Dr. Crothers puts forward the thesis that in a certain number of cases the development of psychoses and of organic diseases of the nervous system is due to a single profound intoxication by alcohol. In some instances the symptoms of the nervous affection follow immediately on the intoxication; in others a considerable latent period intervenes. Puberty and late middle life are pointed out as times when intoxication is peculiarly liable to be followed by these paralcoholic disorders. The author believes that morbid inebriety appearing late in life has often this origin.