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1 results

  • Cochleovestibular nerve involvement in multifocal fibrosclerosis

  • R K Tsuji, A G Bittencourt, M H Arai, E M Santiago Gebrim
  • Journal:
    The Journal of Laryngology & Otology / Volume 126 / Issue 9 / September 2012
    Published online by Cambridge University Press:
    05 July 2012, pp. 935-938
    Print publication:
    September 2012
  • Objectives:

    To report a case of multifocal fibrosclerosis with a nine-year follow up, and to discuss this disease's radiological appearance and management. The disease is a rare systemic disorder of unknown cause characterised by fibrous proliferation involving multiple anatomical sites.

    Case report:

    A 50-year-old woman presented with histological findings characterised by similar inflammatory processes involving the meninges, pituitary gland, peritoneum, retroperitoneum and orbits, prompting a search for a common pathophysiology. A diagnosis of multifocal fibrosclerosis was postulated. Symptom improvement was noted after treatment with prednisone and azathioprine.

    Conclusion:

    This is the first documented case of involvement of the cochleovestibular nerve in a patient with multifocal fibrosclerosis. The rare association between fibrotic diseases and masses showing various clinical patterns should be kept in mind by otolaryngologists, and imaging performed to investigate for multifocal fibrosclerosis. However, diagnosis can only be confirmed with tissue biopsy and histopathological examination.