Book contents
- Frontmatter
- Contents
- Preface
- Contributors
- Part I Clinical Syndromes – General
- Part II Clinical Syndromes – Head and Neck
- Part III Clinical Syndromes – Eye
- Part IV Clinical Syndromes – Skin and Lymph Nodes
- Part V Clinical Syndromes – Respiratory Tract
- Part VI Clinical Syndromes – Heart and Blood Vessels
- Part VII Clinical Syndromes – Gastrointestinal Tract, Liver, and Abdomen
- Part VIII Clinical Syndromes – Genitourinary Tract
- Part IX Clinical Syndromes – Musculoskeletal System
- Part X Clinical Syndromes – Neurologic System
- Part XI The Susceptible Host
- Part XII HIV
- Part XIII Nosocomial Infection
- Part XIV Infections Related to Surgery and Trauma
- Part XV Prevention of Infection
- Part XVI Travel and Recreation
- Part XVII Bioterrorism
- Part XVIII Specific Organisms – Bacteria
- Part XIX Specific Organisms – Spirochetes
- Part XX Specific Organisms – Mycoplasma and Chlamydia
- Part XXI Specific Organisms – Rickettsia, Ehrlichia, and Anaplasma
- Part XXII Specific Organisms – Fungi
- Part XXIII Specific Organisms – Viruses
- Part XXIV Specific Organisms – Parasites
- 193 Intestinal Roundworms
- 194 Tissue Nematodes
- 195 Schistosomes and Other Trematodes
- 196 Tapeworms (Cestodes)
- 197 Toxoplasma
- 198 Malaria: Treatment and Prophylaxis
- 199 Human Babesiosis
- 200 Trypanosomiases and Leishmaniases
- 201 Intestinal Protozoa
- 202 Extraintestinal Amebic Infection
- Part XXV Antimicrobial Therapy – General Considerations
- Index
202 - Extraintestinal Amebic Infection
from Part XXIV - Specific Organisms – Parasites
Published online by Cambridge University Press: 05 March 2013
- Frontmatter
- Contents
- Preface
- Contributors
- Part I Clinical Syndromes – General
- Part II Clinical Syndromes – Head and Neck
- Part III Clinical Syndromes – Eye
- Part IV Clinical Syndromes – Skin and Lymph Nodes
- Part V Clinical Syndromes – Respiratory Tract
- Part VI Clinical Syndromes – Heart and Blood Vessels
- Part VII Clinical Syndromes – Gastrointestinal Tract, Liver, and Abdomen
- Part VIII Clinical Syndromes – Genitourinary Tract
- Part IX Clinical Syndromes – Musculoskeletal System
- Part X Clinical Syndromes – Neurologic System
- Part XI The Susceptible Host
- Part XII HIV
- Part XIII Nosocomial Infection
- Part XIV Infections Related to Surgery and Trauma
- Part XV Prevention of Infection
- Part XVI Travel and Recreation
- Part XVII Bioterrorism
- Part XVIII Specific Organisms – Bacteria
- Part XIX Specific Organisms – Spirochetes
- Part XX Specific Organisms – Mycoplasma and Chlamydia
- Part XXI Specific Organisms – Rickettsia, Ehrlichia, and Anaplasma
- Part XXII Specific Organisms – Fungi
- Part XXIII Specific Organisms – Viruses
- Part XXIV Specific Organisms – Parasites
- 193 Intestinal Roundworms
- 194 Tissue Nematodes
- 195 Schistosomes and Other Trematodes
- 196 Tapeworms (Cestodes)
- 197 Toxoplasma
- 198 Malaria: Treatment and Prophylaxis
- 199 Human Babesiosis
- 200 Trypanosomiases and Leishmaniases
- 201 Intestinal Protozoa
- 202 Extraintestinal Amebic Infection
- Part XXV Antimicrobial Therapy – General Considerations
- Index
Summary
Extraintestinal manifestations of invasive amebic disease, although far less common than amebic colitis, are still a significant cause of morbidity and mortality worldwide, accounting for approximately 50 000 deaths annually. The most common presentation, amebic liver abscess, can be diagnosed clinically by its characteristic presentation in conjugation with appropriate epidemiologic risks and supported by several serologic or antigen-based detection tests. Without treatment, amebic liver abscess is almost always fatal, but with prompt and appropriate treatment, the chance of a cure is nearly universal. Other, more rare, manifestations of invasive amebiasis also occur and will be discussed as well. The foundation of successful invasive amebiasis treatment has been metronidazole and the related nitroimidazole, tinidazole, which recently gained U.S. Food and Drug Administration (FDA) approval.
AMEBIC LIVER ABSCESS
In addition to amebic colitis and its complications, extraintestinal manifestations of invasive Entameba histolytica infections can occur, led in frequency by amebic liver abscesses. An estimated 10% of the worldwide 40 to 50 million symptomatic amebic infections will either present as or be complicated by amebic liver abscess. Adult men are 7 to 10 times more likely to have amebic liver abscess than women, but there is no difference between the sexes in children. It has been suggested that the different gender rates in adults may have to do with protective effects of estrogen in women and the role of alcohol in men with hepatocellular damage setting up a nidus for infection during portal drainage from an infected colon.
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- Clinical Infectious Disease , pp. 1405 - 1410Publisher: Cambridge University PressPrint publication year: 2008