Book contents
- Frontmatter
- Contents
- Contributors
- Overview: Biology Is the Foundation of Therapy
- PART I BASIC RESEARCH
- PART II CLINICAL RESEARCH
- 23 Introduction to Clinical Research
- 24 Sarcoma
- 25 Neuroblastoma
- 26 Retinoblastoma
- 27 Primary Brain Tumors and Cerebral Metastases
- 28 Head and Neck Cancer Metastasis
- 29 Cutaneous Melanoma: Therapeutic Approaches for Metastatic Disease
- 30 Gastric Cancer Metastasis
- 31 Metastatic Pancreatic Cancer
- 32 Metastasis of Primary Liver Cancer
- 33 Advances in Management of Metastatic Colorectal Cancer
- 34 Lung Cancer Metastasis
- 35 Metastatic Thyroid Cancer: Evaluation and Treatment
- 36 Metastatic Renal Cell Carcinoma
- 37 Bladder Cancer
- 38 Bone Complications of Myeloma and Lymphoma
- 39 Breast Metastasis
- 40 Gynecologic Malignancies
- 41 Prostate Cancer Metastasis: Thoughts on Biology and Therapeutics
- 42 The Biology and Treatment of Metastatic Testicular Cancer
- 43 Applications of Proteomics to Metastasis Diagnosis and Individualized Therapy
- 44 Critical Issues of Research on Circulating and Disseminated Tumor Cells in Cancer Patients
- 45 Lymphatic Mapping and Sentinel Lymph Node Biopsy
- 46 Molecular Imaging and Metastasis
- 47 Preserving Bone Health in Malignancy and Complications of Bone Metastases
- 48 Role of Platelets and Thrombin in Metastasis
- THERAPIES
- 49 Cancer Nanotechnology Offers Great Promise for Cancer Research and Therapy
- 50 Metronomic Chemotherapy for Treatment of Metastatic Disease: From Preclinical Research to Clinical Trials
- 51 Immunotherapy
- 52 Discovery and Development of Drugs Targeting Tumor Invasion and Metastasis
- 53 The Role of Radiotherapy in the Treatment of Metastatic Disease
- 54 Prospects for Clinical Trials of Metastasis Inhibitors
- Index
- References
52 - Discovery and Development of Drugs Targeting Tumor Invasion and Metastasis
from THERAPIES
Published online by Cambridge University Press: 05 June 2012
- Frontmatter
- Contents
- Contributors
- Overview: Biology Is the Foundation of Therapy
- PART I BASIC RESEARCH
- PART II CLINICAL RESEARCH
- 23 Introduction to Clinical Research
- 24 Sarcoma
- 25 Neuroblastoma
- 26 Retinoblastoma
- 27 Primary Brain Tumors and Cerebral Metastases
- 28 Head and Neck Cancer Metastasis
- 29 Cutaneous Melanoma: Therapeutic Approaches for Metastatic Disease
- 30 Gastric Cancer Metastasis
- 31 Metastatic Pancreatic Cancer
- 32 Metastasis of Primary Liver Cancer
- 33 Advances in Management of Metastatic Colorectal Cancer
- 34 Lung Cancer Metastasis
- 35 Metastatic Thyroid Cancer: Evaluation and Treatment
- 36 Metastatic Renal Cell Carcinoma
- 37 Bladder Cancer
- 38 Bone Complications of Myeloma and Lymphoma
- 39 Breast Metastasis
- 40 Gynecologic Malignancies
- 41 Prostate Cancer Metastasis: Thoughts on Biology and Therapeutics
- 42 The Biology and Treatment of Metastatic Testicular Cancer
- 43 Applications of Proteomics to Metastasis Diagnosis and Individualized Therapy
- 44 Critical Issues of Research on Circulating and Disseminated Tumor Cells in Cancer Patients
- 45 Lymphatic Mapping and Sentinel Lymph Node Biopsy
- 46 Molecular Imaging and Metastasis
- 47 Preserving Bone Health in Malignancy and Complications of Bone Metastases
- 48 Role of Platelets and Thrombin in Metastasis
- THERAPIES
- 49 Cancer Nanotechnology Offers Great Promise for Cancer Research and Therapy
- 50 Metronomic Chemotherapy for Treatment of Metastatic Disease: From Preclinical Research to Clinical Trials
- 51 Immunotherapy
- 52 Discovery and Development of Drugs Targeting Tumor Invasion and Metastasis
- 53 The Role of Radiotherapy in the Treatment of Metastatic Disease
- 54 Prospects for Clinical Trials of Metastasis Inhibitors
- Index
- References
Summary
THE ERA OF MOLECULAR TARGETED THERAPY
Efforts to discover and develop novel molecular targeted cancer treatments that commenced in many pharmaceutical companies in the early 1990s have begun to make significant contributions to patient survival. Small-molecule and antibody therapeutics against targets such as EGFR (e.g. cetuximab, erlotinib, gefitinib), erbB2 (trastuzumab, lapatinib), VEGFR (bevacizumab, sorafenib, sunitinib, pazopanib, vandetanib), Abl (imatinib, nilotinib), and mTOR (sirolimus, temsirolimus) have delivered clinical efficacy in certain disease settings. The emergence of these therapies has led to an era of treatments increasingly targeted to selected patient populations, and this has implications for the development of future novel treatments [1–3]. As outcomes improve, increasingly demanding goals are set for new drugs to achieve, both preclinically and in clinical trials.
The majority of small-molecule and antibody agents to date have focused attention on proliferation, survival, and angiogenic pathways. Although there are examples of drugs targeting c-met, TGFβ src, and FAK that have progressed to clinical trials (Table 52.1), there has been relatively little commercial activity specifically targeted against the molecules and pathways contributing to the invasive phenotype and the process of metastasis. Whereas key cell proliferation and survival pathways may ultimately have an impact on metastasis [4–6], it is also clear, from much that has been discussed elsewhere in this volume, that there are targets and pathways not currently exploited, and that disease progression could be modified by modulating the underlying mechanisms contributing to tumor invasion and metastasis.
- Type
- Chapter
- Information
- Cancer MetastasisBiologic Basis and Therapeutics, pp. 600 - 611Publisher: Cambridge University PressPrint publication year: 2011
References
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