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Case 34 - Lambert–Eaton Myasthenic Syndrome (LEMS)
from Disorders of the Neuromuscular Junction
Jessica E. Hoogendijk, University Medical Center Utrecht, Marianne de Visser, Amsterdam University Medical Center, Pieter A. van Doorn, Erasmus MC, University Medical Center, Rotterdam, Erik H. Niks, Leiden University Medical Center
Book:

Neuromuscular Disease

Print publication:

19 December 2024, pp 165-167
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Summary

A 33-year-old-woman who was diagnosed with chronic fatigue syndrome several years ago noticed a ‘heavy feeling’ and progressive weakness of the upper legs over a period of four months. Climbing stairs became very difficult, and eventually she could no longer walk independently. She did not complain about weakness in her arms. There were no sensory complaints. During the past months, her voice had changed. Especially if she was tired, she would speak ‘like a drunk’. There were no complaints about double vision, drooping eyelids, or swallowing. There were no clear symptoms of autonomic dysfunction. She did not drink alcohol but had smoked at least a pack of cigarettes per day for over 10 years.