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521 – Serotoninergic Antidepressants and Anticoagulants in Psychogeriatric Wards, Mental Hospital Kromeriz, Czech Republic - What shall we do to Prevent from Serious Drug Interactions?

Published online by Cambridge University Press:  15 April 2020

J. Luzny ,
M. Blazkova ,
F. Honzak ,
V. Bican ,
O. Vyrostkova ,
A. Indrakova  and
I. Pospisilova
J. Luzny
Affiliation:
Mental Hospital Kromeriz, Kromeriz, Czech Republic
M. Blazkova
Affiliation:
Mental Hospital Kromeriz, Kromeriz, Czech Republic
F. Honzak
Affiliation:
Mental Hospital Kromeriz, Kromeriz, Czech Republic
V. Bican
Affiliation:
Mental Hospital Kromeriz, Kromeriz, Czech Republic
O. Vyrostkova
Affiliation:
Mental Hospital Kromeriz, Kromeriz, Czech Republic
A. Indrakova
Affiliation:
Mental Hospital Kromeriz, Kromeriz, Czech Republic
I. Pospisilova
Affiliation:
Mental Hospital Kromeriz, Kromeriz, Czech Republic

Abstract

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Introduction:

Both serotoninergic antidepressants and anticoagulants are widely udes in psychogeriatry. These drugs can develop drug interactions with subsequent risk of bleeding.

Objectives, aims:

To determine risk of potential drug interactions between serotoninergic antidepressants and anticoagulants serotoninergic antidepressants and anticoagulants with subsequent risk of bleeding.

Methods:

Retrospective analysis of medical records and laboratory checks (INR values) in senior patients treated with serotoninergic antidepressants and anticoagulants (Mental hospital Kromeriz, Czech republic, year 2011).

Results:

In 15.5% of patients treated with combination serotoninergic antidepressant / anticoagulant the dosage of anticoagulant had to be decreased due to unwanted elevation of INR value. In 0.6% of patients the risk of bleeding was clinically evident.

Conclusion:

Serotoninergic antidepressants and anticoagulants are common drugs used in treating seniors with mental disorder and potential drug interactions between them should be taken into account.

Type
Abstract
Information
European Psychiatry , Volume 28 , Issue S1: Abstracts of the 21th European Congress of Psychiatry , 2013 , 28-E112
Copyright
Copyright © European Psychiatric Association 2013
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