Book contents
- Frontmatter
- Contents
- Contributors
- Part I General Principles of Cell Death
- 1 Human Caspases – Apoptosis and Inflammation Signaling Proteases
- 2 Inhibitor of Apoptosis Proteins
- 3 Death Domain–Containing Receptors – Decisions between Suicide and Fire
- 4 Mitochondria and Cell Death
- 5 The Control of Mitochondrial Apoptosis by the BCL-2 Family
- 6 Endoplasmic Reticulum Stress Response in Cell Death and Cell Survival
- 7 Autophagy – The Liaison between the Lysosomal System and Cell Death
- 8 Cell Death in Response to Genotoxic Stress and DNA Damage
- 9 Ceramide and Lipid Mediators in Apoptosis
- 10 Cytotoxic Granules House Potent Proapoptotic Toxins Critical for Antiviral Responses and Immune Homeostasis
- Part II Cell Death in Tissues and Organs
- Part III Cell Death in Nonmammalian Organisms
- Plate section
6 - Endoplasmic Reticulum Stress Response in Cell Death and Cell Survival
from Part I - General Principles of Cell Death
Published online by Cambridge University Press: 07 September 2011
- Frontmatter
- Contents
- Contributors
- Part I General Principles of Cell Death
- 1 Human Caspases – Apoptosis and Inflammation Signaling Proteases
- 2 Inhibitor of Apoptosis Proteins
- 3 Death Domain–Containing Receptors – Decisions between Suicide and Fire
- 4 Mitochondria and Cell Death
- 5 The Control of Mitochondrial Apoptosis by the BCL-2 Family
- 6 Endoplasmic Reticulum Stress Response in Cell Death and Cell Survival
- 7 Autophagy – The Liaison between the Lysosomal System and Cell Death
- 8 Cell Death in Response to Genotoxic Stress and DNA Damage
- 9 Ceramide and Lipid Mediators in Apoptosis
- 10 Cytotoxic Granules House Potent Proapoptotic Toxins Critical for Antiviral Responses and Immune Homeostasis
- Part II Cell Death in Tissues and Organs
- Part III Cell Death in Nonmammalian Organisms
- Plate section
Summary
Introduction
The endoplasmic reticulum (ER) serves as the primary cellular protein processing factory where polypeptides destined for secretion or membrane insertion are folded. This membrane-bound organelle recruits translating ribosomes, translocates newly synthesized peptides into its lumen, and promotes a variety of post-translational modifications and chaperone-facilitated folding events. Additionally, in higher eukaryotes ER serves as the major intracellular Ca2+ store. Because the ER encompasses about half the total membrane area and one-third the newly translated proteins in a typical eukaryotic cell, its proper function is critical for numerous aspects of cell physiology, including vesicle trafficking, lipid and membrane biogenesis, and protein targeting and secretion. Accordingly, metazoan cells react rapidly to ER dysfunction through a set of adaptive pathways known collectively as the ER stress response (ESR).
- Type
- Chapter
- Information
- ApoptosisPhysiology and Pathology, pp. 51 - 62Publisher: Cambridge University PressPrint publication year: 2011
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