This chapter presents definitions, epidemiology and association of epilepsy with toxin-induced seizures. Basic investigations of toxin-induced seizures include standard blood tests, urine toxicology, electrocardiogram, electroencephalogram (EEG), and brain imaging. The immediate treatment of toxin-induced seizures resembles that of any acute seizure and begins with airway, breathing, circulation (ABC). The chapter highlights several toxins of interest either because of their mechanism of action or their importance from a public health point of view. Alcohol (ethanol) is a central nervous system (CNS) depressant. Domoic acid is a toxin that accumulates in marine organisms, particularly those that feed on phytoplankton. Carbon monoxide (CO) is the leading cause of death by poisoning in the United States. Lead poisoning may occur with exposures. Liquid nerve agents, such as sarin (isopropyl methylphosphonofluoridate), are potent and deadly substances used in chemical warfare. Cocaine is an amphetamine narcotic and a common drug of abuse.