Book contents
- Hormones, Cognition and Dementia
- Hormones, Cognition and Dementia
- Copyright page
- Contents
- Contributors
- Preface
- Section 1 Estrogens and cognition: perspectives and opportunities in the wake of the Women's Health Initiative Memory Study
- Section 2 Varieties of estrogenic therapy
- Section 3 Potential modulators and modifiers of estrogenic effects
- Section 4 Possible genetic factors related to hormone treatment effects
- Section 5 Testosterone, estradiol and men, and sex hormone binding globulin
- Chapter 19 Androgens and cognitive functioning in women
- Chapter 20 The role of estradiol in testosterone treatment
- Chapter 21 Endogenous testosterone levels and cognitive aging in men
- Chapter 22 Clinical trials and neuroimaging studies of testosterone in men: insights into effects on verbal memory
- Chapter 23 Testosterone therapy and Alzheimer's disease: potential for treatment and prevention in women
- Chapter 24 Endogenous estradiol and dementia in elderly men: the roles of vascular risk, sex hormone binding globulin, and aromatase activity
- Chapter 25 Testosterone regulates Alzheimer's disease pathogenesis
- Section 6 Gonadotropin effects
- Index
- Plate Section
Chapter 24 - Endogenous estradiol and dementia in elderly men: the roles of vascular risk, sex hormone binding globulin, and aromatase activity
from Section 5 - Testosterone, estradiol and men, and sex hormone binding globulin
Published online by Cambridge University Press: 06 July 2010
- Hormones, Cognition and Dementia
- Hormones, Cognition and Dementia
- Copyright page
- Contents
- Contributors
- Preface
- Section 1 Estrogens and cognition: perspectives and opportunities in the wake of the Women's Health Initiative Memory Study
- Section 2 Varieties of estrogenic therapy
- Section 3 Potential modulators and modifiers of estrogenic effects
- Section 4 Possible genetic factors related to hormone treatment effects
- Section 5 Testosterone, estradiol and men, and sex hormone binding globulin
- Chapter 19 Androgens and cognitive functioning in women
- Chapter 20 The role of estradiol in testosterone treatment
- Chapter 21 Endogenous testosterone levels and cognitive aging in men
- Chapter 22 Clinical trials and neuroimaging studies of testosterone in men: insights into effects on verbal memory
- Chapter 23 Testosterone therapy and Alzheimer's disease: potential for treatment and prevention in women
- Chapter 24 Endogenous estradiol and dementia in elderly men: the roles of vascular risk, sex hormone binding globulin, and aromatase activity
- Chapter 25 Testosterone regulates Alzheimer's disease pathogenesis
- Section 6 Gonadotropin effects
- Index
- Plate Section
Summary
In elderly men as in elderly women, endogenous estradiol may play an important role in age-related cognitive impairment. To explore the relation between estradiol, cognition, dementia, and cerebral atrophy, Muller and Geerlings performed a systematic literature review. In their review, the authors found that most studies in elderly men do not report significant associations between estradiol levels and cognitive performance, cognitive decline, dementia, or brain atrophy. Some studies, however, do imply that higher estradiol levels are potentially detrimental, although to the extent that a relation may exist, the magnitude of risk is likely small. Given the long preclinical phase of Alzheimer's disease (AD), it is difficult to infer causality, even in longitudinal studies with long follow-up. Muller and Geerling indicated that the relation between estradiol and vascular risk merits further study with respect to AD. In addition, they provide evidence that sex hormone binding globulin (SHBG) levels and aromatase activity are relevant to questions of AD pathogenesis.
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- Information
- Hormones, Cognition and DementiaState of the Art and Emergent Therapeutic Strategies, pp. 228 - 241Publisher: Cambridge University PressPrint publication year: 2009