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2 results

  • Prolactin response to d-fenfluramine in obsessive-compulsive patients, and outcome of fluvoxamine treatment

  • Palmiero Monteleone, Francesco Catapano, Stefania Dl Martino, Ciro Ferraro, Mario Maj
  • Journal:
    The British Journal of Psychiatry / Volume 170 / Issue 6 / June 1997
    Published online by Cambridge University Press:
    03 January 2018, pp. 554-557
    Print publication:
    June 1997
  • Background

    Although several studies have directly explored serotonin (5-HT) transmission in patients with obsessive compulsive disorder (OCD), their results have been inconsistent and their clinical relevance is doubtful

    Method

    According to a double-blind placebo-controlled design, plasma prolactin (PRL) response to a specific serotonergic probe, d-fenfluramine, was measured in 20 drug-free obsessive compulsive patients and in 20 matched healthy controls. After the neuroendocrine test, 5 patients completed a lO-week treatment with fluvoxamine. Psychopathological assessment was performed before and after therapy.

    Results

    PRL response in OCD patients was blunted under the drug-free condition; correlated inversely with pretreatment ratings of obsessive-compulsive and depressive symptomatology; and correlated inversely with the improvement in obsessive-compulsivescore observed after fluvoxamine treatment.

    Conclusions

    These results support the idea of a dysfunction of 5-HT transmission in OCD, and suggest that the greater this impairment, the better the response to drugs which selectively block the reuptake of 5-HT.