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10.4 - Spectra, Domains and Dimensions of Neurodegenerative Disease

from 10 - Neurodegeneration

Published online by Cambridge University Press:  08 November 2023

By
James B. Rowe  and
Alexander G. Murley
Edited by
Mary-Ellen Lynall ,
Peter B. Jones  and
Stephen M. Stahl
Mary-Ellen Lynall
Affiliation:
University of Cambridge
Peter B. Jones
Affiliation:
University of Cambridge
Stephen M. Stahl
Affiliation:
University of California, San Diego
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Summary

The syndromes caused by Alzheimer’s disease pathology, dementia with Lewy bodies, frontotemporal lobar degeneration and progressive supranuclear palsy pathology are each diverse. For example, Alzheimer’s disease commonly presents with amnesia (and hippocampal atrophy), but it can also present with visuospatial deficits (posterior cortical atrophy), logopenic progressive aphasia (temporoparietal atrophy), corticobasal syndrome (parkinsonism, dystonia, apraxia and higher cognitive deficits) or a behavioural/dysexecutive syndrome [52].

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Cambridge Textbook of Neuroscience for Psychiatrists , pp. 567 - 568
Publisher: Cambridge University Press
Print publication year: 2023

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