Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-78c5997874-m6dg7 Total loading time: 0 Render date: 2024-11-05T13:01:42.627Z Has data issue: false hasContentIssue false

Chapter 26 - The Anemia of Aging

from Section 4 - Secondary Anemias

Published online by Cambridge University Press:  18 April 2018

By
Amanda J. Redig  and
Nancy Berliner
Edited by
Edward J. Benz, Jr. ,
Nancy Berliner  and
Fred J. Schiffman
Edward J. Benz, Jr.
Affiliation:
Dana Farber Cancer Institute
Nancy Berliner
Affiliation:
Brigham and Women's Hospital, Boston
Fred J. Schiffman
Affiliation:
Children's Hospital, Boston
Get access

Summary

A summary is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Chapter
Information
Anemia
Pathophysiology, Diagnosis, and Management
 , pp. 185 - 189
Publisher: Cambridge University Press
Print publication year: 2017

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Vanasse, GJ, Berliner, N. Anemia in elderly patients: an emerging problem for the 21st century. Hematology Am Soc Hematol Educ Program. 2010; 2010:271–275. PubMed PMID: 21239805. Epub 2011/01/18.CrossRefGoogle Scholar
Blanc, BFC, Hallberg, L, et al. Nutritional anaemias. Report of a WHO Scientific Group. WHO Tech Rep Ser. 1968; 405:1–40.Google Scholar
Guralnik, JM, Eisenstaedt, RS, Ferrucci, L, Klein, HG, Woodman, RC. Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia. Blood. 2004 Oct 15; 104(8):2263–2268. PubMed PMID: 15238427. Epub 2004/07/09.Google Scholar
US Census 2010.Google Scholar
Moore, KL, Boscardin, WJ, Steinman, MA, Schwartz, JB. Age and sex variation in prevalence of chronic medical conditions in older residents of U.S. nursing homes. J Am Geriatr Soc. 2012 Apr;60(4):756–764. PubMed PMID: 22463062. Epub 2012/04/03.CrossRefGoogle ScholarPubMed
Patel, KV. Epidemiology of anemia in older adults. Semin Hematol. 2008 Oct;45(4):210–217. PubMed PMID: 18809090. Epub 2008/09/24.CrossRefGoogle ScholarPubMed
Paller, CJ, Shiels, MS, Rohrmann, S, Menke, A, Rifai, N, Nelson, WG, et al. Association between sex steroid hormones and hematocrit in a nationally representative sample of men. J Androl. 2012 Nov–Dec;33(6):1332–1341. PubMed PMID: 22604627. Epub 2012/05/19.Google Scholar
Beutler, E, West, C. Hematologic differences between African-Americans and whites: the roles of iron deficiency and alpha-thalassemia on hemoglobin levels and mean corpuscular volume. Blood. 2005 Jul 15; 106(2):740–745. PubMed PMID: 15790781. Epub 2005/03/26.CrossRefGoogle ScholarPubMed
Thomson, CA, Stanaway, JD, Neuhouser, ML, Snetselaar, LG, Stefanick, ML, Arendell, L, et al. Nutrient intake and anemia risk in the women’s health initiative observational study. J Am Diet Assoc. 2011 Apr;111(4):532–541. PubMed PMID: 21443985. Epub 2011/03/30.CrossRefGoogle ScholarPubMed
Patel, KV, Longo, DL, Ershler, WB, Yu, B, Semba, RD, Ferrucci, L, et al. Haemoglobin concentration and the risk of death in older adults: differences by race/ethnicity in the NHANES III follow-up. Br J Haematol. 2009 May;145(4):514–523. PubMed PMID: 19344387. Epub 2009/04/07.CrossRefGoogle Scholar
Semba, RD, Ricks, MO, Ferrucci, L, Xue, QL, Chaves, P, Fried, LP, et al. Types of anemia and mortality among older disabled women living in the community: the Women’s Health and Aging Study I. Aging Clin Exp Res. 2007 Aug;19(4):259–264. PubMed PMID: 17726354. Epub 2007/08/30.Google Scholar
Woodman, R, Ferrucci, L, Guralnik, J. Anemia in older adults. Curr Opin Hematol. 2005 Mar;12(2):123–128. PubMed PMID: 15725902.Google Scholar
Kikuchi, M, Inagaki, T, Shinagawa, N. Five-year survival of older people with anemia: variation with hemoglobin concentration. J Am Geriatr Soc. 2001 Sep;49(9):1226–1228. PubMed PMID: 11559383.Google Scholar
Guralnik, JM, Ershler, WB, Schrier, SL, Picozzi, VJ. Anemia in the elderly: a public health crisis in hematology. Hematology (Am Soc Hematol Educ Program). 2005:528–532. PubMed PMID: 16304431.CrossRefGoogle Scholar
Willems, JM, den Elzen, WP, Vlasveld, LT, Westendorp, RG, Gussekloo, J, de Craen, AJ, et al. No increased mortality risk in older persons with unexplained anaemia. Age Ageing. 2012 Jul;41(4):501–506. PubMed PMID: 22417980. Epub 2012/03/16.CrossRefGoogle ScholarPubMed
Tettamanti, M, Lucca, U, Gandini, F, Recchia, A, Mosconi, P, Apolone, G, et al. Prevalence, incidence and types of mild anemia in the elderly: the “Health and Anemia” population-based study. Haematologica. 2010 Nov;95(11):1849–1856. PubMed PMID: 20534701. PubMed Central PMCID: 2966906. Epub 2010/06/11.Google Scholar
Ferrucci, L, Corsi, A, Lauretani, F, Bandinelli, S, Bartali, B, Taub, DD, et al. The origins of age-related proinflammatory state. Blood. 2005 Mar 15; 105(6):2294–2299. PubMed PMID: 15572589. Epub 2004/12/02.CrossRefGoogle ScholarPubMed
Furst, DE, Kay, J, Wasko, MC, Keystone, E, Kavanaugh, A, Deodhar, A, et al. The effect of golimumab on haemoglobin levels in patients with rheumatoid arthritis, psoriatic arthritis or ankylosing spondylitis. Rheumatology (Oxford). 2013 Jul 9. PubMed PMID: 23838027. Epub 2013/07/11. Eng.Google Scholar
Vanasse, GJ, Jeong, JY, Tate, J, Bathulapalli, H, Anderson, D, Steen, H, et al. A polymorphism in the leptin gene promoter is associated with anemia in patients with HIV disease. Blood. Nov 17; 118(20):5401–5408. PubMed PMID: 21926355. Epub 2011/09/20.CrossRefGoogle Scholar
Hubbard, RE, Sinead O’Mahony, M, Woodhouse, KW. Erythropoietin and anemia in aging and frailty. J Am Geriatr Soc. 2008 Nov;56(11):2164–2165. PubMed PMID: 19016962. Epub 2008/11/20.Google Scholar
Chung, B, Matak, P, McKie, AT, Sharp, P. Leptin increases the expression of the iron regulatory hormone hepcidin in HuH7 human hepatoma cells. J Nutr. 2007 Nov;137(11):2366–2370. PubMed PMID: 17951471. Epub 2007/10/24.CrossRefGoogle ScholarPubMed
Ferrucci, L, Semba, RD, Guralnik, JM, Ershler, WB, Bandinelli, S, Patel, KV, et al. Proinflammatory state, hepcidin, and anemia in older persons. Blood. 2010 May 6; 115(18):3810–3816. PubMed PMID: 20081092. Epub 2010/01/19.Google Scholar
Perlstein, TS, Pande, R, Berliner, N, Vanasse, GJ. Prevalence of 25-hydroxyvitamin D deficiency in subgroups of elderly persons with anemia: association with anemia of inflammation. Blood. Mar 10; 117(10):2800–2806. PubMed PMID: 21239700. Epub 2011/01/18.Google Scholar
Hong, CH, Falvey, C, Harris, TB, Simonsick, EM, Satterfield, S, Ferrucci, L, et al. Anemia and risk of dementia in older adults: Findings from the Health ABC study. Neurology. Aug 6; 81(6):528–533. PubMed PMID: 23902706. Epub 2013/08/02.Google Scholar
Deal, JA, Carlson, MC, Xue, QL, Fried, LP, Chaves, PH. Anemia and 9-year domain-specific cognitive decline in community-dwelling older women: The Women’s Health and Aging Study II. J Am Geriatr Soc. 2009 Sep;57(9):1604–1611. PubMed PMID: 19682133. Epub 2009/08/18.Google Scholar
Yavuz, BB, Cankurtaran, M, Haznedaroglu, IC, Halil, M, Ulger, Z, Altun, B, et al. Iron deficiency can cause cognitive impairment in geriatric patients. J Nutr Health Aging. 2012 Mar;16(3):220–224. PubMed PMID: 22456776. Epub 2012/03/30.CrossRefGoogle ScholarPubMed
Chang, SS, Weiss, CO, Xue, QL, Fried, LP. Patterns of comorbid inflammatory diseases in frail older women: the Women’s Health and Aging Studies I and II. J Gerontol A Biol Sci Med Sci. Apr;65(4):407–413. PubMed PMID: 19933749. Epub 2009/11/26.Google Scholar
Adams, KF Jr., Patterson, JH, Oren, RM, Mehra, MR, O’Connor, CM, Pina, IL, et al. Prospective assessment of the occurrence of anemia in patients with heart failure: results from the Study of Anemia in a Heart Failure Population (STAMINA-HFP) Registry. Am Heart J. 2009 May;157(5):926–932. PubMed PMID: 19376323. Epub 2009/04/21.CrossRefGoogle Scholar
Shah, R, Agarwal, AK. Anemia associated with chronic heart failure: current concepts. Clin Interv Aging. 2013 8:111–122. PubMed PMID: 23403618. Epub 2013/02/14.Google Scholar
Nanas, JN, Matsouka, C, Karageorgopoulos, D, Leonti, A, Tsolakis, E, Drakos, SG, et al. Etiology of anemia in patients with advanced heart failure. J Am Coll Cardiol. 2006 Dec 19; 48(12):2485–2489. PubMed PMID: 17174186. Epub 2006/12/19.CrossRefGoogle ScholarPubMed
Toblli, JE, Lombrana, A, Duarte, P, Di Gennaro, F. Intravenous iron reduces NT-pro-brain natriuretic peptide in anemic patients with chronic heart failure and renal insufficiency. J Am Coll Cardiol. 2007 Oct 23; 50(17):1657–1665. PubMed PMID: 17950147. Epub 2007/10/24.Google Scholar
Anker, SD, Comin, Colet J, Filippatos, G, Willenheimer, R, Dickstein, K, Drexler, H, et al. Ferric carboxymaltose in patients with heart failure and iron deficiency. N Engl J Med. 2009 Dec 17; 361(25):2436–2448. PubMed PMID: 19920054. Epub 2009/11/19.CrossRefGoogle ScholarPubMed
Richardson, CL, Delehanty, LL, Bullock, GC, Rival, CM, Tung, KS, Kimpel, DL, et al. Isocitrate ameliorates anemia by suppressing the erythroid iron restriction response. J Clin Invest. 2013 Aug 1; 123(8):3614–3623. PubMed PMID: 23863711. Epub 2013/07/19.Google Scholar
Den Elzen, WP, Martin-Ruiz, C, von Zglinicki, T, Westendorp, RG, Kirkwood, TB, Gussekloo, J. Telomere length and anaemia in old age: results from the Newcastle 85-plus Study and the Leiden 85-plus Study. Age Ageing. Jul;40(4):494–500. PubMed PMID: 21622673. Epub 2011/05/31.CrossRefGoogle Scholar

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×