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rotamer

Protein Science (1)

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1 results

Rotamer strain as a determinant of protein structural specificity
GREG A. LAZAR, ERIC C. JOHNSON, JOHN R. DESJARLAIS, TRACY M. HANDEL
Journal:

Protein Science / Volume 8 / Issue 12 / December 1999

Published online by Cambridge University Press:

01 December 1999, pp. 2598-2610

Print publication:

December 1999
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We present direct evidence for a change in protein structural specificity due to hydrophobic core packing. High resolution structural analysis of a designed core variant of ubiquitin reveals that the protein is in slow exchange between two conformations. Examination of side-chain rotamers indicates that this dynamic response and the lower stability of the protein are coupled to greater strain and mobility in the core. The results suggest that manipulating the level of side-chain strain may be one way of fine tuning the stability and specificity of proteins.