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We describe the cases of two children who both presented in infancy with recurrent severe pulmonary hypertensive crises. Exhaustive clinical work-up failed to identify an underlying aetiology. The patients had no clinical response to steroids, immunoglobulins, or pulmonary vasodilators. Post-mortem examination revealed extensive invasive pulmonary capillary haemangiomatosis. There was no evidence of pulmonary venous occlusive disease. Given the lethal nature of this condition, early consideration of referral to a lung transplant centre should be considered in selected patients.

Both sublethal and lethal doses of fenitrothion treatment caused positive temperature toxicity relationship in three lepidopteran fifth instar larvae, Achaea Janata, Mythimna separata and Bombyx mori.

The LD50 value was very low at 30°C compared to 28 and 18°C. In all the three species, the insecticide caused greater rate of regurgitation of body fluid at higher temperature. It is believed that the loss of body fluid causes desiccation and enhances the poisoning effects of fenitrothion.

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Infantile pulmonary capillary haemangiomatosis: a lethal form of pulmonary hypertension

Influence of Temperature on Knock-down and Mortality to Fenitrothion in the Three Lepidopteran Species of Insects

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Infantile pulmonary capillary haemangiomatosis: a lethal form of pulmonary hypertension

Influence of Temperature on Knock-down and Mortality to Fenitrothion in the Three Lepidopteran Species of Insects