A prelude to the American Revolution, the chapter begins with a geological account of migration, spread and settlement of human population in the American continents in the Holocene period. The pre-colonial history of America is the history of efflorescence of several Native American cultures which is evident from archaeological excavations. The first section of the chapter sheds light on the economic, social, and cultural life of the Native Americans along with internal strife and conflicts between the native inhabitants and the Europeans. The discovery of America much before Amerigo Vespucci by the Norse (Vikings) is attested in the next section. The pre-Columbian expeditions were followed by Spanish, Portuguese, French, and later Dutch and English explorations. By explaining the reasons behind colonization in terms of god, glory, and gold, the final section provides detailed accounts of the exploration events and its impact on the indigenous communities and ecosystems of the continents.