Book contents
- Cambridge Textbook Of Neuroscience for Psychiatrists
- Reviews
- Cambridge Textbook of Neuroscience for Psychiatrists
- Copyright page
- Contents
- Contributors
- Introduction
- 1 Cells
- 2 Neurotransmitters and Receptors
- 3 Basic Techniques in Neuroscience
- 4 Neuroanatomy
- 5 Neural Circuits
- 6 Modulators
- 7 Genetics
- 7.1 Basic Genetic Principles and the History of Gene Identification
- 7.2 Common Variation
- 7.3 Rare Variation
- 7.4 Epigenetics
- 7.5 The Clinical Application of Genetics in Psychiatry
- 8 Neurodevelopment and Neuroplasticity
- 9 Integrated Neurobiology of Specific Syndromes and Treatments
- 10 Neurodegeneration
- Index
7.3 - Rare Variation
from 7 - Genetics
Published online by Cambridge University Press: 08 November 2023
- Cambridge Textbook Of Neuroscience for Psychiatrists
- Reviews
- Cambridge Textbook of Neuroscience for Psychiatrists
- Copyright page
- Contents
- Contributors
- Introduction
- 1 Cells
- 2 Neurotransmitters and Receptors
- 3 Basic Techniques in Neuroscience
- 4 Neuroanatomy
- 5 Neural Circuits
- 6 Modulators
- 7 Genetics
- 7.1 Basic Genetic Principles and the History of Gene Identification
- 7.2 Common Variation
- 7.3 Rare Variation
- 7.4 Epigenetics
- 7.5 The Clinical Application of Genetics in Psychiatry
- 8 Neurodevelopment and Neuroplasticity
- 9 Integrated Neurobiology of Specific Syndromes and Treatments
- 10 Neurodegeneration
- Index
Summary
In addition to the contribution from common variation, predisposition to many psychiatric disorders can also be increased by rare variants. A rare variant is one that occurs in the population at a rate of < 1% and rare variants identified to date have much larger effect sizes than individual common SNPs.
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- Information
- Cambridge Textbook of Neuroscience for Psychiatrists , pp. 333 - 335Publisher: Cambridge University PressPrint publication year: 2023