing-football-especially.html.Google Scholar
Public Broadcasting Service. Frontline. League of denial: The NFL’s concussion crisis. October 8 2013. www.pbs.org/wgbh/pages/frontline/league-of-denial/ (2013) and www.pbs.org/wgbh/pages/frontline/league-of-denial/.Google Scholar
Solomon, GS, Kuhnz, A. Relationship between concussion history and neurocognitive test performance in National Football League draft picks. Am J Sports Med 2014;42:934939.Google Scholar
Kay, T, Newman, B, Cavallo, M, Ezrachi, O, Resnick, M. Toward a neuropsychological model of functional disability after mild traumatic brain injury. Neuropsychology 1992;6:371384.Google Scholar
McMahon, PJ, Hricik, A, Yue, JK, Puccio, AM, Inoue, T, Lingsma, HF, et al. Symptomatology and functional outcome in mild traumatic brain injury: Results from the prospective TRACK-TBI study. J Neurotrauma 2014;31:2633.Google Scholar

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