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Studies suggest that alcohol consumption and alcohol use disorders have distinct genetic backgrounds.
Methods
We examined whether polygenic risk scores (PRS) for consumption and problem subscales of the Alcohol Use Disorders Identification Test (AUDIT-C, AUDIT-P) in the UK Biobank (UKB; N = 121 630) correlate with alcohol outcomes in four independent samples: an ascertained cohort, the Collaborative Study on the Genetics of Alcoholism (COGA; N = 6850), and population-based cohorts: Avon Longitudinal Study of Parents and Children (ALSPAC; N = 5911), Generation Scotland (GS; N = 17 461), and an independent subset of UKB (N = 245 947). Regression models and survival analyses tested whether the PRS were associated with the alcohol-related outcomes.
Results
In COGA, AUDIT-P PRS was associated with alcohol dependence, AUD symptom count, maximum drinks (R2 = 0.47–0.68%, p = 2.0 × 10−8–1.0 × 10−10), and increased likelihood of onset of alcohol dependence (hazard ratio = 1.15, p = 4.7 × 10−8); AUDIT-C PRS was not an independent predictor of any phenotype. In ALSPAC, the AUDIT-C PRS was associated with alcohol dependence (R2 = 0.96%, p = 4.8 × 10−6). In GS, AUDIT-C PRS was a better predictor of weekly alcohol use (R2 = 0.27%, p = 5.5 × 10−11), while AUDIT-P PRS was more associated with problem drinking (R2 = 0.40%, p = 9.0 × 10−7). Lastly, AUDIT-P PRS was associated with ICD-based alcohol-related disorders in the UKB subset (R2 = 0.18%, p < 2.0 × 10−16).
Conclusions
AUDIT-P PRS was associated with a range of alcohol-related phenotypes across population-based and ascertained cohorts, while AUDIT-C PRS showed less utility in the ascertained cohort. We show that AUDIT-P is genetically correlated with both use and misuse and demonstrate the influence of ascertainment schemes on PRS analyses.
Acute care physicians are frequently faced with diagnosing and treating orthopedic emergencies with limited resources and without immediate specialist availability. Orthopedic Emergencies focuses on the acute management and stabilization of orthopedic injuries with specific recommendations on procedures and the stabilization of fractures and dislocation. The topics are organized anatomically with additional chapters on Procedures, Reduction Techniques, and Immobilization and Splinting. The information needed for a rapid diagnosis is available instantly through the bullet-point-style text, diagrams, images, pearls and pitfalls. There are specific recommendations on which splint to apply and how to position the affected limb, as well as advice on when to arrange follow up with an orthopedist or sports medicine physician. The spiral binding allows the book to lay flat for easy use at the bedside, making Orthopedic Emergencies the ideal companion for all emergency medicine providers including emergency department physicians, sports clinics, family medicine practitioners and mid-level providers.
This chapter presents the key facts, mechanism, anatomy, symptoms, diagnosis, and treatment of pelvic fractures e.g. avulsion fractures, and non-displaced pelvic fractures such as pubic ramis fractures, ischial body fractures, ilium fractures, sacral fractures, coccyx fractures, displaced pelvic fractures, acetabular fractures and hip fractures. Pelvic fractures represent 3% of all fractures, and are associated with significant morbidity and mortality. The mortality rate for high-energy pelvic fractures is between 10% and 20%. The pelvis consists of the ilium and pubis, and the ilium on each side forming the innominate bones that are then joined at the pubis symphysis anteriorly and the sacrum posteriorly. Fractures involving a single pubic ramis are usually caused by a fall in the elderly, though in the young it is often the result of persistent tension/stress on the adductors or hamstrings resulting in a fracture at their site of origination.
This chapter presents the key facts, diagnostic testing, treatments, and prognosis of various types of hand and wrist fractures such as distal radius fracture, distal radioulnar joint disruption (DRUJ), carpal bone fractures, metacarpal bone fractures, phalangeal bone fractures, and distal phalanx fracture. Distal radius and ulnar injuries are often associated with median and ulnar neuropathies. A transverse fracture of the distal radial metaphysis with dorsal displacement and angulation, often caused by a fall on an outstretched hand. The lateral radiograph is the best view for revealing an intra-articular fracture of the radius and any associated carpal displacement in Barton fractures. A posteroanterior (PA) radiograph often shows a comminuted fracture of the distal radius. Barton fractures require emergency orthopedic/hand-specialist consultation for early operative management. Non-displaced Hutchinson fractures can be managed with a short-arm splint and routine orthopedic/hand-specialist follow-up.
Increased dietary Na intake and decreased dietary K intake are associated with higher blood pressure. It is not known whether the dietary Na:K ratio is associated with all-cause mortality or stroke incidence and whether this relationship varies according to race. Between 2003 and 2007, the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort enrolled 30 239 black and white Americans aged 45 years or older. Diet was assessed using the Block 98 FFQ and was available on 21 374 participants. The Na:K ratio was modelled in race- and sex-specific quintiles for all analyses, with the lowest quintile (Q1) as the reference group. Data on other covariates were collected using both an in-home assessment and telephone interviews. We identified 1779 deaths and 363 strokes over a mean of 4·9 years. We used Cox proportional hazards models to obtain multivariable-adjusted hazard ratios (HR). In the highest quintile (Q5), a high Na:K ratio was associated with all-cause mortality (Q5 v. Q1 for whites: HR 1·22; 95 % CI 1·00, 1·47, P for trend = 0·084; for blacks: HR 1·36; 95 % CI 1·04, 1·77, P for trend = 0·028). A high Na:K ratio was not significantly associated with stroke in whites (HR 1·29; 95 % CI 0·88, 1·90) or blacks (HR 1·39; 95 % CI 0·78, 2·48), partly because of the low number of stroke events. In the REGARDS study, a high Na:K ratio was associated with all-cause mortality and there was a suggestive association between the Na:K ratio and stroke. These data support the policies targeted at reduction of Na from the food supply and recommendations to increase K intake.
The seventh annual Teaching and Learning Conference (TLC) was held in Philadelphia, Pennsylvania, from February 5 to 7, 2010, with 224 attendees onsite. The theme for the meeting was “Advancing Excellence in Teaching Political Science.” Using the working-group model, the TLC track format encourages in-depth discussion and debate on research dealing with the scholarship of teaching and learning.