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Effects of Non-Collagenous Matrix Proteins, Fatty Acid Derivatives, Etc. on the Nucleation and Growth of Calcium Phosphate on Hydroxyapatite

Published online by Cambridge University Press:  15 February 2011

A. T.-C. Wong  and
J. T. Czernuszka
A. T.-C. Wong
Affiliation:
Department of Materials, University of Oxford, Oxford, U.K
J. T. Czernuszka
Affiliation:
Department of Materials, University of Oxford, Oxford, U.K
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Abstract

The effects of various non-collagenous bone matrix bio-chemicals on the deposition of calcium phosphate on hydroxyapatite surfaces have been studied. Guanidine-HCI bone extract, guanidine-EDTA bone extract and phosphatidylserine all showed an overall inhibitory effect on calcification. Phosphoserine promoted secondary nucleation but hindered crystal growth. Serum albumin altered the lattice structure of the crystals, thus inducing a significant calcium deficiency. This structural change also resulted in a different fracture behaviour.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 252: Symposium T – Tissue-Inducing Biomaterials , 1991 , 49
Copyright
Copyright © Materials Research Society 1992

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References

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