This chapter reviews the four general domains of Complementary and alternative medicine (CAM) therapies for anxiety disorders. Mind-body interventions constitute a major portion of overall CAM use, with about 17% of adults. The CAM domain of biologically based practices for the treatment of anxiety disorders includes a wide range of dietary supplements such as botanicals, animal-derived extracts, vitamins, minerals, fatty acids, amino acids, proteins, and functional foods. Manipulative and body-based practices encompass several heterogeneous CAM interventions and therapies. These include massage therapy, reflexology, acupressure, and other practices. Energy medicine includes putative energies, which have defied measurement by reproducible methods. Clinicians should remain alert for reliable updates as new information becomes available on evidence based treatments. This can be done by searching databases such as Medline, the Cochrane Collaboration, and the National Center for Complementary and Alternative Medicine (NCCAM) website for information on the latest research on each CAM modality.