In the first half of the nineteenth century, many Americans visited phrenological practitioners. Some clients were true believers, who consulted phrenology to choose an occupation, select a marriage partner and raise children. But, as this article demonstrates, many others consumed phrenology as an ‘experiment’, testing its validity as they engaged its practice. Consumers of ‘practical phrenology’ subjected themselves to examinations often to test the phrenologist and his practice against their own knowledge of themselves. They also tested whether phrenology was true, according to their own beliefs about race and gender. While historians have examined phrenology as a theory of the mind, we know less about its ‘users’ and how gender, race and class structured their engagement. Based on extensive archival research with letters and diaries, memoirs and marginalia, as well as phrenological readings, this study reveals how a continuum of belief existed around phrenology, from total advocacy to absolute denunciation, with lots of room for acceptance and rejection in between. Phrenologists’ notebooks and tools of salesmanship also show how an experimental environment emerged where phrenologists themselves embraced a culture of testing. In an era of what Katherine Pandora has described as ‘epistemological contests’, audiences confronted new museums, performances and theatres of natural knowledge and judged their validity. This was also true for phrenology, which benefited from a culture of contested authority. As this article reveals, curiosity, experimentation and even scepticism among users actually helped keep phrenology alive for decades.

The Ospedale Maggiore, known as Ca’ Granda, was founded in 1456 by will of Francesco Sforza, Duke of Milan, and was considered for almost five centuries a model for Milanese, Italian and even European healthcare. Attracting patients from all over Europe, the Ca’ Granda distinguished itself for the introduction of new treatments and innovative health reforms. In the burial ground of the hospital still lie the bodies of the deceased patients, who came from the poorest strata of the population. The study of their remains aims to give back a general identity and a story to each of these persons as well as reconstruct a fraction of the sixteenth century population of Milano as concerns lifestyle and disease and examine practises and therapy of this exceptional hospital. It is estimated that about two million commingled bones and articulated skeletons rest in the crypt, together with other types of findings (e.g., ceramic, coins, clothing). These remains are the object of a large project involving various disciplines ranging from humanities to hard sciences. The aim of this paper is to bring this historical gem to the attention of scholars and provide a glimpse of what its contents have already revealed.

The idea that smallpox could be eradicated was not necessarily the ultimate aim when inoculation was introduced in Europe in the 1720s. This potentiality was not clearly articulated as an aim until the end of the eighteenth century. This article argues that during most of the eighteenth century, the main aim of inoculation was to lead people as safely as possible through what was regarded as an unavoidable disease. Inoculation became safer, simpler and less expensive from the 1760s, but the changing ideas about its potentiality had more complex roots. A new understanding was produced through an interaction between inoculation practice, more general medical theory and developments within probabilistic thinking and political arithmetic. The first part of the article explores how smallpox inoculation was incorporated into existing medical thinking based on traditional humoral pathology. Inoculation was a new technology, but as it was perceived in the early eighteenth century, the innovation did not first and foremost concern the medical principles of the treatment. The second part of the article investigates arguments about why and when to inoculate: what kind of remedy was inoculation for eighteenth-century agents? The article concludes with a discussion on changes emerging towards the end of the century, and relates them to developments during the preceding decades rather than seeing them as inspired precursors of events and ideas to come.