Hostname: page-component-586b7cd67f-dlnhk Total loading time: 0 Render date: 2024-11-29T07:15:22.218Z Has data issue: false hasContentIssue false
  • English
  • Français

The Spectrum of Recurrent Thoughts and Behaviors in Frontotemporal Dementia

Published online by Cambridge University Press:  07 November 2014

Mario F. Mendez  and
Jill S. Shapira
Get access Rights & Permissions [Opens in a new window]

Abstract

This article describes the spectrum of recurrent thoughts and behaviors that can result from frontotemporal dementia (FTD) and its variants. Although repetitive behaviors can result from a range of brain disorders, FTD is the most common neurologic cause of new-onset recurrent thoughts and behaviors in middle or late life. Patients with FTD can manifest typical or bizarre compulsions, hoarding, verbal and motor stereotypies and complex tics; self-injurious acts, perseverations; and fixed, obsessional thoughts. The frequency and variability of these repetitive behaviors suggest a common disturbance of orbitofrontal-basal ganglia circuits involved in response inhibition. The amelioration of these recurrent events with the administration of serotonin selective reuptake inhibitors further suggests a serotonergic deficit.

Type
Case Report
Information
CNS Spectrums , Volume 13 , Issue 3 , March 2008 , pp. 202 - 208
Copyright
Copyright © Cambridge University Press 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1.Neary, D, Snowden, JS, Gustafson, L, et al.Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology. 1998;51:1546–1554.CrossRefGoogle ScholarPubMed
2.Clinical and neuropathological criteria for frontotemporal dementia. The Lund and Manchester Groups. J Neurol Neurosurg Psychiatry. 1994;57:416–418.Google Scholar
3.Mendez, MF, Selwood, A, Mastri, AR, Frey, WH 2nd. Pick's disease versus Alzheimer's disease: a comparison of clinical characteristics. Neurology. 1993;43:289–292.CrossRefGoogle ScholarPubMed
4.Johnson, JK, Diehl, J, Mendez, MF, et al.Frontotemporal lobar degeneration: demographic characteristics of 353 patients. Arch Neurol. 2005;62:925–930.CrossRefGoogle ScholarPubMed
5.Hodges, JR, Davies, RR, Xuereb, JH, et al.Clinicopathological correlates in frontotemporal dementia. Ann Neurol. 2004;56:399–406.CrossRefGoogle ScholarPubMed
6.McKhann, GM. Albert, MS, Grossman, M, et al.Clinical and pathological diagnosis of frontotemporal dementia: report of the Work Group on Frontotemporal Dementia and Pick's Disease. Arch Neurol. 2001;58:1803–1809.CrossRefGoogle Scholar
7.Mott, RT, Dickson, DW, Trojanowski, JQ, et al.Neuropathologic, biochemical, and molecular characterization of the frontotemporal dementias. J Neuropathol Exp Neurol. 2005;64:420–428.CrossRefGoogle ScholarPubMed
8.Pick, A. Über die Beziehungen der senilen Hirnatrophie zur Aphasie. Prag Med Wochenschr. 1892;17:165–167.Google Scholar
9.Kertesz, A, Munoz, DG. Frontotemporal dementia. Med Clin North Am. 2002;86:501–518.CrossRefGoogle ScholarPubMed
10.Forman, MS, Farmer, J, Johnson, JK, et al.Frontotemporal dementia: clinicopathological correlations. Ann Neurol. 2006;59:952–962.CrossRefGoogle ScholarPubMed
11.Josephs, KA, Petersen, RC, Knopman, DS, et al.Clinicopathologic analysis of frontotemporal and corticobasal degenerations and PSP. Neurology. 2006;66:41–48.CrossRefGoogle ScholarPubMed
12.Pasquier, F, Delacourte, A. Non-Alzheimer degenerative dementias. Curr Opin Neurol. 1998;11:417–427.CrossRefGoogle ScholarPubMed
13.Mendez, MF, Cummings, JL. Dementia: A Clinical Approach. 3rd ed. Philadelphia, Penn: Butterworth-Heinemann (Elsevier); 2003.Google Scholar
14.Ratnavalli, E, Brayne, C, Dawson, K, Hodges, JR. The prevalence of frontotemporal dementia. Neurology. 2002:58:1615–1621.CrossRefGoogle ScholarPubMed
15.Duara, R, Barker, W, Luis, CA. Frontotemporal dementia and Alzheimer's disease: differential diagnosis. Dement Geriatr Cogn Disord. 1999;10(suppl 1):37–42.CrossRefGoogle ScholarPubMed
16.Diehl, J, Mayer, T, Kurz, A, Förstl, H. Features of frontotemporal dementia from the perspective of a special family support group [German]. Nervenarzt. 2003;74:445–449.CrossRefGoogle ScholarPubMed
17.Filley, CM, Kleinschmidt-De Masters, BK, Gross, KF. Non-Alzheimer fronto-temporal degenerative dementia. A neurobehavioral and pathologic study. Clin Neuropathol. 1994;13:109–116.Google ScholarPubMed
18.Hooten, WM, Lyketsos, CG. Frontotemporal dementia: a clinicopathological review of four postmortem studies. J Neuropsychiatry Clin Neurosci. 1996;8:10–19.Google ScholarPubMed
19.Miller, BL, Cummings, JL, Villanueva-Meyer, J, et al.Frontal lobe degeneration: clinical, neuropsychological, and SPECT characteristics. Neurology. 1991;41:1374–1382.CrossRefGoogle ScholarPubMed
20.Pasguier, F, Petit, H. Frontotemporal dementia: its rediscovery. Eur Neurol. 1997;38:1–6.CrossRefGoogle Scholar
21.Mendez, MF, Perryman, KM. Neuropsychiatrie features of frontotemporal dementia: evaluation of consensus criteria and review. J Neuropsychiatry Clin Neurosci. 2002;14:424–429.CrossRefGoogle ScholarPubMed
22.Gregory, CA, Hodges, JR. Clinical features of frontal lobe dementia in comparison to Alzheimer's disease. J Neural Transm Suppl. 1996;47:103–123.CrossRefGoogle ScholarPubMed
23.Passant, U, Elfgren, C, Englund, E, Gustafson, L. Psychiatric symptoms and their psychosocial consequences in frontotemporal dementia. Alzheimer Dis Assoc Disord. 2005;19(suppl 1):S15–S18.CrossRefGoogle ScholarPubMed
24.Folstein, MF, Folstein, SE, McHugh, PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189–198.CrossRefGoogle ScholarPubMed
25.Lezak, MD, Howieson, DB, Loring, DW, Hannay, HJ. Neuropsychological Assessment. 3rd ed. New York, NY: Oxford University Press; 2004.Google Scholar
26.Mendez, MRPerryman, KM. Miller, BL, Swartz, JR, Cummings, JL. Compulsive behaviors as presenting symptoms of frontotemporal dementia. J Geriatr Psychiatry Neurol. 1997;10:154–157.CrossRefGoogle ScholarPubMed
27.Tonkonogy, JM, Smith, TW, Barreira, PJ. Obsessive-compulsive disorders in Pick's disease. J Neuropsychiatry Clin Neurosci. 1994;6:176–180.Google ScholarPubMed
28.Miller, BL, Diehl, J, Freedman, M, Kertesz, A. Mendez, M, Rascovsky, K. International approaches to frontotemporal dementia diagnosis: from social cognition to neuropsychology. Ann Neurol. 2003;54(suppl 5):S7–S10.CrossRefGoogle ScholarPubMed
29.Snowden, JS, Neary, D, Mann, DM, Goulding, PJ, Testa, HJ. Progressive language disorder due to lobar atrophy. Ann Neurol. 1992;31:174–183.CrossRefGoogle ScholarPubMed
30.Mendez, MRBagert, BA, Edwards-Lee, T.Self-injurious behavior in frontotemporal dementia. Neurocase. 1997;3:231–236.CrossRefGoogle Scholar
31.Weis, AP, Jenike, MA. Late-onset obsessive-compulsive disorder: a case series. J Neuropsychiatry Clin Neurosci. 2000;12:265–268.CrossRefGoogle Scholar
32.Coetzer, BR. Obsessive-compulsive disorder following brain injury: a review. Int J Psychiatry Med. 2004;34:363–377.CrossRefGoogle ScholarPubMed
33.Berthier, ML, Kulisevsky, JJ, Gironeil, A, Lopez, OL. Obsessive-compulsive disorder and traumatic brain injury: behavioral, cognitive and neuroimaging findings. Neuropsychiatry Neuropsychol Behavl Neurol. 2001;14:23–31.Google ScholarPubMed
34.Berthier, ML, Kulisevsky, J, Gironeil, A, Heras, JA. Obsessive-compulsive disorder associated with brain lesions: clinical phenomenology, cognitive function, and anatomic correlates. Neurology. 1996;47:353–361.CrossRefGoogle ScholarPubMed
35.Childers, MK, Holland, D, Ryan, MG, Rupright, J. Obsessional disorders during recovery from severe head injury: report of four cases. Brain Inj. 1998;12:613–616.CrossRefGoogle ScholarPubMed
36.Carmin, CN, Wiegartz, PS, Yunus, U, Gillock, KLTreatment of late-onset OCD following basal ganglia infarct. Depress Anxiety. 2002;15:87–90.CrossRefGoogle ScholarPubMed
37.Kim, KW, Lee, DY. Obsessive-compulsive disorder associated with a left orbitofrontal infarct. J Neuropsychiatry Clin Neurosci. 2002;14:88–89.CrossRefGoogle ScholarPubMed
38.Mahendran, R. Obsessive compulsive disorder following left middle cerebral artery infarct. Singapore Med J. 2000;41:498–499.Google ScholarPubMed
39.Rodrigo, EP, Adair, JC, Roberts, BB, Graeber, DA. Obsessive-compulsive disorder following bilateral globus pallidus infarction. Biol Psychiatry 1997;42:410–412.Google Scholar
40.John, G, Eapen, V, Shaw, GK. Frontal glioma presenting as anxiety and obsessions: a case report. Acta Neurologica Scand. 1997;96:194–195.CrossRefGoogle ScholarPubMed
41.Gamazo-Garran, P, Soutullo, CA, Ortuno, F. Obsessive-compulsive disorder secondary to brain dysgerminoma in an adolescent boy: a positron emission tomography case report. J Child Adolesc Psychopharmacol. 2002;12:259–263.CrossRefGoogle Scholar
42.Mordecai, D, Shaw, RJ. Fisher, PG, Mittelstadt, PA, Guterman, T, Donald, SS. Case study: suprasellar germinoma presenting with psychotic obsessive-compulsive symptoms. J Child Adolesc Psychopharmacol. 2000;39:116–119.CrossRefGoogle ScholarPubMed
43.Cheyette, SR, Cummings, JL. Encephalitis lethargica: lessons for contemporary neuropsychiatry. J Neuropsychiatry Clin Neurosci. 1995;7:125–134.Google ScholarPubMed
44.Gustafson, L, Brun, A, Passant, U. Frontal lobe degeneration of non-Alzheimer type. Baillieres Clin Neurol. 1992;1:559–582.Google ScholarPubMed
45.Levy, ML. Miller, BL, Cummings, JL, Fairbanks, LA, Craig, A. Alzheimer disease and frontotemporal dementias. Behavioral distinctions. Arch Neurol. 1996;53:687–690.CrossRefGoogle ScholarPubMed
46.Miller, BL, Chang, L, Mena, I, Boone, K, Lesser, IM. Progressive right frontotemporal degeneration: clinical, neuropsychological and SPECT characteristics. Dementia. 1993;4:204–213.Google ScholarPubMed
47.Miller, BL, Darby, AL, Swartz, JR, Yener, GG, Mena, I. Dietary changes, compulsions and sexual behavior in frontotemporal degeneration. Dementia. 1995;6:195–199.Google ScholarPubMed
48.Ames, D, Cummings, JL, Wirshing, WC, Quinn, B, Mahler, M. Repetitive and compulsive behavior in frontal lobe degenerations. J Neuropsychiatry Clin Neurosci. 1994;6:100–113.Google ScholarPubMed
49.Shinagawa, S, Ikeda, M, Fukuhara, R, Tanabe, H. Initial symptoms in frontotemporal dementia and semantic dementia compared with Alzheimer's disease. Dement Geriatr Cogn Disord. 2006;21:74–80.CrossRefGoogle ScholarPubMed
50.Janssen, JC, Warrington, EK, Morris, HR, et al.Clinical features of frontotemporal dementia due to the intronic tau 10(+16) mutation. Neurology. 2002;58:1161–1168.CrossRefGoogle Scholar
51.Pickering-Brown, SM, Richardson, AM, Snowden, JS, et al.Inherited frontotemporal dementia in nine British families associated with intronic mutations in the tau gene. Brain. 2002;125(pt 4):732–751.CrossRefGoogle ScholarPubMed
52.Shigenobu, K, Ikeda, M, Fukuhara, R, et al.The Stereotypy Rating Inventory for frontotemporal lobar degeneration. Psychiatry Res. 2002;110:175–187.CrossRefGoogle ScholarPubMed
53.Nyatsanza, S, Shetty, T, Gregory, C, Lough, S, Dawson, K, Hodges, JR. A study of stereotypic behaviours in Alzheimer's disease and frontal and temporal variant frontotemporal dementia. J Neurol Neurosurg Psychiatry. 2003;74:1398–1402.CrossRefGoogle ScholarPubMed
54.Mendez, MRShapira, JS, Miller, BL. Stereotypical movements and frontotemporal dementia. Mov Disord. 2005;20:742–745.CrossRefGoogle ScholarPubMed
55.Sarazin, M, Miction, A, Pillon, B, et al.Metabolic correlates of behavioral and affective disturbances in frontal lobe pathologies. J Neurol. 2003;250:827–833.CrossRefGoogle ScholarPubMed
56.Rosen, HJ, Allison, SC, Schauer, GF, Gorno-Tempini, ML, Weiner, MW, Miller, BL. Neuroanatomical correlates of behavioural disorders in dementia. Brain. 2005;128:2612–2625.CrossRefGoogle ScholarPubMed
57.McMurtray, AM, Chen, AK, Shapira, JS, et al.Variations in regional SPECT hypoperfusion and clinical features in frontotemporal dementia. Neurology. 2006;66:517–522.CrossRefGoogle ScholarPubMed
58.Snowden, JS, Bathgate, D, Varma, A, Blackshaw, A, Gibbons, ZC. Neary, D. Distinct behavioural profiles in frontotemporal dementia and semantic dementia. J Neurol Neurosurg Psychiatry. 2001;70:323–332.CrossRefGoogle ScholarPubMed
59.Rosso, SM, Roks, G, Stevens, M, et al.Complex compuisive behaviour in the temporal variant of frontotemporal dementia. J Neurol. 2001;248:965–970.CrossRefGoogle ScholarPubMed
60.Thompson, SA, Patterson, K, Hodges, JR. Left/right asymmetry of atrophy in semantic dementia: behavioral-cognitive implications. Neurology. 2003;61:1196–1203.CrossRefGoogle ScholarPubMed
61.Lo Coco, D, Nacci, P. Frontotemporal dementia presenting with pathological gambling. J Neuropsychiatry Clin Neurosci. 2004;16:117–118.CrossRefGoogle ScholarPubMed
62.Kuelz, AK, Hohagen, F, Voderholzer, U. Neuropsychological performance in obsessive-compulsive disorder: a critical review. Biol Psychol. 2004;65:185–236.CrossRefGoogle ScholarPubMed
63.Greisberg, S, McKay, D. Neuropsychology of obsessive-compulsive disorder: a review and treatment implications. Clin Psychol Rev. 2003;23:95–117.CrossRefGoogle ScholarPubMed
64.Bannon, S, Gonsalvez, CJ, Croft, RJ, Boyce, PM. Response inhibition deficits in obsessive-compulsive disorder. Psychiatry Res. 2002;110:165–174.CrossRefGoogle ScholarPubMed
65.Evans, DW, Lewis, MD, Iobst, E. The role of the orbitofrontal cortex in normally developing compulsive-like behaviors and obsessive-compulsive disorder. Brain Cogn. 2004;55:220–234.CrossRefGoogle ScholarPubMed
66.Chacko, RC, Corbin, MA, Harper, RG. Acquired obsessive-compulsive disorder associated with basal ganglia lesions. J Neuropsychiatry Clin Neurosci. 2000;12:269–272.CrossRefGoogle ScholarPubMed
67.Seeley, WW, Bauer, AM, Miller, BL, et al.The natural history of temporal variant frontotemporal dementia. Neurology. 2005;64:1384–1390.CrossRefGoogle ScholarPubMed