Capnography and capnometry provide useful information that may help improve decision-making and reduce complications during transport. This chapter reviews specific clinical applications of capnography and capnometry: assuring proper endotracheal tube placement, monitoring airway circuit integrity, monitoring the consistency of mechanical ventilation, improving safety in procedural sedation, assessing cardiac output, and evaluating patients in cardiac arrest. Capnometry and capnography aid in the confirmation of correct endotracheal tube placement. End-tidal CO2 (ETCO2) measurement can accurately detect esophageal intubation because CO2 is exhaled through the trachea, and not the esophagus. Once an airway device is in place, continuous monitoring is important to assure ventilator circuit patency, including that of the endotracheal tube, and to assure consistent levels of ventilation. Capnography is the gold standard for monitoring patients on airway appliances and ventilator circuits, and there are useful roles for the technology during procedural sedation and evaluating patients in the time surrounding arrest states.