Vascular factor is very important in the development of AD. The research investigates the changes in the cerebral angioarchitectonics at various AD stages.

The research included 92 patients of which:

Test Group: 47 aged 34–79 suffering from AD different stages including:

• 4 with preclinical stages or high risk of disease development (TDR-0);

• 15 with mild dementia (TDR-1);

• 20 with moderate dementia (TDR-2);

• 8 with severe dementia (TDR-3).

Control Group: 45 aged 28–78 with various types of brain lesions accompanied by dementia but without Alzheimer’s disease including:

• 15 with chronic cerebrovascular insufficiency of atherosclerotic genesis and moderate dementia;

• 12 with severe vascular dementia;

• 14 with atherosclerotic parkinsonism;

• 4 with Parkinson’s disease.

Each patient underwent MRI, CT, SG, REG, MUGA.

At AD different stages, changes in angioarchitectonics and microcirculation show themselves in:

• lack of expressed atherosclerotic lesions of intracranial vessels - 47 (100%) patients,

• reduction of capillary bed in the temporal and frontoparietal regions - 47 (100%),

• development of multiple arteriovenous shunts in the same areas - 47 (100%),

• corresponding early venous shunts - 47 (100%),

• abnormal development of venous trunks receiving blood from arteriovenous shunts - 42 (89.4%),

• venous congestion at frontal and parietal region border - 43 (91.5%),

• increased loop fromation of intracranial arteries - 37 (78.7%).

Control group patients had no combination of such changes.

We named the vascular factor in AD “the discirculatory angiopathy of Alzheimer’s type” (DAAT).