Crop safety is one of the many considerations when deciding which POST herbicide to use. This research examined relative corn injury as a result of POST herbicides and the effect of including the safener isoxadifen, the choice of a sensitive or tolerant hybrid, or both. The herbicides included commercial combinations of dicamba, diflufenzopyr, nicosulfuron, rimsulfuron, and thifensulfuron, all at twice the labeled rate. Isoxadifen reduced twisting from dicamba plus diflufenzopyr but not with dicamba plus rimsulfuron. Isoxadifen had negligible effect on chlorosis. In general, rimsulfuron plus thifensulfuron caused the most corn stunting, whereas including isoxadifen or using a tolerant hybrid often reduced corn injury. In two of the four years, treatments with rimsulfuron plus thifensulfuron resulted in yield reductions. Although using products with isoxadifen or selecting tolerant hybrids may influence injury, herbicide selection will have the greatest effect on corn injury.